CEP70 and DNTTIP2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CEP70	DNTTIP2
Name		centrosomal protein 70	deoxynucleotidyltransferase terminal interacting protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton	Nucleus Nucleoplasm Chromosome Nucleolus Small-subunit Processome
	Molecular Function	Protein Binding Identical Protein Binding Gamma-tubulin Binding	RNA Binding Protein Binding
	Biological Process	Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization	RNA Processing Ribosomal Small Subunit Biogenesis
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	None
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Male-pattern baldness ( 28196072 )	Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592 )
Interacting Genes		245 interacting genes: ABT1 AGBL2 AKAP17A ARHGEF3 ARMCX1 ATOSB ATP5PO ATXN7 BARD1 BAZ2B BEX2 BRD1 BRMS1 BRMS1L BRPF1 BYSL C1orf35 C7orf25 C8orf33 CARD9 CAVIN3 CBX8 CCDC187 CCDC85B CDC37 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL CWF19L2 DAXX DAZAP2 DDX41 DDX6 DNAJB11 DNTTIP2 DRC4 DVL3 DYRK1A EAF1 EBNA1BP2 EIF3D ELOA ELOA2 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM161B FAM90A1 GADD45GIP1 GATAD2B GCC1 GEM GLYCTK GPATCH2L GPATCH4 GPX7 GSE1 HAUS1 HDAC4 HDAC6 HIC2 HMGB4 HOXB5 HOXC8 HSPD1 IK INO80B INPP5J IPCEF1 IQCE IQUB ITPKB KANK2 KANSL1 KAT14 KAT5 KAT7 KDM1A KRI1 KRT31 LAMTOR5 LCOR LENG1 LENG8 LIN37 LNX1 MAB21L2 MAGOH MBD3 MCM10 MCRS1 MEST METTL17 MFAP1 MKRN3 MRPL44 NEBL NIPSNAP3A NKAP NKAPD1 NOL12 NOP2 NOP53 NOXA1 NRIP1 NTAQ1 NUSAP1 ODAD4 PAM16 PIBF1 PIMREG PKN1 PLA2G2A PPFIA1 PPIG PPP1R16B PPP1R18 PRKRIP1 PRPF18 PRPF3 PRPF31 PSMA1 PSORS1C2 RASSF10 RBM10 RCOR3 RHPN1 RNF169 RNF6 RPL13 SCNM1 SEC14L1 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SNW1 SOD2 SPANXN3 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TBC1D22B TBC1D30 TCAF1 TCEA2 TCEANC TEAD4 TLK2 TRAF3IP3 TRIM29 TRIM3 TRIM42 TSFM TSGA10IP TSHZ3 TTLL10 TXLNB TXN2 USP2 UTP11 UTP14A UTP14C UTP25 UTP3 VXN WT1 YJU2 ZBTB16 ZBTB24 ZBTB4 ZBTB47 ZBTB48 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZFHX3 ZFP1 ZFP91 ZGPAT ZNF136 ZNF140 ZNF148 ZNF165 ZNF169 ZNF17 ZNF20 ZNF202 ZNF227 ZNF239 ZNF250 ZNF264 ZNF266 ZNF302 ZNF329 ZNF35 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF433 ZNF439 ZNF490 ZNF491 ZNF555 ZNF557 ZNF572 ZNF574 ZNF578 ZNF587 ZNF599 ZNF607 ZNF648 ZNF669 ZNF688 ZNF696 ZNF775 ZNF777 ZNF785 ZNF835 ZNF860 ZSCAN12 ZSCAN21 ZSCAN23	18 interacting genes: CAVIN1 CEP70 DNTT ESR1 ESR2 H2AC25 H2BC1 H3C15 H4C16 PCNA PICK1 PPARG RBPMS RNF10 RNF8 RXRA SPP1 TULP3
Entrez ID		80321	30836
HPRD ID		16779	09994
Ensembl ID		ENSG00000114107	ENSG00000067334
Uniprot IDs		A0A140VJG2 B7Z2D2 Q8NHQ1	Q5QJE6
PDB IDs		Not available	7MQ8 7MQ9 7MQA
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nucleus Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleolus RNA Processing Nuclear Speck Spliceosomal Complex Nucleoplasm RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone Acetyltransferase Complex Chromatin Organization Nuclear Androgen Receptor Binding Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Transcription Elongation By RNA Polymerase II RRNA Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Remodeling Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process RNA Binding DNA-templated Transcription Elongation RNA Metabolic Process Histone H3-K14 Acetyltransferase Complex MRNA Processing Ribonucleoprotein Complex Biogenesis RRNA Metabolic Process Nucleic Acid Metabolic Process	Nuclear Receptor Activity DNA Binding Enzyme Binding Nuclear Steroid Receptor Activity Structural Constituent Of Chromatin Nuclear Receptor-mediated Signaling Pathway Nuclear Estrogen Receptor Activity DNA Binding Domain Binding Nucleosome Nucleosome Organization Transcription Coregulator Binding Positive Regulation Of Lipoprotein Transport Nucleoplasm Chromatin Organization Hormone-mediated Signaling Pathway LBD Domain Binding Identical Protein Binding Chromosome, Telomeric Region Chromatin Remodeling Protein-DNA Complex Assembly Chromatin Regulation Of DNA-templated Transcription Estrogen Response Element Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of RNA Biosynthetic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Intracellular Receptor Signaling Pathway Positive Regulation Of Lipid Transport Chromatin Binding Response To Lipid Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Localization To Chromosome Monocyte Differentiation Sperm DNA Condensation Nucleosome Disassembly Nucleosome Assembly Response To Estradiol Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Disassembly Estrogen Receptor Signaling Pathway Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Androgen Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process