BAG6 and PTH

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BAG6	PTH
Description		BAG cochaperone 6	parathyroid hormone
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome BAT3 Complex	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ribosome Binding Receptor Ligand Activity Misfolded Protein Binding Molecular Adaptor Activity Proteasome Binding Protein Carrier Chaperone Ubiquitin-specific Protease Binding	Hormone Activity Protein Binding Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Kidney Development Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Maintenance Of Unfolded Protein Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization NK T Cell Activation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway	Skeletal System Development Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Magnesium Ion Homeostasis Bone Mineralization Positive Regulation Of Bone Mineralization Response To Nutrient Levels Negative Regulation Of Chondrocyte Differentiation Response To Vitamin D Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II CAMP Metabolic Process Positive Regulation Of D-glucose Import Response To Cadmium Ion Homeostasis Of Number Of Cells Within A Tissue Phosphate Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Parathyroid Hormone Response To Fibroblast Growth Factor Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Osteoclast Proliferation Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Negative Regulation Of Bone Mineralization Involved In Bone Maturation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs			D-norleucine ABX-PTH
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bone mineral density ( 19874204) Childhood ear infection ( 27182965) Menarche (age at onset) ( 25231870) Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel ( 28935272)
Interacting Genes		120 interacting genes: ACVR1B AKT1 AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M BCL2 C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CEBPA CHN2 CILK1 CLU CRIPTO CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT DRC9 EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT KLHL12 KPNA2 LBP MAP1LC3B MAPK6 MECOM MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL7 UBQLN1 UBQLN2 UBQLN4 VAMP2 XRN1 ZFYVE9	6 interacting genes: ASPH BAG6 FEZ1 MEP1A PTH1R PTH2R
Entrez ID		7917	5741
HPRD ID		00808	01345
Ensembl ID		ENSG00000204463	ENSG00000152266
Uniprot IDs		A0A1U9X7A6 A0A7P0MQS5 P46379	P01270
PDB IDs		1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8 7RU9 7RUA 7RUC	1BWX 1ET1 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M 7VVK 7VVL 7VVM 7VVN 7VVO 7Y36 8FLQ 8HA0 8HAO 8T5F 9JR2 9JR3
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Extracellular Space Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Region Protein Binding Membrane Organization Receptor Ligand Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Endoplasmic Reticulum Stress Signal Transduction Response To Hormone Negative Regulation Of Proteolysis Extracellular Matrix Negative Regulation Of Cellular Component Organization Response To Lipid Tissue Development Regulation Of Protein Catabolic Process Tau Protein Binding Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Leukocyte Apoptotic Process Positive Regulation Of Neutrophil Chemotaxis Regulation Of Ossification G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Establishment Of Protein Localization To Organelle Molecular Function Activator Activity Cell Cycle G1/S Phase Transition Negative Regulation Of Developmental Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Multicellular Organismal Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Developmental Process Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Endoplasmic Reticulum Lumen T Cell Apoptotic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction	Parathyroid Hormone Receptor Activity Regulation Of Intracellular Transport Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Glycosylation-dependent Protein Binding Peptidyl-aspartic Acid 3-dioxygenase Activity Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control ERAD Pathway Regulation Of Cellular Localization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity BAT3 Complex Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Maintenance Of Unfolded Protein Positive Regulation Of Proteolysis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Sarcoplasmic Reticulum Lumen Intracellular Calcium Ion Homeostasis Junctional Sarcoplasmic Reticulum Membrane Calcium Ion Homeostasis Cortical Endoplasmic Reticulum Metallodipeptidase Activity Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Internal Peptidyl-lysine Acetylation Response To Endoplasmic Reticulum Stress Protein Targeting Protein Carrier Chaperone NK T Cell Activation Regulation Of Organelle Transport Along Microtubule Protein Retention In ER Lumen Negative Regulation Of Protein Exit From Endoplasmic Reticulum Hrd1p Ubiquitin Ligase Complex Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
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