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VIM and PLK1
Number of citations of the paper that reports this interaction (PubMedID
16260496
)
20
Data Source:
BioGRID
(proximity labelling technology, pull down, enzymatic study)
VIM
PLK1
Description
vimentin
polo like kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Peroxisome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Intermediate Filament
Plasma Membrane
Focal Adhesion
Membrane
Nuclear Matrix
Axon
Cell Leading Edge
Cell Projection
Neuron Projection
Intermediate Filament Cytoskeleton
Phagocytic Vesicle
Extracellular Exosome
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome, Centromeric Region
Chromatin
Synaptonemal Complex
Spindle Pole
Outer Kinetochore
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Cytoskeleton
Spindle Microtubule
Microtubule Cytoskeleton
Midbody
Centriolar Satellite
Spindle Midzone
Mitotic Spindle Pole
Molecular Function
RNA Binding
Double-stranded RNA Binding
Structural Constituent Of Cytoskeleton
Structural Constituent Of Eye Lens
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Molecular Adaptor Activity
Scaffold Protein Binding
Keratin Filament Binding
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Anaphase-promoting Complex Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Serine Kinase Activity
Biological Process
Positive Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Astrocyte Development
Neuron Projection Development
Positive Regulation Of Collagen Biosynthetic Process
Regulation Of MRNA Stability
Intermediate Filament-based Process
Intermediate Filament Organization
Bergmann Glial Cell Differentiation
Lens Fiber Cell Development
Cellular Response To Lipopolysaccharide
Cellular Response To Muramyl Dipeptide
Cellular Response To Type II Interferon
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Nuclear Division
Mitotic Cytokinesis
Double-strand Break Repair Via Homologous Recombination
Microtubule Bundle Formation
Double-strand Break Repair
Protein Phosphorylation
Mitotic Spindle Organization
Sister Chromatid Cohesion
Mitotic Chromosome Condensation
Mitotic Nuclear Membrane Disassembly
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Spindle Assembly Checkpoint Signaling
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Female Meiosis Chromosome Segregation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Protein Localization To Organelle
Negative Regulation Of Apoptotic Process
Homologous Chromosome Segregation
Establishment Of Protein Localization
Positive Regulation Of Proteolysis
Golgi Inheritance
Nuclear Membrane Disassembly
Centrosome Separation
Cell Division
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Synaptonemal Complex Disassembly
Protein Localization To Chromatin
Protein Localization To Centrosome
Protein Localization To Nuclear Envelope
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Protein Localization To Cell Cortex
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
RHOBTB1 GTPase cycle
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Developmental Lineage of Mammary Gland Myoepithelial Cells
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Artenimol
Phenethyl Isothiocyanate
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
Wortmannin
Fostamatinib
Volasertib
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Cholesterol, total (
24097068
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Total cholesterol levels (
28334899
)
Triglyceride levels (
32203549
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
188 interacting genes:
ABLIM1
AKT1
ANKRD35
ANXA7
APIP
APLP1
APP
ARMC7
ARMCX2
ATN1
BAG4
BFSP1
BHLHE40
BRD1
BYSL
CAMK2D
CAPN1
CASP3
CASP6
CASP7
CASP8
CASP9
CATSPERT
CBX8
CCDC187
CDH5
CDK1
CDKN1A
CEP126
CHD3
COPS6
CRCT1
CREB1
CRMP1
CT55
CWF19L2
DCTN1
DEFB1
DIS3L2
DNM1L
DPPA4
DSCAM
DSP
DUX4
DYNLL1
ENTR1
EPB41L2
ESS2
EXOSC7
FABP4
FAM107A
FAM118B
FAM161A
FUBP1
FXR1
FXR2
GADD45A
GEM
GFAP
GOPC
GRB2
GSK3B
HABP4
HAP1
HMG20B
HSPB1
HTRA2
ING5
IP6K1
ITGB4
IVNS1ABP
KARS1
KAT7
KIAA0408
KIF15
KIF9
KIFC3
KRT20
LGALS14
LINC01554
LORICRIN
LRIF1
MAFG
MAN2A2
MCPH1
MEN1
MICAL1
MRPL44
MTDH
NEFL
NEIL3
NFATC2
NFKBID
NIF3L1
NME2
NOC4L
NR1H2
NUP85
NXF1
OGT
OSBP2
PAK2
PDLIM1
PIAS4
PKD1
PKN1
PKP1
PKP2
PLA2G2A
PLA2G4A
PLEC
PLK1
PNMA5
POLR1C
PPHLN1
PPL
PPP1R18
PRKACA
PRPF6
PRPH
PSMA1
PSMC5
PSMD7
PSME1
PUF60
RAB8B
RABAC1
RAD51
RBM11
