FBXW7 and EBNA1BP2

Number of citations of the paper that reports this interaction (PMID 21220517)
8

Data Source:
BioGRID (enzymatic study)

		FBXW7	EBNA1BP2
Gene Name		F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	EBNA1 binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Golgi Apparatus SCF Ubiquitin Ligase Complex Protein Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Nucleus Nucleolus Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin-protein Transferase Activator Activity	Poly(A) RNA Binding
	Biological Process	Vasculogenesis Vasculature Development Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Protein Localization Cellular Response To UV Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway	Ribosome Biogenesis
Pathways		Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ARL6IP1 CCNE1 CCNE2 CDC34 CREB3L1 CREB3L2 CUL1 EBNA1BP2 FAM101A GLMN GNB2L1 HEY1 HIPK2 JUN KIAA1875 KLF5 LINGO1 MCL1 MED13 MED13L MMS22L MYB MYC NOTCH1 NOTCH4 PARK2 PPARGC1A PSEN1 SHPRH SKP1 STOML1 SUMF2 UBE2D1	4 interactors: FAM9B FBXW7 FGF3 GSK3A
Entrez ID		55294	10969
HPRD ID		05888	16849
Ensembl ID		ENSG00000109670	ENSG00000117395
Uniprot IDs		B7Z2C8 G0Z2K0 Q969H0 S4R3U4	H7C2Q8 Q6IB29 Q99848
PDB IDs		2OVP 2OVQ 2OVR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Neuron Death Cellular Response To Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Ubiquitination Negative Regulation Of Neuron Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Cellular Response To Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Death Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Gene Expression	Negative Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Muscle Organ Development Regulation Of Cardiac Muscle Tissue Development Regulation Of Striated Muscle Tissue Development Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of SREBP Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Organ Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Triglyceride Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Protein Catabolic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Adrenergic Receptor Signaling Pathway Proteasomal Protein Catabolic Process Fc Receptor Signaling Pathway Response To Insulin Hypermethylation Of CpG Island Negative Regulation Of Hepatocyte Proliferation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of DNA Endoreduplication Cellular Response To Interleukin-3 Positive Regulation Of Glycogen (starch) Synthase Activity Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Oxidative Stress-induced Cell Death Response To Peptide Hormone Anatomical Structure Morphogenesis Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity
Tagcloud ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?