VIM and XRCC4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		VIM	XRCC4
Gene Name		vimentin	X-ray repair complementing defective repair in Chinese hamster cells 4
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Cell Leading Edge Neuron Projection Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Condensed Chromosome Nucleus Nucleoplasm Centrosome Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Cell Junction DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	Glycoprotein Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein C-terminus Binding Identical Protein Binding Scaffold Protein Binding	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Viral Process Muscle Filament Sliding Intermediate Filament Organization Bergmann Glial Cell Differentiation SMAD Protein Signal Transduction Lens Fiber Cell Development	In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Central Nervous System Development Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency
Pathways		Apoptotic cleavage of cellular proteins Striated Muscle Contraction Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle
Drugs			S-(Dimethylarsenic)Cysteine
Diseases
GWAS			Hypertension ( 21626137)
Protein-Protein Interactions		140 interactors: ABLIM1 AKT1 ALS2CR11 ANKRD35 ANXA7 APIP APLP1 APP ARMCX2 ATN1 BFSP1 BHLHE40 BRD1 CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CDH5 CDK1 CDKN1A CHD3 COPS6 CRCT1 CREB1 CRMP1 CWF19L2 DCTN1 DEFB1 DGCR14 DIS3L2 DNM1L DPPA4 DSP DYNLL1 EIF3I FABP4 FAM107A FAM118B FUBP1 GADD45A GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HTRA2 ING5 ITGB4 IVNS1ABP KARS KAT7 KIAA0408 KIAA1377 KIF15 KRT20 LOR LRIF1 MAFG MAN2A2 MEN1 MICAL1 MRPL44 NEFL NFATC2 NIF3L1 NME2 NOC4L NR1H2 NUP85 OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PLA2G2A PLA2G4A PLEC PNMA5 POLR1C PPHLN1 PPL PRKACA PRPH PSMA1 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM48 RIBC2 ROCK1 RPA1 SDCCAG3 SERBP1 SETDB1 SH3GL1 SH3GL3 SH3YL1 SIRT6 SLC25A6 SLC27A6 SMAD3 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCHP TNFRSF14 TNNT1 TRIM28 TRIM29 TRIOBP TSC22D1 TTR TUBGCP4 TXLNB TXN TXN2 UPP1 UPP2 UROD UTP14A WBP11 XRCC4 YAE1D1 YWHAE YWHAZ ZHX1 ZNF384	19 interactors: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GZMB IFFO1 LIG4 NBN NHEJ1 PNKP PRKDC VIM
Entrez ID		7431	7518
HPRD ID		01899	15951
Ensembl ID		ENSG00000026025	ENSG00000152422
Uniprot IDs		P08670	Q13426 Q7Z763
PDB IDs		1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1	1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Apoptotic Process Cell Death Death Execution Phase Of Apoptosis Regulation Of Cell Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Positive Regulation Of Proteolysis Regulation Of Cellular Localization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Organelle Organization Cell Cycle Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Gene Expression Immune System Process Regulation Of Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Positive Regulation Of Signal Transduction Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Programmed Cell Death Cellular Process Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Viral Process Intrinsic Apoptotic Signaling Pathway	Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Polynucleotide 3' Dephosphorylation Single Strand Break Repair Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Apoptotic Process Programmed Cell Death Cellular Response To Stress B Cell Activation Cell Death Death Pro-B Cell Differentiation Cell Activation Immunoglobulin Production Response To Radiation Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination DNA Recombination Lymphoid Progenitor Cell Differentiation Response To Stress DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Autophosphorylation Regulation Of Voltage-gated Calcium Channel Activity DNA Catabolic Process Response To Ionizing Radiation Isotype Switching Lymphocyte Activation T Cell Differentiation V(D)J Recombination Mitotic Cell Cycle Checkpoint Regulation Of Protein Autophosphorylation Cellular Response To Stimulus Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Regulation Of Cell Cycle Process Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Central Nervous System Development Response To Stimulus Regulation Of Cell Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?		10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?		10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded f13a1 flank linkage lip lod multipoint palate rara syndromic theta unrelated van vws woude z	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub mendelian networks omim omnibus ranked santa topological visualization xpc xrcc5 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?		inheritance