FBXW7 and AHSG

Number of citations of the paper that reports this interaction (PubMedID 29475832)
0

Data Source:
BioGRID (enzymatic study)

		FBXW7	AHSG
Description		F-box and WD repeat domain containing 7	alpha 2-HS glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Kinase Inhibitor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Vasculature Development DNA Repair DNA Damage Response Sister Chromatid Cohesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To UV Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Skeletal System Development Ossification Pinocytosis Acute-phase Response Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576)
Interacting Genes		84 interacting genes: ACD AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 DYRK2 EBNA1BP2 EXT1 EZH2 FANCC FBP2 FBXO45 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MALAT1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NIP7 NOTCH1 NOTCH4 NOX1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 RFLNA SCGB3A1 SEC61B SHC1 SHOC2 SHPRH SIK2 SKP1 SMAD1 SNCA SP7 SPI1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TRIP12 TSC22D4 USP2 WDR5 WDR97 XPA YAP1 ZNF510	9 interacting genes: CDC42 DCN FBXO2 FBXW7 GRB2 HSP90AA1 INSR RRAS2 VKORC1
Entrez ID		55294	197
HPRD ID		05888	00727
Ensembl ID		ENSG00000109670	ENSG00000145192
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	C9JV77 P02765
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B 7T1Y 7T1Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Transcription Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Gland Development Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Differentiation Apoptotic Process Regulation Of Multicellular Organismal Process	Positive Regulation Of Organelle Organization GTP Binding Insulin Receptor Substrate Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Assembly Neuron Projection Organization Regulation Of Lamellipodium Assembly Dendritic Spine Organization Postsynapse Organization Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Post-translational Protein Modification Small GTPase-mediated Signal Transduction Regulation Of Lamellipodium Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Receptor Internalization Regulation Of Cell Migration Neuronal Cell Body GBD Domain Binding Storage Vacuole Identical Protein Binding Lysosomal Lumen Positive Regulation Of Protein Polymerization Protein Phosphatase Binding Insulin Receptor Signaling Pathway Grb2-EGFR Complex Ras Protein Signal Transduction Regulation Of Protein Catabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Amyloid-beta Binding Denatured Protein Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity
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