FBXW7 and NOTCH1

  • Number of citations of the paper that reports this interaction (PMID 11425854)
  • 76
  • Data Source:
  • HPRD (in vivo, in vitro)

FBXW7

NOTCH1

Gene Name F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase notch 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 33 interactors: ARL6IP1 CCNE1 CCNE2 CDC34 CREB3L1 CREB3L2 CUL1 EBNA1BP2 FAM101A GLMN GNB2L1 HEY1 HIPK2 JUN KIAA1875 KLF5 LINGO1 MCL1 MED13 MED13L MMS22L MYB MYC NOTCH1 NOTCH4 PARK2 PPARGC1A PSEN1 SHPRH SKP1 STOML1 SUMF2 UBE2D1 56 interactors: ADAM17 AKT1 APBA1 BLOC1S1 CACNA1A CAMK4 CBL CNTN1 CTNNB1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 FBXW7 FURIN GFI1B GSK3B ILK ITCH JAG1 JAG2 KAT2A KAT2B LCK LEF1 LFNG MAML1 MAML2 MAML3 MDM2 MEF2C MFNG NFKB1 NOV NUMB NUMBL PIK3CG POFUT1 PSEN1 PSEN2 RBP3 RBPJ REL RELA RUNX3 SMAD3 SNAI1 SNW1 USP12 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID 55294 4851
HPRD ID 05888 01827
Ensembl ID ENSG00000109670 ENSG00000148400
Uniprot IDs B7Z2C8 G0Z2K0 Q969H0 S4R3U4 P46531
PDB IDs 2OVP 2OVQ 2OVR 1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79
Enriched GO Terms of Interacting Partners?
Tagcloud ?
bcl11b  cadherin  discovered  dnm2  druggable  exhibitedthe  fat1  frequencies  guide  harboured  herc1  jak  jak3  lymphoblastic  mll2  mutational  notch1  notch2  phf6  recurrent  regulators  reln  secretase  splicing  subclonal  unfavourable  warranted  wt1  zrsr2 
a23187  alpha1  antitrypsin  biologically  carboxyl  cleaved  convertase  convertases  decisions  dibasic  digestion  disagree  exists  extend  fate  furin  heterodimeric  invertebrates  ionophore  lovo  nearby  pdx  processed  processing  proteolytic  rqrr  takes  vertebrates 
Tagcloud (Difference) ?
bcl11b  cadherin  discovered  dnm2  druggable  exhibitedthe  fat1  frequencies  guide  harboured  herc1  jak  jak3  lymphoblastic  mll2  mutational  notch2  phf6  recurrent  regulators  reln  secretase  splicing  subclonal  unfavourable  warranted  wt1  zrsr2 
a23187  alpha1  antitrypsin  biologically  carboxyl  cleaved  convertase  convertases  decisions  dibasic  digestion  disagree  exists  extend  fate  furin  heterodimeric  invertebrates  ionophore  lovo  nearby  pdx  processed  processing  proteolytic  rqrr  takes  vertebrates 
Tagcloud (Intersection) ?
notch1