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FBXW7 and SUMF2
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
FBXW7
SUMF2
Gene Name
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
sulfatase modifying factor 2
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Golgi Apparatus
SCF Ubiquitin Ligase Complex
Protein Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Endoplasmic Reticulum Lumen
Molecular Function
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Cyclin Binding
Protein Binding, Bridging
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin-protein Transferase Activator Activity
Metal Ion Binding
Biological Process
Vasculogenesis
Vasculature Development
Regulation Of Transcription, DNA-templated
Cellular Response To DNA Damage Stimulus
Sister Chromatid Cohesion
Notch Signaling Pathway
Negative Regulation Of Triglyceride Biosynthetic Process
Regulation Of Lipid Storage
Viral Process
Protein Ubiquitination
Lung Development
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of DNA Endoreduplication
Regulation Of Protein Localization
Cellular Response To UV
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Notch Signaling Pathway
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Lipid Homeostasis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of SREBP Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Pathways
Protein folding
Antigen processing: Ubiquitination & Proteasome degradation
Chaperonin-mediated protein folding
Association of TriC/CCT with target proteins during biosynthesis
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Sphingolipid metabolism
Metabolism of lipids and lipoproteins
Glycosphingolipid metabolism
Post-translational protein modification
The activation of arylsulfatases
Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS
Protein-Protein Interactions
33 interactors:
ARL6IP1
CCNE1
CCNE2
CDC34
CREB3L1
CREB3L2
CUL1
EBNA1BP2
FAM101A
GLMN
GNB2L1
HEY1
HIPK2
JUN
KIAA1875
KLF5
LINGO1
MCL1
MED13
MED13L
MMS22L
MYB
MYC
NOTCH1
NOTCH4
PARK2
PPARGC1A
PSEN1
SHPRH
SKP1
STOML1
SUMF2
UBE2D1
4 interactors:
CACNA1A
FBXW7
ZDHHC17
ZFYVE9
Entrez ID
55294
25870
HPRD ID
05888
06400
Ensembl ID
ENSG00000109670
ENSG00000129103
Uniprot IDs
B7Z2C8
G0Z2K0
Q969H0
S4R3U4
Q8NBJ7
PDB IDs
2OVP
2OVQ
2OVR
1Y4J
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Notch Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Neuron Death
Cellular Response To Stress
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Positive Regulation Of Cellular Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Cellular Protein Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
RNA Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Proteolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Response To Organic Substance
Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cellular Response To Organic Substance
Regulation Of Protein Ubiquitination
Negative Regulation Of Neuron Death
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Regulation Of Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Cellular Response To Stimulus
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Death
Cell Cycle Phase Transition
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Gene Expression
Cerebellar Molecular Layer Development
Negative Regulation Of SREBP Signaling Pathway
Regulation Of Signaling
Negative Regulation Of Triglyceride Biosynthetic Process
Vestibular Nucleus Development
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cerebellum Maturation
Musculoskeletal Movement, Spinal Reflex Action
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Hepatocyte Proliferation
Gamma-aminobutyric Acid Secretion
Negative Regulation Of DNA Endoreduplication
Regulation Of Acetylcholine Secretion, Neurotransmission
Regulation Of Neuron Death
Rhythmic Synaptic Transmission
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Oxidative Stress-induced Cell Death
Calcium Ion-dependent Exocytosis Of Neurotransmitter
Cellular Chloride Ion Homeostasis
SMAD Protein Import Into Nucleus
Gamma-aminobutyric Acid Transport
Chloride Ion Homeostasis
Regulation Of DNA Endoreduplication
Regulation Of Hepatocyte Proliferation
Negative Regulation Of Hormone Biosynthetic Process
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Pons Development
SMAD Protein Complex Assembly
Protein Localization
Signal Transduction
Cerebellar Purkinje Cell Differentiation
Cerebellar Purkinje Cell Layer Morphogenesis
Regulation Of Triglyceride Biosynthetic Process
Signaling
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Lipoprotein Transport
Magnesium Ion Transport
Cell Communication
Reflex
Behavioral Response To Pain
Positive Regulation Of ERBB Signaling Pathway
Neuromuscular Synaptic Transmission
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Hormone Biosynthetic Process
Cerebellar Cortex Formation
Neurotransmitter Metabolic Process
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Sister Chromatid Cohesion
Protein Palmitoylation
Tagcloud
?
bcl11b
cadherin
discovered
dnm2
druggable
exhibitedthe
fat1
frequencies
guide
harboured
herc1
jak
jak3
lymphoblastic
mll2
mutational
notch1
notch2
phf6
recurrent
regulators
reln
secretase
splicing
subclonal
unfavourable
warranted
wt1
zrsr2
Tagcloud (Difference)
?
bcl11b
cadherin
discovered
dnm2
druggable
exhibitedthe
fat1
frequencies
guide
harboured
herc1
jak
jak3
lymphoblastic
mll2
mutational
notch1
notch2
phf6
recurrent
regulators
reln
secretase
splicing
subclonal
unfavourable
warranted
wt1
zrsr2
Tagcloud (Intersection)
?