CDC73 and DMPK

Number of citations of the paper that reports this interaction (PubMedID 18687124)
42

Data Source:
BioGRID (two hybrid)

		CDC73	DMPK
Description		cell division cycle 73	DM1 protein kinase
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Nuclear Membrane Mitochondrial Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Sodium Ion Transport Protein Phosphorylation Intracellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Regulation Of Synapse Structural Plasticity
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Ion homeostasis
Drugs			Bisindolylmaleimide VIII
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)	Myotonic dystrophy (DM)
GWAS		Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597)
Interacting Genes		45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1	19 interacting genes: ANXA7 ATN1 ATXN1 CDC73 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4
Entrez ID		79577	1760
HPRD ID		09581	05645
Ensembl ID		ENSG00000134371	ENSG00000104936
Uniprot IDs		Q6P1J9	B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013
PDB IDs		5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	1WT6 2VD5
Enriched GO Terms of Interacting Partners?		Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal	Regulation Of Cardiac Muscle Cell Membrane Potential G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Protein-containing Complex Organization SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Motor Neuron Axon Guidance Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Developmental Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Rhombomere 3 Morphogenesis Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Cis-trans Isomerase Activity Cellular Component Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Protein Glutathionylation Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Insulin-like Growth Factor Receptor Signaling Pathway Spliceosomal SnRNP Assembly Response To Lipid Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Rhombomere 2 Development Positive Regulation Of Transcription By RNA Polymerase II Cytosol Enzyme Inhibitor Activity Focal Adhesion Regulation Of Biological Quality Positive Regulation Of Protein Phosphorylation Visual Behavior Regulation Of The Force Of Heart Contraction By Cardiac Conduction Visual Learning Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade
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