VIM and CASP6

Number of citations of the paper that reports this interaction (PubMedID 10469173)
0

Data Source:
HPRD (in vitro, in vivo)

		VIM	CASP6
Description		vimentin	caspase 6
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Peroxisome Microtubule Organizing Center Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Membrane Nuclear Matrix Axon Cell Leading Edge Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Phagocytic Vesicle Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein Domain Specific Binding Identical Protein Binding Molecular Adaptor Activity Scaffold Protein Binding Keratin Filament Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Neuron Projection Development Positive Regulation Of Collagen Biosynthetic Process Regulation Of MRNA Stability Intermediate Filament-based Process Intermediate Filament Organization Bergmann Glial Cell Differentiation Lens Fiber Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide Cellular Response To Type II Interferon	Activation Of Innate Immune Response Proteolysis Apoptotic Process Protein Autoprocessing Epithelial Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Protein Maturation Positive Regulation Of Necroptotic Process Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Staurosporine Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Striated Muscle Contraction Interleukin-4 and Interleukin-13 signaling RHOBTB1 GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Developmental Lineage of Mammary Gland Myoepithelial Cells	Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549)	Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		188 interacting genes: ABLIM1 AKT1 ANKRD35 ANXA7 APIP APLP1 APP ARMC7 ARMCX2 ATN1 BAG4 BFSP1 BHLHE40 BRD1 BYSL CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CATSPERT CBX8 CCDC187 CDH5 CDK1 CDKN1A CEP126 CHD3 COPS6 CRCT1 CREB1 CRMP1 CT55 CWF19L2 DCTN1 DEFB1 DIS3L2 DNM1L DPPA4 DSCAM DSP DUX4 DYNLL1 ENTR1 EPB41L2 ESS2 EXOSC7 FABP4 FAM107A FAM118B FAM161A FUBP1 FXR1 FXR2 GADD45A GEM GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HSPB1 HTRA2 ING5 IP6K1 ITGB4 IVNS1ABP KARS1 KAT7 KIAA0408 KIF15 KIF9 KIFC3 KRT20 LGALS14 LINC01554 LORICRIN LRIF1 MAFG MAN2A2 MCPH1 MEN1 MICAL1 MRPL44 MTDH NEFL NEIL3 NFATC2 NFKBID NIF3L1 NME2 NOC4L NR1H2 NUP85 NXF1 OGT OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PKP2 PLA2G2A PLA2G4A PLEC PLK1 PNMA5 POLR1C PPHLN1 PPL PPP1R18 PRKACA PRPF6 PRPH PSMA1 PSMC5 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM11 RBM22 RBM48 RIBC2 ROCK1 RPA1 SCNM1 SERBP1 SETDB1 SFPQ SH3GL3 SH3YL1 SHANK3 SIRPA SIRT6 SLC25A6 SLC27A6 SMAD3 SMARCB1 SNW1 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCEA2 TCHP TLE5 TNFRSF14 TNNT1 TRIM14 TRIM15 TRIM28 TRIM29 TRIOBP TSC1 TSC22D1 TTR TUBA1C TUBGCP4 TXLNB TXN TXN2 UBC UPP1 UPP2 UROD USP7 UTP14A WBP11 WDR59 WHR1 XRCC4 YAE1 YWHAE YWHAZ ZHX1 ZNF384 ZNF572	43 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 RNF31 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM
Entrez ID		7431	839
HPRD ID		01899	03321
Ensembl ID		ENSG00000026025	ENSG00000138794
Uniprot IDs		P08670 V9HWE1	P55212
PDB IDs		1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1 4MCY 4MCZ 4MD0 4MD5 4MDI 4MDJ 4YPC 4YV3 5WHF 6ATF 6ATI 6BIR 6YXK 8RVE 8TRQ 8TRR	2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV 8EG5 8EG6 8F78 8F96 8F97 8F98 8F99 8F9A 8F9B 8F9C 8F9D 8FBV
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Cytoplasm Identical Protein Binding Regulation Of Protein Localization To Nucleus Protein Binding Regulation Of Protein Localization Negative Regulation Of Metabolic Process Structural Constituent Of Cytoskeleton Cytoskeleton Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Intermediate Filament Organization RNA Binding Regulation Of RNA Metabolic Process Execution Phase Of Apoptosis Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Organelle Organization Nucleic Acid Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Programmed Cell Death Cytoskeleton Organization Cell Death Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Cytosol Intermediate Filament Apoptotic Process Positive Regulation Of Protein Localization Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Cornified Envelope Regulation Of Protein Export From Nucleus Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation	Regulation Of Programmed Cell Death Cytoplasm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Nucleus Ripoptosome CD95 Death-inducing Signaling Complex Response To Stress Programmed Cell Death Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Death-inducing Signaling Complex Cytoskeleton Organization Ubiquitin Protein Ligase Binding Nuclear Matrix Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Modification Process Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Cytosol Regulation Of Protein Metabolic Process Intermediate Filament Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Macromolecule Metabolic Process Cellular Response To Stress Organelle Organization Structural Constituent Of Cytoskeleton Structural Constituent Of Nuclear Lamina Positive Regulation Of Metabolic Process Regulation Of Signaling Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cell Communication Response To Hypoxia Regulation Of Macroautophagy Positive Regulation Of DNA-binding Transcription Factor Activity Apolipoprotein Binding Death Receptor Binding Astrocyte Activation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?