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CEP70 and PLA2G2A
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
CEP70
PLA2G2A
Gene Name
centrosomal protein 70kDa
phospholipase A2, group IIA (platelets, synovial fluid)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Nuclear Membrane
Extracellular Region
Extracellular Space
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Secretory Granule
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Phospholipase A2 Activity
Calcium Ion Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Organelle Organization
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Catabolic Process
Low-density Lipoprotein Particle Remodeling
Somatic Stem Cell Maintenance
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Small Molecule Metabolic Process
Phosphatidic Acid Metabolic Process
Glycerophospholipid Biosynthetic Process
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Pathways
Organelle biogenesis and maintenance
Loss of proteins required for interphase microtubule organization from the centrosome
Loss of Nlp from mitotic centrosomes
G2/M Transition
Assembly of the primary cilium
Centrosome maturation
Regulation of PLK1 Activity at G2/M Transition
Mitotic G2-G2/M phases
Anchoring of the basal body to the plasma membrane
Recruitment of mitotic centrosome proteins and complexes
Cell Cycle, Mitotic
Acyl chain remodelling of PG
Acyl chain remodelling of PE
Synthesis of PA
Metabolism of lipids and lipoproteins
Acyl chain remodelling of PI
Phospholipid metabolism
Glycerophospholipid biosynthesis
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Drugs
Indomethacin
Diclofenac
Ginkgo biloba
1,4-Butanediol
1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
N-Tridecanoic Acid
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid
6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid
Elaidoylamide
1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide
(S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid
Suramin
Diseases
GWAS
Protein-Protein Interactions
134 interactors:
ABT1
AKAP17A
ARHGEF3
ATP5O
ATXN7
BARD1
BEX2
BRMS1
BYSL
C11orf57
C1orf35
C7orf25
C8orf33
CARD9
CCDC85B
CCDC94
CDC73
CDCA7L
CEP57L1
CFAP53
CLPB
COIL
DAZAP2
DDX41
DDX6
DIEXF
DNAJB11
EMD
EMP1
ENKD1
ERCC3
FAM118B
FAM124A
FAM133A
FAM13C
FAM161A
FAM214B
FAM64A
GATAD2B
GCC1
GPATCH2L
GPATCH4
GPX7
HAUS1
HMGB4
HSPD1
IK
IQCE
KANK2
KANSL1
KAT7
KDM1A
KRT31
LAMTOR5
LENG1
LENG8
LIN37
MCM10
MEST
METTL17
MFAP1
MRPL44
NIPSNAP3A
NKAP
NOL12
NOP2
NRIP1
NUSAP1
PAM16
PLA2G2A
PPFIA1
PPIG
PPP1R16B
PRKRIP1
PRPF31
PSMA1
RCOR3
RPL13
SERPINH1
SETD5
SFR1
SH2D4A
SLU7
SMARCE1
SNRPD2
SRGN
SSX3
STK25
STMN2
SUV39H1
SUV39H2
SYT17
SYTL4
SYTL5
TAF1D
TCEB3
TCEB3B
TEAD4
TRIM29
TRIM42
TSGA10IP
TSHZ3
TTC25
TTLL10
TXLNB
UTP11L
UTP14A
ZBTB16
ZBTB24
ZBTB49
ZBTB8A
ZCCHC10
ZFC3H1
ZGPAT
ZNF136
ZNF148
ZNF169
ZNF227
ZNF239
ZNF266
ZNF302
ZNF329
ZNF366
ZNF408
ZNF410
ZNF417
ZNF426
ZNF439
ZNF490
ZNF555
ZNF572
ZNF578
ZNF587
ZSCAN12
24 interactors:
ALOX12
BAG6
CEP70
CRMP1
DCN
JOSD2
PLA2G1B
PLA2R1
SENP6
SENP8
UCHL1
UCHL3
UCHL5
USP15
USP2
USP20
USP28
USP4
USP47
USP5
USP7
USP8
VCAN
VIM
Entrez ID
80321
5320
HPRD ID
16779
01397
Ensembl ID
ENSG00000114107
ENSG00000188257
Uniprot IDs
B7Z2D2
Q8NHQ1
P14555
PDB IDs
1AYP
1BBC
1DB4
1DB5
1DCY
1J1A
1KQU
1KVO
1N28
1N29
1POD
1POE
2GNY
3U8B
3U8D
3U8H
3U8I
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Transcription, DNA-templated
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Cellular Metabolic Process
Cellular Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Ribonucleoprotein Complex Biogenesis
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Biosynthetic Process
RRNA Processing
Regulation Of Cellular Process
RRNA Metabolic Process
Ribosomal Small Subunit Biogenesis
Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Modification
MRNA Metabolic Process
Metabolic Process
Ribosome Biogenesis
Histone H3-K9 Dimethylation
RNA Processing
Chromatin Organization
Histone Modification
Maturation Of SSU-rRNA
Chromosome Organization
Cell Death
Death
Histone H3-K9 Trimethylation
Peptidyl-lysine Dimethylation
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Apoptotic Process
Protein Modification By Small Protein Removal
Protein Deubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Catabolic Process
Proteolysis
Regulation Of Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein K48-linked Deubiquitination
Cellular Metabolic Process
Monoubiquitinated Protein Deubiquitination
Dermatan Sulfate Biosynthetic Process
Regulation Of Phospholipase A2 Activity
Dermatan Sulfate Proteoglycan Biosynthetic Process
Dermatan Sulfate Proteoglycan Metabolic Process
Chondroitin Sulfate Catabolic Process
Protein K63-linked Deubiquitination
Histone Deubiquitination
Chondroitin Sulfate Biosynthetic Process
Metabolic Process
Chondroitin Sulfate Proteoglycan Biosynthetic Process
Regulation Of Protein Stability
Regulation Of Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Leukotriene Metabolic Process
Cellular Process
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Cellular Protein Metabolic Process
Icosanoid Biosynthetic Process
Negative Regulation Of Arachidonic Acid Secretion
Lipoxin B4 Biosynthetic Process
Leukotriene A4 Metabolic Process
Cellular Response To DNA Damage Stimulus
Unsaturated Fatty Acid Biosynthetic Process
Proteoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Chondroitin Sulfate Metabolic Process
Negative Regulation Of Protein Metabolic Process
Tagcloud
?
1p35
adenomas
adenomatous
alleles
borderline
characterised
colonic
disequilibrium
duodenal
fap
genuine
inherited
locus
modifier
modify
mom1
noncoding
p36
phospholipase
pla2s
polymorphic
polyposis
polyps
secretory
silent
sporadic
syntenic
undetected
Tagcloud (Difference)
?
1p35
adenomas
adenomatous
alleles
borderline
characterised
colonic
disequilibrium
duodenal
fap
genuine
inherited
locus
modifier
modify
mom1
noncoding
p36
phospholipase
pla2s
polymorphic
polyposis
polyps
secretory
silent
sporadic
syntenic
undetected
Tagcloud (Intersection)
?