FBXW7 and FAM101A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		FBXW7	FAM101A
Gene Name		F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	family with sequence similarity 101, member A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Golgi Apparatus SCF Ubiquitin Ligase Complex Protein Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Cytoplasm Cytoskeleton
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Vasculogenesis Vasculature Development Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Protein Localization Cellular Response To UV Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway
Pathways		Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ARL6IP1 CCNE1 CCNE2 CDC34 CREB3L1 CREB3L2 CUL1 EBNA1BP2 FAM101A GLMN GNB2L1 HEY1 HIPK2 JUN KIAA1875 KLF5 LINGO1 MCL1 MED13 MED13L MMS22L MYB MYC NOTCH1 NOTCH4 PARK2 PPARGC1A PSEN1 SHPRH SKP1 STOML1 SUMF2 UBE2D1	3 interactors: FBXW7 FDFT1 FLNA
Entrez ID		55294	144347
HPRD ID		05888	14066
Ensembl ID		ENSG00000109670	ENSG00000178882
Uniprot IDs		B7Z2C8 G0Z2K0 Q969H0 S4R3U4	Q6ZTI6
PDB IDs		2OVP 2OVQ 2OVR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Neuron Death Cellular Response To Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Ubiquitination Negative Regulation Of Neuron Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Cellular Response To Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Death Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Gene Expression	Protein Stabilization Regulation Of Protein Stability Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Farnesyl Diphosphate Metabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Oxidative Stress-induced Cell Death Posttranscriptional Regulation Of Gene Expression Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of DNA Endoreduplication Regulation Of Hepatocyte Proliferation MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity MRNA Transcription Regulation Of Triglyceride Biosynthetic Process Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Actin Crosslink Formation Positive Regulation Of ERBB Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Sequestering Of Protein Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Regulation Of Epidermal Growth Factor-activated Receptor Activity Sister Chromatid Cohesion Negative Regulation Of Notch Signaling Pathway Cholesterol Biosynthetic Process Regulation Of Triglyceride Metabolic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Isoprenoid Biosynthetic Process Platelet Aggregation Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Receptor Activity Sterol Biosynthetic Process Mitotic Spindle Organization Cell Cycle Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of Cellular Response To Oxidative Stress Receptor Clustering Epithelial To Mesenchymal Transition Regulation Of Lipid Storage
Tagcloud ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	adolescent ais built causing clustering clusters comp date differing drastic dysregulation elucidate grouped homeobox hoxa10 hoxa13 hoxb7 hoxb8 idiopathic integrity malfunctioning osteoblasts participate particular pathogenesis pitx1 scoliosis vertebrae zic2
Tagcloud (Difference) ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	adolescent ais built causing clustering clusters comp date differing drastic dysregulation elucidate grouped homeobox hoxa10 hoxa13 hoxb7 hoxb8 idiopathic integrity malfunctioning osteoblasts participate particular pathogenesis pitx1 scoliosis vertebrae zic2
Tagcloud (Intersection) ?