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BAG6 and PLA2G2A
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
BAG6
PLA2G2A
Description
BAG cochaperone 6
phospholipase A2 group IIA
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Extracellular Exosome
BAT3 Complex
Extracellular Region
Extracellular Space
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Secretory Granule
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Signaling Receptor Binding
Protein Binding
Hsp70 Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ribosome Binding
Receptor Ligand Activity
Misfolded Protein Binding
Molecular Adaptor Activity
Proteasome Binding
Protein Carrier Chaperone
Ubiquitin-specific Protease Binding
Catalytic Activity
Phospholipase A2 Activity
Calcium Ion Binding
Phospholipid Binding
Hydrolase Activity
Metal Ion Binding
Calcium-dependent Phospholipase A2 Activity
Biological Process
Kidney Development
Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Chromatin Organization
Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Apoptotic Process
Synaptonemal Complex Assembly
Spermatogenesis
Brain Development
Proteasomal Protein Catabolic Process
Internal Peptidyl-lysine Acetylation
Natural Killer Cell Activation
Cell Differentiation
Lung Development
Regulation Of Protein Stability
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
ERAD Pathway
Maintenance Of Unfolded Protein
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteolysis
Regulation Of Embryonic Development
Protein Stabilization
NK T Cell Activation
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Tail-anchored Membrane Protein Insertion Into ER Membrane
Positive Regulation Of ERAD Pathway
Lipid Metabolic Process
Phospholipid Metabolic Process
Inflammatory Response
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Catabolic Process
Killing Of Cells Of Another Organism
Low-density Lipoprotein Particle Remodeling
Intestinal Stem Cell Homeostasis
Angiotensin-activated Signaling Pathway
Negative Regulation Of T Cell Proliferation
Defense Response To Bacterium
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidylglycerol Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonate Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Neutrophil Activation
Pathways
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Antimicrobial peptides
Drugs
Indomethacin
Ginkgo biloba
1,4-Butanediol
1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
N-Tridecanoic Acid
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
Lauric acid
(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid
6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid
Elaidamide
(2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate
KH064
Suramin
Varespladib methyl
Diseases
GWAS
A body shape index (
34021172
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Height (
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Schizophrenia (
23894747
)
Small cell lung carcinoma (
28604730
)
Smoking status (ever vs never smokers) (
30643258
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Blood protein levels (
30072576
)
Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP (
31070471
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Interacting Genes
120 interacting genes:
ACVR1B
AKT1
AMFR
AMTN
ANTKMT
ANXA7
APBB1IP
ARPC3
ATN1
ATXN2
B2M
BCL2
C1QA
CD93
CDK16
CDK4
CDK5
CDKN1A
CDSN
CEBPA
CHN2
CILK1
CLU
CRIPTO
CSNK2B
CSTF2
CTAG1A
CTAG1B
CTCFL
CTSB
CTSE
CTSL
CXCL8
CYSRT1
DMKN
DNAJB11
DPT
DRC9
EDN1
EFEMP1
EFEMP2
ELP1
EP300
FAM9B
FAS
FKBP2
FZD4
GADD45A
GLRA2
GOLGA6L9
GSK3B
HSPA13
HSPA8
IGF2
IGFBP5
IMMT
KLHL12
KPNA2
LBP
MAP1LC3B
MAPK6
MECOM
MEST
MTNR1A
MYDGF
NBL1
NCR3
NDUFA6
NDUFB11
NOMO1
NPY
NR1H2
PELP1
PIN1
PLA2G2A
PLK1
PLPP2
PLPPR3
POLR2J
PRKAR1B
PRMT2
PRNP
PRPF40A
PTH
PTN
PTPN12
RAB8A
RAC1
RCC1
RCN2
