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CEP70 and ARHGEF3
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
CEP70
ARHGEF3
Gene Name
centrosomal protein 70kDa
Rho guanine nucleotide exchange factor (GEF) 3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Nuclear Membrane
Intracellular
Cytosol
Molecular Function
Protein Binding
Rho Guanyl-nucleotide Exchange Factor Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Organelle Organization
Small GTPase Mediated Signal Transduction
Rho Protein Signal Transduction
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Apoptotic Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Organelle biogenesis and maintenance
Loss of proteins required for interphase microtubule organization from the centrosome
Loss of Nlp from mitotic centrosomes
G2/M Transition
Assembly of the primary cilium
Centrosome maturation
Regulation of PLK1 Activity at G2/M Transition
Mitotic G2-G2/M phases
Anchoring of the basal body to the plasma membrane
Recruitment of mitotic centrosome proteins and complexes
Cell Cycle, Mitotic
Rho GTPase cycle
Signaling by GPCR
GPCR downstream signaling
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Rho GTPases
NRAGE signals death through JNK
G alpha (12/13) signalling events
p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Mean platelet volume (
22139419
19110211
19820697
)
Obesity-related traits (
23251661
)
Platelet counts (
22139419
23263863
)
Rheumatoid arthritis (
21452313
)
Protein-Protein Interactions
134 interactors:
ABT1
AKAP17A
ARHGEF3
ATP5O
ATXN7
BARD1
BEX2
BRMS1
BYSL
C11orf57
C1orf35
C7orf25
C8orf33
CARD9
CCDC85B
CCDC94
CDC73
CDCA7L
CEP57L1
CFAP53
CLPB
COIL
DAZAP2
DDX41
DDX6
DIEXF
DNAJB11
EMD
EMP1
ENKD1
ERCC3
FAM118B
FAM124A
FAM133A
FAM13C
FAM161A
FAM214B
FAM64A
GATAD2B
GCC1
GPATCH2L
GPATCH4
GPX7
HAUS1
HMGB4
HSPD1
IK
IQCE
KANK2
KANSL1
KAT7
KDM1A
KRT31
LAMTOR5
LENG1
LENG8
LIN37
MCM10
MEST
METTL17
MFAP1
MRPL44
NIPSNAP3A
NKAP
NOL12
NOP2
NRIP1
NUSAP1
PAM16
PLA2G2A
PPFIA1
PPIG
PPP1R16B
PRKRIP1
PRPF31
PSMA1
RCOR3
RPL13
SERPINH1
SETD5
SFR1
SH2D4A
SLU7
SMARCE1
SNRPD2
SRGN
SSX3
STK25
STMN2
SUV39H1
SUV39H2
SYT17
SYTL4
SYTL5
TAF1D
TCEB3
TCEB3B
TEAD4
TRIM29
TRIM42
TSGA10IP
TSHZ3
TTC25
TTLL10
TXLNB
UTP11L
UTP14A
ZBTB16
ZBTB24
ZBTB49
ZBTB8A
ZCCHC10
ZFC3H1
ZGPAT
ZNF136
ZNF148
ZNF169
ZNF227
ZNF239
ZNF266
ZNF302
ZNF329
ZNF366
ZNF408
ZNF410
ZNF417
ZNF426
ZNF439
ZNF490
ZNF555
ZNF572
ZNF578
ZNF587
ZSCAN12
5 interactors:
CEP70
RHOA
RHOB
TRIM23
TRIM27
Entrez ID
80321
50650
HPRD ID
16779
12480
Ensembl ID
ENSG00000114107
ENSG00000163947
Uniprot IDs
B7Z2D2
Q8NHQ1
E7EU49
E9PG37
Q9NR81
PDB IDs
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Transcription, DNA-templated
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Cellular Metabolic Process
Cellular Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Ribonucleoprotein Complex Biogenesis
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Biosynthetic Process
RRNA Processing
Regulation Of Cellular Process
RRNA Metabolic Process
Ribosomal Small Subunit Biogenesis
Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Modification
MRNA Metabolic Process
Metabolic Process
Ribosome Biogenesis
Histone H3-K9 Dimethylation
RNA Processing
Chromatin Organization
Histone Modification
Maturation Of SSU-rRNA
Chromosome Organization
Cell Death
Death
Histone H3-K9 Trimethylation
Peptidyl-lysine Dimethylation
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Apoptotic Process
Rho Protein Signal Transduction
Small GTPase Mediated Signal Transduction
Cytokinesis
Negative Regulation Of Interleukin-2 Secretion
Skeletal Muscle Satellite Cell Migration
Platelet Activation
Positive Regulation Of Cytoskeleton Organization
Endosomal Transport
Cell Cycle Process
Ras Protein Signal Transduction
Negative Regulation Of Calcium Ion Import
Apolipoprotein A-I-mediated Signaling Pathway
Cleavage Furrow Formation
Transformed Cell Apoptotic Process
Positive Regulation Of Cellular Component Biogenesis
Cell Cycle
Interferon-gamma Secretion
Regulation Of Actin Cytoskeleton Organization
Axon Guidance
Positive Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Blood Coagulation
Cell Division
Hemostasis
Negative Regulation Of Viral Release From Host Cell
Ossification Involved In Bone Maturation
Bone Maturation
Negative Chemotaxis
Mitotic Spindle Assembly
Interferon-gamma Production
Negative Regulation Of Interleukin-2 Production
Regulation Of Cytoskeleton Organization
Intracellular Signal Transduction
Negative Regulation Of Viral Transcription
Regulation Of Viral Release From Host Cell
Positive Regulation Of NF-kappaB Import Into Nucleus
Axonogenesis
Regulation Of Calcium Ion Import
Regulation Of Osteoblast Proliferation
Viral Process
Axon Development
Protein Ubiquitination
Regulation Of Body Fluid Levels
Cell Morphogenesis Involved In Neuron Differentiation
Wound Healing
Chemotaxis
Actin Cytoskeleton Organization
Protein Modification By Small Protein Conjugation
Endosome To Lysosome Transport
Regulation Of Protein Transport
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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