BAG6 and IGF2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		BAG6	IGF2
Description		BAG cochaperone 6	insulin like growth factor 2
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome BAT3 Complex	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Signaling Receptor Binding Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ribosome Binding Receptor Ligand Activity Misfolded Protein Binding Molecular Adaptor Activity Proteasome Binding Protein Carrier Chaperone Ubiquitin-specific Protease Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Kidney Development Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Maintenance Of Unfolded Protein Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization NK T Cell Activation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Positive Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Embryonic Placenta Morphogenesis Genomic Imprinting Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases			Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Length of menstrual cycle ( 30202859) Periventricular white matter hyperintensities ( 32517579) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 30718926 32499647) Urate levels ( 31578528)
Interacting Genes		120 interacting genes: ACVR1B AKT1 AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M BCL2 C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CEBPA CHN2 CILK1 CLU CRIPTO CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT DRC9 EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT KLHL12 KPNA2 LBP MAP1LC3B MAPK6 MECOM MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL7 UBQLN1 UBQLN2 UBQLN4 VAMP2 XRN1 ZFYVE9	26 interacting genes: BAG6 CCN3 CCN5 CLN5 FAF1 GPC3 GPR152 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF TRIM55 TRIM63 VTN
Entrez ID		7917	3481
HPRD ID		00808	00939
Ensembl ID		ENSG00000204463	ENSG00000167244
Uniprot IDs		A0A1U9X7A6 A0A7P0MQS5 P46379	E3UN46 P01344
PDB IDs		1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8 7RU9 7RUA 7RUC	1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N 6UM2 6VWG 6VWI 8U4C 8U4E 8VJB 8VJC
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Extracellular Space Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Region Protein Binding Membrane Organization Receptor Ligand Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Endoplasmic Reticulum Stress Signal Transduction Response To Hormone Negative Regulation Of Proteolysis Extracellular Matrix Negative Regulation Of Cellular Component Organization Response To Lipid Tissue Development Regulation Of Protein Catabolic Process Tau Protein Binding Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Leukocyte Apoptotic Process Positive Regulation Of Neutrophil Chemotaxis Regulation Of Ossification G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Establishment Of Protein Localization To Organelle Molecular Function Activator Activity Cell Cycle G1/S Phase Transition Negative Regulation Of Developmental Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Multicellular Organismal Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Developmental Process Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Endoplasmic Reticulum Lumen T Cell Apoptotic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction	Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Insulin-like Growth Factor I Binding Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Signal Transduction Extracellular Space Type B Pancreatic Cell Proliferation Insulin Binding Insulin Receptor Signaling Pathway Endoplasmic Reticulum Lumen Extracellular Region Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Regeneration Signaling Receptor Binding Regulation Of Growth Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Insulin-like Growth Factor Receptor Activity Insulin Receptor Activity Insulin-like Growth Factor Binding Protein Complex Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Amyloid-beta Clearance Regulation Of Signal Transduction Negative Regulation Of Cell Population Proliferation Insulin Receptor Complex Fibronectin Binding Insulin-like Growth Factor Ternary Complex Positive Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of MAPK Cascade Tissue Regeneration Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Migration Positive Regulation Of Endocytosis Regulation Of Cell Motility
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