CDC73 and RNF20

Number of citations of the paper that reports this interaction (PMID 22021426)
7

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CDC73	RNF20
Gene Name		cell division cycle 73	ring finger protein 20, E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cdc73/Paf1 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex
	Molecular Function	RNA Polymerase II Core Binding Protein Binding	P53 Binding Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Proliferation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cell Migration Positive Regulation Of Histone Methylation Histone H2B Ubiquitination Positive Regulation Of Transcription, DNA-templated
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		30 interactors: ALAS1 ANXA6 CCDC155 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 HAP1 HIST1H1C HSF2BP HSPA4 ITFG1 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 PITHD1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TSGA10 VPS37B WWC1	22 interactors: AMOTL2 ATM CDC73 HIST1H2BB HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HTT ITSN2 MSL1 PA2G4 PAF1 SMURF2 UBC UBE2A UBE2B UBE2E1 USHBP1 WAC ZDHHC17
Entrez ID		79577	56254
HPRD ID		09581	07410
Ensembl ID		ENSG00000134371	ENSG00000155827
Uniprot IDs		Q6P1J9	Q5VTR2
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2B Ubiquitination Cellular Localization Positive Regulation Of Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Genitalia Morphogenesis Positive Regulation Of Glycoprotein Metabolic Process Organelle Organization Histone Monoubiquitination Regulation Of Glycoprotein Biosynthetic Process Establishment Of Protein Localization To Organelle Protein Localization Chromosome Organization Histone Ubiquitination Protein Import Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Process Cytoplasmic Transport Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Methylation Intracellular Transport Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Organ Growth Organelle Localization Transcription-coupled Nucleotide-excision Repair Regulation Of Oligodendrocyte Differentiation Protein Targeting Protein Monoubiquitination Myoblast Differentiation Regulation Of Intracellular Transport Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Potassium Ion Export Regulation Of Myelination Positive Regulation Of Intracellular Signal Transduction Skin Morphogenesis Vesicle Localization Regulation Of Histone Methylation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Development Genitalia Development Regulation Of Intracellular Signal Transduction Skin Development Regulation Of Epithelial To Mesenchymal Transition Protein Localization To Organelle Protein Transmembrane Transport	Histone Ubiquitination Chromatin Organization Histone Modification Histone H2B Ubiquitination Chromosome Organization Protein Monoubiquitination Chromatin Modification Histone Monoubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Cell Cycle Negative Regulation Of Transcription, DNA-templated Organelle Organization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Chromatin Silencing Protein K48-linked Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Cell Cycle Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process G1 DNA Damage Checkpoint Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Methylation On Cytosine Negative Regulation Of Myeloid Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Histone H2A Ubiquitination Positive Regulation Of MRNA 3'-end Processing Chromatin Silencing At RDNA
Tagcloud ?		1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast	abundance coincide contributions di dot1l drives dynamic e3 employ evolutionarily exhibit garnered h2b h2bub1 h3k4me2 h3k79me2 implicate lysines mitosis mitotic normally overlooked patterning ptm reaches requisite rnai stability virtually
Tagcloud (Difference) ?		1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast	abundance coincide contributions di dot1l drives dynamic e3 employ evolutionarily exhibit garnered h2b h2bub1 h3k4me2 h3k79me2 implicate lysines mitosis mitotic normally overlooked patterning ptm reaches requisite rnai stability virtually
Tagcloud (Intersection) ?