CDC73 and RNF40

Number of citations of the paper that reports this interaction (PubMedID 22021426)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CDC73	RNF40
Description		cell division cycle 73	ring finger protein 40
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane HULC Complex
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1	27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DUSP29 EEF1D H2AC4 H2BC3 ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL PKNOX1 RB1 RPA1 RPA2 TRIM51 UBE2A UBE2B UBE2D2 UBE2I UBE2L6 ZCCHC12 ZNF451
Entrez ID		79577	9810
HPRD ID		09581	07411
Ensembl ID		ENSG00000134371	ENSG00000103549
Uniprot IDs		Q6P1J9	A8K6K1 O75150
PDB IDs		5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	8GUI 8GUJ 8IEJ
Enriched GO Terms of Interacting Partners?		Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal	Ubiquitin Conjugating Enzyme Activity Protein Localization To Chromosome PML Body Ubiquitin-like Protein Transferase Activity Chromosome, Telomeric Region Positive Regulation Of MRNA 3'-end Processing HULC Complex Chromatin Organization Nucleus Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Modification By Small Protein Conjugation Protein Polyubiquitination Telomere Localization Regulation Of MRNA 3'-end Processing G-rich Strand Telomeric DNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition DNA Replication Factor A Complex Chromosome Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Site Of Double-strand Break Chromatin Remodeling Telomere Maintenance Proteolysis Involved In Protein Catabolic Process Histone MRNA Metabolic Process Response To Radiation Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Site Of Double-strand Break Sperm Axoneme Assembly Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Mismatch Repair Telomere Organization DNA Repair MRNA 3'-end Processing Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Recombinational Repair Regulation Of DNA Recombination Positive Regulation Of RNA Binding
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