CDC73 and RNF20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDC73	RNF20
Description		cell division cycle 73	ring finger protein 20
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	P53 Binding Chromatin Binding Transcription Coactivator Activity MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Polyubiquitination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Negative Regulation Of Cell Migration Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	E3 ubiquitin ligases ubiquitinate target proteins RHOBTB1 GTPase cycle
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)
Interacting Genes		45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1	41 interacting genes: AIRIM AMOTL2 ATM BAG4 CDC73 DIS3L EEF1D FBH1 FGFR4 H2AC18 H2AC20 H2AC4 H2BC21 H2BC3 H3C14 H4C14 HSF1 HTT ITSN2 KIF11 MSL1 NCBP1 PA2G4 PAF1 PRPF8 RAD51 RB1CC1 RBPMS RPA1 RPA2 SUMO2 TACC3 TRIM14 UBE2A UBE2B UBE2D2 UBE2E1 UBE2L3 USHBP1 XRCC3 ZDHHC17
Entrez ID		79577	56254
HPRD ID		09581	07410
Ensembl ID		ENSG00000134371	ENSG00000155827
Uniprot IDs		Q6P1J9	Q5VTR2
PDB IDs		5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	5TRB 8GUI 8GUJ 8IEJ
Enriched GO Terms of Interacting Partners?		Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal	Structural Constituent Of Chromatin Chromosome, Telomeric Region Nucleus Nucleosome Ubiquitin Conjugating Enzyme Activity Nucleoplasm Chromosome Chromatin Organization Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Protein Heterodimerization Activity Chromatin Remodeling DNA Repair Telomere Maintenance Protein Localization To Chromosome PML Body Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Double-strand Break Repair Chromosome Organization DNA Recombination Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Cellular Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Cycle Process DNA Metabolic Process Protein Polyubiquitination DNA Binding Positive Regulation Of MRNA 3'-end Processing HULC Complex Nuclear Division MRNA 3'-end Processing DNA Damage Response Endodermal Cell Fate Commitment Protein-DNA Complex Assembly Site Of Double-strand Break Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of DNA Metabolic Process Post-translational Protein Modification Meiotic Telomere Clustering
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