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BAG6 and SMN1
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
HPRD
(two hybrid)
BAG6
SMN1
Description
BAG cochaperone 6
survival of motor neuron 1, telomeric
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Extracellular Exosome
BAT3 Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cajal Body
Nuclear Body
Z Disc
Axon
SMN Complex
SMN-Sm Protein Complex
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Perikaryon
Gemini Of Cajal Bodies
Molecular Function
Signaling Receptor Binding
Protein Binding
Hsp70 Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ribosome Binding
Receptor Ligand Activity
Misfolded Protein Binding
Molecular Adaptor Activity
Proteasome Binding
Protein Carrier Chaperone
Ubiquitin-specific Protease Binding
RNA Binding
Protein Binding
Identical Protein Binding
Biological Process
Kidney Development
Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Chromatin Organization
Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Apoptotic Process
Synaptonemal Complex Assembly
Spermatogenesis
Brain Development
Proteasomal Protein Catabolic Process
Internal Peptidyl-lysine Acetylation
Natural Killer Cell Activation
Cell Differentiation
Lung Development
Regulation Of Protein Stability
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
ERAD Pathway
Maintenance Of Unfolded Protein
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteolysis
Regulation Of Embryonic Development
Protein Stabilization
NK T Cell Activation
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Tail-anchored Membrane Protein Insertion Into ER Membrane
Positive Regulation Of ERAD Pathway
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
Spliceosomal SnRNP Assembly
DNA-templated Transcription Termination
MRNA Processing
Nervous System Development
RNA Splicing
Pathways
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
snRNP Assembly
SARS-CoV-2 modulates host translation machinery
Drugs
Nusinersen
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
A body shape index (
34021172
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Height (
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Schizophrenia (
23894747
)
Small cell lung carcinoma (
28604730
)
Smoking status (ever vs never smokers) (
30643258
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
120 interacting genes:
ACVR1B
AKT1
AMFR
AMTN
ANTKMT
ANXA7
APBB1IP
ARPC3
ATN1
ATXN2
B2M
BCL2
C1QA
CD93
CDK16
CDK4
CDK5
CDKN1A
CDSN
CEBPA
CHN2
CILK1
CLU
CRIPTO
CSNK2B
CSTF2
CTAG1A
CTAG1B
CTCFL
CTSB
CTSE
CTSL
CXCL8
CYSRT1
DMKN
DNAJB11
DPT
DRC9
EDN1
EFEMP1
EFEMP2
ELP1
EP300
FAM9B
FAS
FKBP2
FZD4
GADD45A
GLRA2
GOLGA6L9
GSK3B
HSPA13
HSPA8
IGF2
IGFBP5
IMMT
KLHL12
KPNA2
LBP
MAP1LC3B
MAPK6
MECOM
MEST
MTNR1A
MYDGF
NBL1
NCR3
NDUFA6
NDUFB11
NOMO1
NPY
NR1H2
PELP1
PIN1
PLA2G2A
PLK1
PLPP2
PLPPR3
POLR2J
PRKAR1B
PRMT2
PRNP
PRPF40A
PTH
PTN
PTPN12
RAB8A
RAC1
RCC1
RCN2
REG1B
RNF126
S100A4
SDC2
SEC61A1
SEC61B
SERPING1
SERPINH1
SERPINI2
SETDB1
SGTA
SMN1
SPP1
SRGN
STX5
TAC1
TENT5A
TFCP2
TK1
TOMM20
TP53
TP63
TTR
UBL7
UBQLN1
UBQLN2
UBQLN4
VAMP2
XRN1
ZFYVE9
166 interacting genes:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AGAP1
ANXA2
APLP1
ARFGAP1
ATP5F1B
ATP6V1A
BAG6
BCL2
BLOC1S6
BYSL
CARHSP1
CCDC90B
CENPB
CHTOP
COIL
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CSAD
DDAH2
DDX20
DHX9
DMPK
DOCK7
DUS2
DYNC1I1
EEF1A1
EEF1A2
EHHADH
EIF3G
EXT2
EZH2
FAM20C
FAM9B
FBL
FGB
FLAD1
FNDC11
FUBP1
FXR1
GAPDH
GAR1
GDF9
GEMIN2
GEMIN5
GEMIN7
H3-4
HADHB
HMGXB3
HNRNPR
HNRNPU
HNRNPUL1
IGHM
ILF3
IMMT
INPP5K
IQUB
ITCH
JADE1
KDM1A
KIF5A
KLHL5
KMT2B
KPNB1
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-1
KRTAP6-2
LENG8
LRIF1
LSM1
