CDC73 and PITHD1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC73	PITHD1
Gene Name		cell division cycle 73	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cdc73/Paf1 Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Proliferation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		30 interactors: ALAS1 ANXA6 CCDC155 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 HAP1 HIST1H1C HSF2BP HSPA4 ITFG1 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 PITHD1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TSGA10 VPS37B WWC1	2 interactors: CDC73 SUMO4
Entrez ID		79577	57095
HPRD ID		09581	13717
Ensembl ID		ENSG00000134371	ENSG00000057757
Uniprot IDs		Q6P1J9	B4DKP7 Q9GZP4
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2B Ubiquitination Cellular Localization Positive Regulation Of Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Genitalia Morphogenesis Positive Regulation Of Glycoprotein Metabolic Process Organelle Organization Histone Monoubiquitination Regulation Of Glycoprotein Biosynthetic Process Establishment Of Protein Localization To Organelle Protein Localization Chromosome Organization Histone Ubiquitination Protein Import Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Process Cytoplasmic Transport Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Methylation Intracellular Transport Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Organ Growth Organelle Localization Transcription-coupled Nucleotide-excision Repair Regulation Of Oligodendrocyte Differentiation Protein Targeting Protein Monoubiquitination Myoblast Differentiation Regulation Of Intracellular Transport Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Potassium Ion Export Regulation Of Myelination Positive Regulation Of Intracellular Signal Transduction Skin Morphogenesis Vesicle Localization Regulation Of Histone Methylation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Development Genitalia Development Regulation Of Intracellular Signal Transduction Skin Development Regulation Of Epithelial To Mesenchymal Transition Protein Localization To Organelle Protein Transmembrane Transport	Histone H2B Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of MRNA 3'-end Processing Endodermal Cell Fate Commitment Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone Monoubiquitination Protein Destabilization Protein Sumoylation Positive Regulation Of DNA-templated Transcription, Elongation MRNA Polyadenylation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Histone Ubiquitination Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation RNA Polyadenylation Endodermal Cell Differentiation Protein Monoubiquitination Regulation Of DNA-templated Transcription, Elongation Endoderm Formation MRNA 3'-end Processing Negative Regulation Of Myeloid Cell Differentiation Endoderm Development Regulation Of MRNA Processing Regulation Of Fibroblast Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast
Tagcloud (Difference) ?		1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast
Tagcloud (Intersection) ?