VIM and SIRT6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		VIM	SIRT6
Description		vimentin	sirtuin 6
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Peroxisome Microtubule Organizing Center Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Membrane Nuclear Matrix Axon Cell Leading Edge Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Phagocytic Vesicle Extracellular Exosome	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Endoplasmic Reticulum Site Of Double-strand Break Site Of DNA Damage Chromosome, Subtelomeric Region
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein Domain Specific Binding Identical Protein Binding Molecular Adaptor Activity Scaffold Protein Binding Keratin Filament Binding	DNA Binding Chromatin Binding Damaged DNA Binding Transcription Corepressor Activity RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Deacetylase Activity, NAD-dependent Enzyme Regulator Activity Chromatin DNA Binding Nucleosome Binding Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism NAD-dependent Protein Lysine Deacetylase Activity Histone Deacetylase Regulator Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Deacetylase Activity, NAD-dependent NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD+-protein-arginine ADP-ribosyltransferase Activity DNA Damage Sensor Activity Histone H3K56 Deacetylase Activity, NAD-dependent NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity TORC2 Complex Binding NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Neuron Projection Development Positive Regulation Of Collagen Biosynthetic Process Regulation Of MRNA Stability Intermediate Filament-based Process Intermediate Filament Organization Bergmann Glial Cell Differentiation Lens Fiber Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide Cellular Response To Type II Interferon	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Base-excision Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling Protein Deacetylation Protein Import Into Nucleus Inflammatory Response DNA Damage Response Ras Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Response To UV Transposable Element Silencing Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Lipid Metabolic Process Pericentric Heterochromatin Formation Subtelomeric Heterochromatin Formation Protein Destabilization Positive Regulation Of Insulin Secretion Positive Regulation Of Telomere Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Transcription Elongation By RNA Polymerase II Ketone Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Glucose Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Regulation Of Protein Secretion Regulation Of Lipid Catabolic Process Protein Delipidation Cardiac Muscle Cell Differentiation Protein Poly-ADP-ribosylation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling Transcription Pausing By RNA Polymerase II Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Chondrocyte Proliferation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Protein Localization To Site Of Double-strand Break Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Striated Muscle Contraction Interleukin-4 and Interleukin-13 signaling RHOBTB1 GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Developmental Lineage of Mammary Gland Myoepithelial Cells	Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549)
Interacting Genes		188 interacting genes: ABLIM1 AKT1 ANKRD35 ANXA7 APIP APLP1 APP ARMC7 ARMCX2 ATN1 BAG4 BFSP1 BHLHE40 BRD1 BYSL CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CATSPERT CBX8 CCDC187 CDH5 CDK1 CDKN1A CEP126 CHD3 COPS6 CRCT1 CREB1 CRMP1 CT55 CWF19L2 DCTN1 DEFB1 DIS3L2 DNM1L DPPA4 DSCAM DSP DUX4 DYNLL1 ENTR1 EPB41L2 ESS2 EXOSC7 FABP4 FAM107A FAM118B FAM161A FUBP1 FXR1 FXR2 GADD45A GEM GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HSPB1 HTRA2 ING5 IP6K1 ITGB4 IVNS1ABP KARS1 KAT7 KIAA0408 KIF15 KIF9 KIFC3 KRT20 LGALS14 LINC01554 LORICRIN LRIF1 MAFG MAN2A2 MCPH1 MEN1 MICAL1 MRPL44 MTDH NEFL NEIL3 NFATC2 NFKBID NIF3L1 NME2 NOC4L NR1H2 NUP85 NXF1 OGT OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PKP2 PLA2G2A PLA2G4A PLEC PLK1 PNMA5 POLR1C PPHLN1 PPL PPP1R18 PRKACA PRPF6 PRPH PSMA1 PSMC5 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM11 RBM22 RBM48 RIBC2 ROCK1 RPA1 SCNM1 SERBP1 SETDB1 SFPQ SH3GL3 SH3YL1 SHANK3 SIRPA SIRT6 SLC25A6 SLC27A6 SMAD3 SMARCB1 SNW1 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCEA2 TCHP TLE5 TNFRSF14 TNNT1 TRIM14 TRIM15 TRIM28 TRIM29 TRIOBP TSC1 TSC22D1 TTR TUBA1C TUBGCP4 TXLNB TXN TXN2 UBC UPP1 UPP2 UROD USP7 UTP14A WBP11 WDR59 WHR1 XRCC4 YAE1 YWHAE YWHAZ ZHX1 ZNF384 ZNF572	18 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 DDB2 ELF5 FAF1 H3C1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A VIM
Entrez ID		7431	51548
HPRD ID		01899	12093
Ensembl ID		ENSG00000026025	ENSG00000077463
Uniprot IDs		P08670 V9HWE1	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1 4MCY 4MCZ 4MD0 4MD5 4MDI 4MDJ 4YPC 4YV3 5WHF 6ATF 6ATI 6BIR 6YXK 8RVE 8TRQ 8TRR	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY 6QCD 6QCE 6QCH 6QCJ 6XUY 6XV1 6XV6 6XVG 6ZU4 7CL0 7CL1 8AK5 8AK6 8AK7 8AK8 8AK9 8AKA 8AKB 8AKC 8AKD 8AKE 8AKF 8AKG 8BL0 8BL1 8CNM 8CNO 8F86 8G57 8I2B 8OF4 9G7H
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Cytoplasm Identical Protein Binding Regulation Of Protein Localization To Nucleus Protein Binding Regulation Of Protein Localization Negative Regulation Of Metabolic Process Structural Constituent Of Cytoskeleton Cytoskeleton Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Intermediate Filament Organization RNA Binding Regulation Of RNA Metabolic Process Execution Phase Of Apoptosis Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Organelle Organization Nucleic Acid Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Programmed Cell Death Cytoskeleton Organization Cell Death Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Cytosol Intermediate Filament Apoptotic Process Positive Regulation Of Protein Localization Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Cornified Envelope Regulation Of Protein Export From Nucleus Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation	Nucleus Nucleoplasm Protein Polyubiquitination Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Protein Metabolic Process DNA Damage Response DNA Repair Checkpoint Clamp Complex Positive Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Meiotic Cell Cycle Checkpoint Signaling Positive Regulation Of Protein Modification Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Reproductive Process Damaged DNA Binding DNA N-glycosylase Activity Protein Modification By Small Protein Conjugation Protein Autoubiquitination Positive Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Ubiquitin-protein Transferase Activity Base-excision Repair, AP Site Formation Regulation Of TORC1 Signaling Post-translational Protein Modification Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Regulation Of DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process DNA Modification Regulation Of Protein Polyubiquitination Negative Regulation Of Cell Cycle Response To Stress
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