RBM22
RBM48
RIBC2
ROCK1
RPA1
SCNM1
SERBP1
SETDB1
SFPQ
SH3GL3
SH3YL1
SHANK3
SIRPA
SIRT6
SLC25A6
SLC27A6
SMAD3
SMARCB1
SNW1
SRRT
STX1A
SUMO2
SUMO3
SYN1
TAB2
TCEA2
TCHP
TLE5
TNFRSF14
TNNT1
TRIM14
TRIM15
TRIM28
TRIM29
TRIOBP
TSC1
TSC22D1
TTR
TUBA1C
TUBGCP4
TXLNB
TXN
TXN2
UBC
UPP1
UPP2
UROD
USP7
UTP14A
WBP11
WDR59
WHR1
XRCC4
YAE1
YWHAE
YWHAZ
ZHX1
ZNF384
ZNF572
147 interacting genes:
-
ACTL6B
AKAP12
APP
ASPM
BAG6
BCL2L1
BIRC6
BRCA2
BUB1
C6orf136
CBL
CCNB1
CDC14A
CDC25C
CDC6
CEBPA
CENPQ
CENPU
CEP55
CHEK2
CSN1S1
CSN2
CTNNB1
CUL4B
DNAJB9
DNHD1
ECT2
EIF6
ERCC6L
EYA1
EYA4
FBXL5
FBXW7
GET4
GLB1
GORASP1
HNRNPU
IDH1
IDH2
IKBKB
INTS11
ITSN1
KIF23
KIF2C
KLF4
KLHL22
KRABD3
LMO4
LRP5L
LRRK1
LRRK2
MAD2L1BP
MAGED1
MCM2
MCM3
MCM7
MDM2
MISP
MPP2
MYC
MYT1
NCAPD3
NCAPG2
NCAPH2
NEDD1
NEDD4
NHSL2
NINL
NPM1
NUDC
PARP10
PHC2
PIN1
PITPNM1
PKMYT1
PON1
PPID
PPIL2
PPP1R12A
PPP6R2
PRC1
PRKN
PSMA1
PSMA3
PSMA4
PSMA5
PSMA6
PSMA7
PSMB1
PSMB2
PSMB3
PSMB4
PSMB5
PSMB6
PSMB7
PSRC1
PTEN
PTPRD
RAB1A
RABAC1
RACGAP1
RAD51
RAP1GAP
RECQL5
RELA
REST
RGCC
RICTOR
RNF126
RNF2
RSF1
RXRA
SEPTIN9
SHCBP1
SIMC1
SNCA
SNCB
SPOUT1
SREBF1
STAG2
STUB1
SUGT1
TIMELESS
TNFSF11
TOP2A
TP53
TP53BP2
TP73
TPT1
TRIOBP
TSC1
TUBA4A
TUBB
TUBB3
TUBG1
UBE2I
UHRF1
USP16
USP7
VIM
VMA22
VRK2
VRK3
WAC
WEE1
ZNF71
Entrez ID
7431
5347
HPRD ID
01899
03652
Ensembl ID
ENSG00000026025
ENSG00000166851
Uniprot IDs
P08670
V9HWE1
P53350
PDB IDs
1GK4
1GK6
1GK7
3G1E
3KLT
3S4R
3SSU
3SWK
3TRT
3UF1
4MCY
4MCZ
4MD0
4MD5
4MDI
4MDJ
4YPC
4YV3
5WHF
6ATF
6ATI
6BIR
6YXK
8RVE
8TRQ
8TRR
1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4O56
4O6W
4O9W
4RCP
4WHH
4WHK
4WHL
4X9R
4X9V
4X9W
5J19
5NEI
5NFU
5NJE
5NMM
5NN1
5NN2
5TA6
5TA8
6AX4
6GY2
7MSO
7MX1
8BJT
8CRC
8JOQ
8JOY
8S30
8S31
8WFP
8X72
8XB9
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Cytoplasm
Identical Protein Binding
Regulation Of Protein Localization To Nucleus
Protein Binding
Regulation Of Protein Localization
Negative Regulation Of Metabolic Process
Structural Constituent Of Cytoskeleton
Cytoskeleton
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Centrosome
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Intermediate Filament Organization
RNA Binding
Regulation Of RNA Metabolic Process
Execution Phase Of Apoptosis
Regulation Of Gene Expression
Positive Regulation Of Nucleocytoplasmic Transport
Response To Stress
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Organelle Organization
Nucleic Acid Metabolic Process
Cellular Response To Stress
Macromolecule Metabolic Process
Programmed Cell Death
Cytoskeleton Organization
Cell Death
Negative Regulation Of RNA Metabolic Process
Ubiquitin Protein Ligase Binding
Regulation Of Programmed Cell Death
Cytosol
Intermediate Filament
Apoptotic Process
Positive Regulation Of Protein Localization
Regulation Of Cell Differentiation
Positive Regulation Of Protein Export From Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
Cornified Envelope
Regulation Of Protein Export From Nucleus
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Differentiation
Proteasome Core Complex
Cell Division
Cytoplasm
Regulation Of Cell Cycle
Nucleoplasm
Regulation Of Cell Cycle Process
Nucleus
Cytosol
Cellular Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteasome Complex
Proteasomal Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Macromolecule Catabolic Process
Positive Regulation Of Cell Cycle
Proteasome Core Complex, Beta-subunit Complex
Positive Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle
Spindle
Regulation Of Cell Cycle Phase Transition
Proteasome Core Complex, Alpha-subunit Complex
Regulation Of Cellular Response To Stress
Microtubule-based Process
Organelle Organization
Centrosome
Cytoskeleton
Microtubule Cytoskeleton Organization
Midbody
Proteolysis
Regulation Of Intracellular Signal Transduction
Cellular Response To Radiation
DNA Repair
Chromosome Segregation
Regulation Of Chromosome Organization
Regulation Of Cytokinesis
Macromolecule Metabolic Process
Response To Xenobiotic Stimulus
Regulation Of Organelle Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Chromosome Segregation
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Cell Cycle
Positive Regulation Of Programmed Cell Death
Protein Kinase Binding
Chromosome
Regulation Of Chromosome Segregation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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