BAG6 and RAB8A

Number of citations of the paper that reports this interaction (PubMedID 30804014)
93

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		BAG6	RAB8A
Description		BAG cochaperone 6	RAB8A, member RAS oncogene family
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome BAT3 Complex	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosome Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Membrane Trans-Golgi Network Transport Vesicle Dendrite Midbody Phagocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Ciliary Base Non-motile Cilium Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ribosome Binding Receptor Ligand Activity Misfolded Protein Binding Molecular Adaptor Activity Proteasome Binding Protein Carrier Chaperone Ubiquitin-specific Protease Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding Protein Tyrosine Kinase Binding
	Biological Process	Kidney Development Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Maintenance Of Unfolded Protein Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization NK T Cell Activation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway	Exocytosis Vesicle Docking Involved In Exocytosis Autophagy Golgi Organization Axonogenesis Regulation Of Autophagy Protein Transport Cell Projection Organization Endocytic Recycling Cellular Response To Insulin Stimulus Regulation Of Protein Localization Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		120 interacting genes: ACVR1B AKT1 AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M BCL2 C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CEBPA CHN2 CILK1 CLU CRIPTO CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT DRC9 EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT KLHL12 KPNA2 LBP MAP1LC3B MAPK6 MECOM MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL7 UBQLN1 UBQLN2 UBQLN4 VAMP2 XRN1 ZFYVE9	23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC
Entrez ID		7917	4218
HPRD ID		00808	01296
Ensembl ID		ENSG00000204463	ENSG00000167461
Uniprot IDs		A0A1U9X7A6 A0A7P0MQS5 P46379	P61006
PDB IDs		1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8 7RU9 7RUA 7RUC	3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6WHE 6YX5 6ZSI 6ZSJ 7BWT 7LWB 9IKQ
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Extracellular Space Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Region Protein Binding Membrane Organization Receptor Ligand Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Endoplasmic Reticulum Stress Signal Transduction Response To Hormone Negative Regulation Of Proteolysis Extracellular Matrix Negative Regulation Of Cellular Component Organization Response To Lipid Tissue Development Regulation Of Protein Catabolic Process Tau Protein Binding Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Leukocyte Apoptotic Process Positive Regulation Of Neutrophil Chemotaxis Regulation Of Ossification G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Establishment Of Protein Localization To Organelle Molecular Function Activator Activity Cell Cycle G1/S Phase Transition Negative Regulation Of Developmental Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Multicellular Organismal Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Developmental Process Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Endoplasmic Reticulum Lumen T Cell Apoptotic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction	Small GTPase Binding Establishment Of Protein Localization Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Exocytosis Cellular Localization Cytoplasmic Vesicle Golgi To Plasma Membrane Transport Secretion By Cell Endosome Trans-Golgi Network Recycling Endosome Membrane Secretion Polyubiquitin Modification-dependent Protein Binding Spontaneous Neurotransmitter Secretion Intracellular Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Intracellular Signal Transduction Establishment Of Localization In Cell Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Positive Regulation Of Protein Localization Golgi Vesicle Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytosol Membrane Interleukin-2-mediated Signaling Pathway Spindle Pole Organelle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Neurexin Family Protein Binding Signal Transduction Organelle Localization By Membrane Tethering Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Positive Regulation Of Protein Export From Nucleus Membrane Docking Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization To Membrane Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Cilium Assembly Regulation Of Cell Projection Assembly K63-linked Polyubiquitin Modification-dependent Protein Binding Establishment Of Vesicle Localization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?