REG1B
RNF126
S100A4
SDC2
SEC61A1
SEC61B
SERPING1
SERPINH1
SERPINI2
SETDB1
SGTA
SMN1
SPP1
SRGN
STX5
TAC1
TENT5A
TFCP2
TK1
TOMM20
TP53
TP63
TTR
UBL7
UBQLN1
UBQLN2
UBQLN4
VAMP2
XRN1
ZFYVE9
26 interacting genes:
ALOX12
BAG6
CEP70
CRMP1
DCN
ITGAV
ITGB3
JOSD2
PLA2G1B
PLA2R1
SENP6
SENP8
UCHL1
UCHL3
UCHL5
USP15
USP2
USP20
USP28
USP4
USP47
USP5
USP7
USP8
VCAN
VIM
Entrez ID
7917
5320
HPRD ID
00808
01397
Ensembl ID
ENSG00000204463
ENSG00000188257
Uniprot IDs
A0A1U9X7A6
A0A7P0MQS5
P46379
P14555
PDB IDs
1WX9
2N9P
4DWF
4EEW
4WWR
4X86
6AU8
7RU9
7RUA
7RUC
1AYP
1BBC
1DB4
1DB5
1DCY
1J1A
1KQU
1KVO
1N28
1N29
1POD
1POE
3U8B
3U8D
3U8H
3U8I
5G3N
Enriched GO Terms of Interacting Partners
?
Regulation Of Cellular Response To Stress
Extracellular Space
Negative Regulation Of Multicellular Organismal Process
Regulation Of Proteolysis
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Extracellular Region
Protein Binding
Membrane Organization
Receptor Ligand Activity
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Response To Endoplasmic Reticulum Stress
Signal Transduction
Response To Hormone
Negative Regulation Of Proteolysis
Extracellular Matrix
Negative Regulation Of Cellular Component Organization
Response To Lipid
Tissue Development
Regulation Of Protein Catabolic Process
Tau Protein Binding
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Leukocyte Apoptotic Process
Positive Regulation Of Neutrophil Chemotaxis
Regulation Of Ossification
G1/S Transition Of Mitotic Cell Cycle
Protein-containing Complex
Establishment Of Protein Localization To Organelle
Molecular Function Activator Activity
Cell Cycle G1/S Phase Transition
Negative Regulation Of Developmental Process
Positive Regulation Of Granulocyte Chemotaxis
Regulation Of Multicellular Organismal Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Migration
Regulation Of Developmental Process
Response To Nutrient Levels
Cellular Response To Oxygen-containing Compound
Endoplasmic Reticulum Lumen
T Cell Apoptotic Process
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Cell Cycle
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Cell Motility
Regulation Of Signal Transduction
Protein Modification By Small Protein Removal
Protein Deubiquitination
Cysteine-type Deubiquitinase Activity
Cysteine-type Peptidase Activity
Peptidase Activity
Deubiquitinase Activity
Post-translational Protein Modification
Hydrolase Activity
Proteolysis
Cysteine-type Endopeptidase Activity
Protein Modification Process
Regulation Of Protein Stability
Protein Metabolic Process
Monoubiquitinated Protein Deubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Catabolic Process
Integrin Alphav-beta3 Complex
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Podocyte Apoptotic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
K48-linked Deubiquitinase Activity
Cytosol
Alphav-beta3 Integrin-PKCalpha Complex
Alphav-beta3 Integrin-HMGB1 Complex
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Biological Quality
Protein K48-linked Deubiquitination
Extracellular Matrix Binding
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Regulation Of Intracellular Signal Transduction
Apolipoprotein A-I-mediated Signaling Pathway
C-X3-C Chemokine Binding
Negative Regulation Of Lipoprotein Metabolic Process
Neuregulin Binding
Negative Regulation Of Lipid Transport
DeNEDDylase Activity
Macromolecule Metabolic Process
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteolysis
Positive Regulation Of Signal Transduction
Negative Regulation Of Low-density Lipoprotein Particle Clearance
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Insulin-like Growth Factor I Binding
Positive Regulation Of Osteoblast Proliferation
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Catabolic Process
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