CDC73 and GC

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC73	GC
Description		cell division cycle 73	GC vitamin D binding protein
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Extracellular Region Extracellular Space Cytoplasm Cytosol Lysosomal Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	Actin Binding Vitamin D Binding Vitamin Transmembrane Transporter Activity Calcidiol Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Response To Nutrient Levels Vitamin Transmembrane Transport Vitamin D Metabolic Process Vitamin Transport
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Vitamin D (calciferol) metabolism
Drugs			Vitamin D
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Bioavailable vitamin D levels in type 2 diabetes ( 34014961) Granulocyte count ( 27863252) Lymphocyte count ( 32888494) Metabolite levels ( 22916037) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Neutrophil count ( 27863252 32888494) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum 25-Hydroxyvitamin D levels ( 29325163 29545823 31841498 33382404) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum vitamin D-binding protein levels ( 24740207) Serum vitamin D-binding protein levels in type 2 diabetes ( 34014961) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 25208829 22673963 20418485) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764) White blood cell count ( 27863252 32888494)
Interacting Genes		45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1	13 interacting genes: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 HSP90AA1 LRIF1 LRP2 PIK3R3 SERF2
Entrez ID		79577	2638
HPRD ID		09581	00749
Ensembl ID		ENSG00000134371	ENSG00000145321
Uniprot IDs		Q6P1J9	P02774
PDB IDs		5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?		Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal	Mesenchyme Migration Brush Border Membrane Filopodium Extracellular Exosome Skeletal Muscle Thin Filament Assembly Muscle Contraction Cobalamin Transport Muscle System Process Cell Body Apical Part Of Cell Actin Cytoskeleton Circulatory System Process Blood Microparticle Regulation Of Metabolic Process Myosin Binding Apical Plasma Membrane Cargo Receptor Activity Amyloid-beta Clearance Positive Regulation Of Gene Expression Microvillus Membrane Tissue Morphogenesis Response To External Biotic Stimulus Receptor-mediated Endocytosis Regulation Of Macromolecule Metabolic Process Lamellipodium Positive Regulation Of Metabolic Process Lymphocyte Activation Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Vitamin Transport System Process Regulation Of Programmed Cell Death Phosphotyrosine Residue Binding Positive Regulation Of Hepatic Stellate Cell Contraction C5L2 Anaphylatoxin Chemotactic Receptor Binding Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Renal Phosphate Ion Absorption Leukocyte Activation Sarcomere Cardiac Muscle Tissue Morphogenesis Regulation Of Cellular Component Size Brush Border Protein Destabilization Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Hepatic Stellate Cell Migration Response To Other Organism Vascular Process In Circulatory System
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