FBXW7 and ANGPTL4

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		FBXW7	ANGPTL4
Description		F-box and WD repeat domain containing 7	angiopoietin like 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Extracellular Region Extracellular Space Extracellular Matrix Blood Microparticle
	Molecular Function	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Enzyme Inhibitor Activity Protein Binding Lipase Binding Identical Protein Binding Lipase Inhibitor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Vasculature Development DNA Repair DNA Damage Response Sister Chromatid Cohesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To UV Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Angiogenesis Response To Hypoxia Lipid Metabolic Process Blood Coagulation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Apoptotic Process Protein Unfolding Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Multicellular Organismal Process Triglyceride Homeostasis Endothelial Cell Apoptotic Process Regulation Of Chylomicron Remodeling Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Regulation of CDH11 function MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)	Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 20686565 30275531 28270201 25961943 19060906 24507774 24097068) HDL cholesterol levels ( 28334899 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Myocardial infarction ( 33532862) Phospholipid levels in large HDL ( 29084231) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels in HDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels ( 30698716 32154731 33339817 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24507774 25961943 27036123 30275531) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		84 interacting genes: ACD AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 DYRK2 EBNA1BP2 EXT1 EZH2 FANCC FBP2 FBXO45 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MALAT1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NIP7 NOTCH1 NOTCH4 NOX1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 RFLNA SCGB3A1 SEC61B SHC1 SHOC2 SHPRH SIK2 SKP1 SMAD1 SNCA SP7 SPI1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TRIP12 TSC22D4 USP2 WDR5 WDR97 XPA YAP1 ZNF510	9 interacting genes: AURKA BRMS1 CASP8 CDKN2A CDKN2C ESR1 FBXW7 FGFR4 TGFB1
Entrez ID		55294	51129
HPRD ID		05888	16173
Ensembl ID		ENSG00000109670	ENSG00000167772
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	Q9BY76
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B 7T1Y 7T1Z	6EUB 6U0A 6U1U 6U73
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Transcription Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Gland Development Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Differentiation Apoptotic Process Regulation Of Multicellular Organismal Process	Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Regulation Of Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Process Branch Elongation Of An Epithelium Response To Estradiol Positive Regulation Of Macrophage Differentiation Regulation Of Myeloid Leukocyte Differentiation Regulation Of Cell Development Regulation Of Developmental Process Mammary Gland Epithelial Cell Proliferation Apoptotic Process Branching Involved In Mammary Gland Duct Morphogenesis Axis Elongation Developmental Growth Involved In Morphogenesis Regulation Of Hemopoiesis Cell Death Programmed Cell Death Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Population Proliferation Protein Kinase Binding Regulation Of Extracellular Matrix Disassembly Lipid Homeostasis Regulation Of Macrophage Differentiation Negative Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MiRNA Transcription Epithelial Cell Proliferation Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Liver Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Carbohydrate Homeostasis
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