CDC73 and FAF1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CDC73	FAF1
Gene Name		cell division cycle 73	Fas (TNFRSF6) associated factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cdc73/Paf1 Complex	Nucleus Nuclear Envelope Cytosol CD95 Death-inducing Signaling Complex Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Binding Protein Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Proliferation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)	Depression and alcohol dependence ( 22064162) Ventricular conduction ( 21076409)
Protein-Protein Interactions		30 interactors: ALAS1 ANXA6 CCDC155 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 HAP1 HIST1H1C HSF2BP HSPA4 ITFG1 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 PITHD1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TSGA10 VPS37B WWC1	37 interactors: ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 TAF1D TK1 TNNT1 TSC22D1 UROD VAPB
Entrez ID		79577	11124
HPRD ID		09581	05124
Ensembl ID		ENSG00000134371	ENSG00000185104
Uniprot IDs		Q6P1J9	B4DEJ6 Q9UNN5
PDB IDs			1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2B Ubiquitination Cellular Localization Positive Regulation Of Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Genitalia Morphogenesis Positive Regulation Of Glycoprotein Metabolic Process Organelle Organization Histone Monoubiquitination Regulation Of Glycoprotein Biosynthetic Process Establishment Of Protein Localization To Organelle Protein Localization Chromosome Organization Histone Ubiquitination Protein Import Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Process Cytoplasmic Transport Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Methylation Intracellular Transport Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Organ Growth Organelle Localization Transcription-coupled Nucleotide-excision Repair Regulation Of Oligodendrocyte Differentiation Protein Targeting Protein Monoubiquitination Myoblast Differentiation Regulation Of Intracellular Transport Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Potassium Ion Export Regulation Of Myelination Positive Regulation Of Intracellular Signal Transduction Skin Morphogenesis Vesicle Localization Regulation Of Histone Methylation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Development Genitalia Development Regulation Of Intracellular Signal Transduction Skin Development Regulation Of Epithelial To Mesenchymal Transition Protein Localization To Organelle Protein Transmembrane Transport	Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Cyclic Compound Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Response To Lipid Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Steroid Hormone Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Establishment Of Protein Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Endopeptidase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Peptidase Activity Response To External Stimulus Regulation Of Protein Localization Regulation Of Cellular Localization Leukocyte Homeostasis Regulation Of Immune System Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Kinase Activity Cell Communication Intracellular Receptor Signaling Pathway
Tagcloud ?		1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Difference) ?		1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Intersection) ?