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VIM and CAPN1
Number of citations of the paper that reports this interaction (PubMedID
28514442
)
50
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
HPRD
(two hybrid)
VIM
CAPN1
Description
vimentin
calpain 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Peroxisome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Intermediate Filament
Plasma Membrane
Focal Adhesion
Membrane
Nuclear Matrix
Axon
Cell Leading Edge
Cell Projection
Neuron Projection
Intermediate Filament Cytoskeleton
Phagocytic Vesicle
Extracellular Exosome
Cornified Envelope
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Calpain Complex
Ficolin-1-rich Granule Lumen
Molecular Function
RNA Binding
Double-stranded RNA Binding
Structural Constituent Of Cytoskeleton
Structural Constituent Of Eye Lens
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Molecular Adaptor Activity
Scaffold Protein Binding
Keratin Filament Binding
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Metal Ion Binding
Biological Process
Positive Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Astrocyte Development
Neuron Projection Development
Positive Regulation Of Collagen Biosynthetic Process
Regulation Of MRNA Stability
Intermediate Filament-based Process
Intermediate Filament Organization
Bergmann Glial Cell Differentiation
Lens Fiber Cell Development
Cellular Response To Lipopolysaccharide
Cellular Response To Muramyl Dipeptide
Cellular Response To Type II Interferon
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Receptor Catabolic Process
Regulation Of Catalytic Activity
Mammary Gland Involution
Self Proteolysis
NMDA Selective Glutamate Receptor Signaling Pathway
Pathways
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
RHOBTB1 GTPase cycle
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Developmental Lineage of Mammary Gland Myoepithelial Cells
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Artenimol
Phenethyl Isothiocyanate
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Cholesterol, total (
24097068
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Total cholesterol levels (
28334899
)
Triglyceride levels (
32203549
)
Urate levels (
31578528
)
Interacting Genes
188 interacting genes:
ABLIM1
AKT1
ANKRD35
ANXA7
APIP
APLP1
APP
ARMC7
ARMCX2
ATN1
BAG4
BFSP1
BHLHE40
BRD1
BYSL
CAMK2D
CAPN1
CASP3
CASP6
CASP7
CASP8
CASP9
CATSPERT
CBX8
CCDC187
CDH5
CDK1
CDKN1A
CEP126
CHD3
COPS6
CRCT1
CREB1
CRMP1
CT55
CWF19L2
DCTN1
DEFB1
DIS3L2
DNM1L
DPPA4
DSCAM
DSP
DUX4
DYNLL1
ENTR1
EPB41L2
ESS2
EXOSC7
FABP4
FAM107A
FAM118B
FAM161A
FUBP1
FXR1
FXR2
GADD45A
GEM
GFAP
GOPC
GRB2
GSK3B
HABP4
HAP1
HMG20B
HSPB1
HTRA2
ING5
IP6K1
ITGB4
IVNS1ABP
KARS1
KAT7
KIAA0408
KIF15
KIF9
KIFC3
KRT20
LGALS14
LINC01554
LORICRIN
LRIF1
MAFG
MAN2A2
MCPH1
MEN1
MICAL1
MRPL44
MTDH
NEFL
NEIL3
NFATC2
NFKBID
NIF3L1
NME2
NOC4L
NR1H2
NUP85
NXF1
OGT
OSBP2
PAK2
PDLIM1
PIAS4
PKD1
PKN1
PKP1
PKP2
PLA2G2A
PLA2G4A
PLEC
PLK1
PNMA5
POLR1C
PPHLN1
PPL
PPP1R18
PRKACA
PRPF6
PRPH
PSMA1
PSMC5
PSMD7
PSME1
PUF60
RAB8B
RABAC1
RAD51
RBM11
RBM22
RBM48
RIBC2
ROCK1
RPA1
SCNM1
SERBP1
SETDB1
SFPQ
SH3GL3
SH3YL1
SHANK3
SIRPA
SIRT6
SLC25A6
SLC27A6
SMAD3
SMARCB1
SNW1
SRRT
STX1A
SUMO2
SUMO3
SYN1
TAB2
TCEA2
TCHP
TLE5
TNFRSF14
TNNT1
TRIM14
TRIM15
TRIM28
TRIM29
TRIOBP
TSC1
TSC22D1
TTR
TUBA1C
TUBGCP4
TXLNB
TXN
TXN2
UBC
UPP1
UPP2
UROD
USP7
UTP14A
WBP11
WDR59
WHR1
XRCC4
YAE1
YWHAE
YWHAZ
ZHX1
ZNF384
ZNF572
55 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KCTD7
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
Entrez ID
7431
823
HPRD ID
01899
00253
Ensembl ID
ENSG00000026025
ENSG00000014216
Uniprot IDs
P08670
V9HWE1
B2RDI5
B4DWH5
P07384
PDB IDs
1GK4
1GK6
1GK7
3G1E
3KLT
3S4R
3SSU
3SWK
3TRT
3UF1
4MCY
4MCZ
4MD0
4MD5
4MDI
4MDJ
4YPC
4YV3
5WHF
6ATF
6ATI
6BIR
6YXK
8RVE
8TRQ
8TRR
1ZCM
2ARY
7W7O
7X79
8GX3
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Cytoplasm
Identical Protein Binding
Regulation Of Protein Localization To Nucleus
Protein Binding
Regulation Of Protein Localization
Negative Regulation Of Metabolic Process
Structural Constituent Of Cytoskeleton
Cytoskeleton
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Centrosome
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Intermediate Filament Organization
RNA Binding
Regulation Of RNA Metabolic Process
Execution Phase Of Apoptosis
Regulation Of Gene Expression
Positive Regulation Of Nucleocytoplasmic Transport
Response To Stress
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Organelle Organization
Nucleic Acid Metabolic Process
Cellular Response To Stress
Macromolecule Metabolic Process
Programmed Cell Death
Cytoskeleton Organization
Cell Death
Negative Regulation Of RNA Metabolic Process
Ubiquitin Protein Ligase Binding
Regulation Of Programmed Cell Death
Cytosol
Intermediate Filament
Apoptotic Process
Positive Regulation Of Protein Localization
Regulation Of Cell Differentiation
Positive Regulation Of Protein Export From Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
Cornified Envelope
Regulation Of Protein Export From Nucleus
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Differentiation
Organelle Organization
Regulation Of Programmed Cell Death
Response To Alcohol
Regulation Of Organelle Organization
Regulation Of Apoptotic Process
Identical Protein Binding
Positive Regulation Of Organelle Organization
Regulation Of Multicellular Organismal Process
Protease Binding
Cytoplasm
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Developmental Process
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Amino Acid Stimulus
Positive Regulation Of Gene Expression
Response To Lipid
Positive Regulation Of Programmed Cell Death
Negative Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA
Negative Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Hepatocyte Apoptotic Process
Cytosol
Regulation Of Actin Filament Depolymerization
Negative Regulation Of Apoptotic Process
Cell Junction Maintenance
Regulation Of Renin Secretion Into Blood Stream
Regulation Of Autophagy
Sarcomere
Negative Regulation Of Programmed Cell Death
Regulation Of Actin Filament-based Process
Regulation Of Mitochondrial Membrane Permeability
G-protein Beta-subunit Binding
Regulation Of Protein Localization
Response To Amino Acid
Release Of Cytochrome C From Mitochondria
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Response To Fluoride
Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Apoptotic Process
Cellular Component Maintenance
Regulation Of Membrane Permeability
Cysteine-type Peptidase Activity
Positive Regulation Of Cellular Component Organization
Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Protein Localization
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Tagcloud (Intersection)
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