LSM10
LSM11
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MAGED1
MAST2
MED31
MKI67
MPP1
MRPL37
MSH2
NEURL2
NGFR
NKIRAS2
NMT2
NRN1
NTAQ1
OSTF1
PDE4DIP
PKM
PLXNA3
POLR1C
POLR2A
POP7
PPIG
PSME1
QARS1
RBBP4
RBBP6
RBFOX2
RBM48
REX1BD
RN7SL1
RNU1-1
RNU11
RNU2-1
RNU4-1
RPL13
RPS2
RXRA
SCARNA1
SDF4
SELENOW
SEMA5B
SETDB1
SMC5
SMN2
SNORA81
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNU13
SNUPN
SP110
SPANXN2
STRAP
STXBP2
STXBP3
SULT1A3
SUMO3
SYNCRIP
TAF1C
TERC
TIAL1
TLE1
TMSB4X
TP53
TRMT2A
TUBA1A
TUBB3
UCHL1
UNC119
USP4
VPS28
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZRANB2
ZXDC
Entrez ID
7917
6606
HPRD ID
00808
02646
Ensembl ID
ENSG00000204463
ENSG00000172062
Uniprot IDs
A0A1U9X7A6
A0A7P0MQS5
P46379
B4DP61
E7EQZ4
Q16637
PDB IDs
1WX9
2N9P
4DWF
4EEW
4WWR
4X86
6AU8
7RU9
7RUA
7RUC
1G5V
1MHN
2LEH
4A4E
4A4G
4GLI
4QQ6
5XJL
5XJQ
5XJR
5XJS
5XJT
5XJU
7W2P
7W30
Enriched GO Terms of Interacting Partners
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Regulation Of Cellular Response To Stress
Extracellular Space
Negative Regulation Of Multicellular Organismal Process
Regulation Of Proteolysis
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Extracellular Region
Protein Binding
Membrane Organization
Receptor Ligand Activity
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Response To Endoplasmic Reticulum Stress
Signal Transduction
Response To Hormone
Negative Regulation Of Proteolysis
Extracellular Matrix
Negative Regulation Of Cellular Component Organization
Response To Lipid
Tissue Development
Regulation Of Protein Catabolic Process
Tau Protein Binding
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Leukocyte Apoptotic Process
Positive Regulation Of Neutrophil Chemotaxis
Regulation Of Ossification
G1/S Transition Of Mitotic Cell Cycle
Protein-containing Complex
Establishment Of Protein Localization To Organelle
Molecular Function Activator Activity
Cell Cycle G1/S Phase Transition
Negative Regulation Of Developmental Process
Positive Regulation Of Granulocyte Chemotaxis
Regulation Of Multicellular Organismal Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Migration
Regulation Of Developmental Process
Response To Nutrient Levels
Cellular Response To Oxygen-containing Compound
Endoplasmic Reticulum Lumen
T Cell Apoptotic Process
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Cell Cycle
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Cell Motility
Regulation Of Signal Transduction
Spliceosomal SnRNP Assembly
RNA Binding
MRNA Metabolic Process
RNA Splicing
MRNA Processing
RNA Splicing, Via Transesterification Reactions
SMN-Sm Protein Complex
RNA Processing
Ribonucleoprotein Complex
U4/U6 X U5 Tri-snRNP Complex
Protein-RNA Complex Assembly
MRNA Splicing, Via Spliceosome
RNA Metabolic Process
U2-type Precatalytic Spliceosome
Spliceosomal Complex
Lsm2-8 Complex
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
U6 SnRNP
Lsm1-7-Pat1 Complex
Nucleoplasm
Precatalytic Spliceosome
SMN Complex
U4 SnRNP
Catalytic Step 2 Spliceosome
Telomerase Holoenzyme Complex
U7 SnRNP
Macromolecule Metabolic Process
7-methylguanosine Cap Hypermethylation
Small Nuclear Ribonucleoprotein Complex
Nucleus
Gemini Of Cajal Bodies
Methylosome
U12-type Spliceosomal Complex
PICln-Sm Protein Complex
Spliceosomal Tri-snRNP Complex
Cytosol
U2 SnRNP
Spliceosomal Complex Assembly
Protein-containing Complex Assembly
U1 SnRNP
U7 SnRNA Binding
U5 SnRNP
Cytoplasm
Cajal Body
Histone Pre-mRNA DCP Binding
U2-type Prespliceosome Assembly
Protein-containing Complex Organization
U6 SnRNA Binding
Promoter-specific Chromatin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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