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VIM and PAK2
Number of citations of the paper that reports this interaction (PubMedID
2500966
)
0
Data Source:
HPRD
(in vitro)
VIM
PAK2
Description
vimentin
p21 (RAC1) activated kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Peroxisome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Intermediate Filament
Plasma Membrane
Focal Adhesion
Membrane
Nuclear Matrix
Axon
Cell Leading Edge
Cell Projection
Neuron Projection
Intermediate Filament Cytoskeleton
Phagocytic Vesicle
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Postsynaptic Density
Membrane
Nuclear Speck
Secretory Granule
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Molecular Function
RNA Binding
Double-stranded RNA Binding
Structural Constituent Of Cytoskeleton
Structural Constituent Of Eye Lens
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Molecular Adaptor Activity
Scaffold Protein Binding
Keratin Filament Binding
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Biological Process
Positive Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Astrocyte Development
Neuron Projection Development
Positive Regulation Of Collagen Biosynthetic Process
Regulation Of MRNA Stability
Intermediate Filament-based Process
Intermediate Filament Organization
Bergmann Glial Cell Differentiation
Lens Fiber Cell Development
Cellular Response To Lipopolysaccharide
Cellular Response To Muramyl Dipeptide
Cellular Response To Type II Interferon
Stimulatory C-type Lectin Receptor Signaling Pathway
Cardiac Muscle Hypertrophy
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Starvation
Cell Migration
Adherens Junction Assembly
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Protein Maturation
Dendritic Spine Development
Bicellular Tight Junction Assembly
Cellular Response To Transforming Growth Factor Beta Stimulus
Execution Phase Of Apoptosis
Regulation Of Actin Filament Organization
Protein Localization To Cell-cell Junction
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
RHOBTB1 GTPase cycle
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Developmental Lineage of Mammary Gland Myoepithelial Cells
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Drugs
Artenimol
Phenethyl Isothiocyanate
Fostamatinib
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Cholesterol, total (
24097068
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Total cholesterol levels (
28334899
)
Triglyceride levels (
32203549
)
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil count (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
27863252
32888494
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
27863252
32888494
)
Neutrophil count (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
27863252
32888494
)
Interacting Genes
188 interacting genes:
ABLIM1
AKT1
ANKRD35
ANXA7
APIP
APLP1
APP
ARMC7
ARMCX2
ATN1
BAG4
BFSP1
BHLHE40
BRD1
BYSL
CAMK2D
CAPN1
CASP3
CASP6
CASP7
CASP8
CASP9
CATSPERT
CBX8
CCDC187
CDH5
CDK1
CDKN1A
CEP126
CHD3
COPS6
CRCT1
CREB1
CRMP1
CT55
CWF19L2
DCTN1
DEFB1
DIS3L2
DNM1L
DPPA4
DSCAM
DSP
DUX4
DYNLL1
ENTR1
EPB41L2
ESS2
EXOSC7
FABP4
FAM107A
FAM118B
FAM161A
FUBP1
FXR1
FXR2
GADD45A
GEM
GFAP
GOPC
GRB2
GSK3B
HABP4
HAP1
HMG20B
HSPB1
HTRA2
ING5
IP6K1
ITGB4
IVNS1ABP
KARS1
KAT7
KIAA0408
KIF15
KIF9
KIFC3
KRT20
LGALS14
LINC01554
LORICRIN
LRIF1
MAFG
MAN2A2
MCPH1
MEN1
MICAL1
MRPL44
MTDH
NEFL
NEIL3
NFATC2
NFKBID
NIF3L1
NME2
NOC4L
NR1H2
NUP85
NXF1
OGT
OSBP2
PAK2
PDLIM1
PIAS4
PKD1
PKN1
PKP1
PKP2
PLA2G2A
PLA2G4A
PLEC
PLK1
PNMA5
POLR1C
PPHLN1
PPL
PPP1R18
PRKACA
PRPF6
PRPH
PSMA1
PSMC5
PSMD7
PSME1
PUF60
RAB8B
RABAC1
RAD51
RBM11
RBM22
RBM48
RIBC2
ROCK1
RPA1
SCNM1
SERBP1
SETDB1
SFPQ
SH3GL3
SH3YL1
SHANK3
SIRPA
SIRT6
SLC25A6
SLC27A6
SMAD3
SMARCB1
SNW1
SRRT
STX1A
SUMO2
SUMO3
SYN1
TAB2
TCEA2
TCHP
TLE5
TNFRSF14
TNNT1
TRIM14
TRIM15
TRIM28
TRIM29
TRIOBP
TSC1
TSC22D1
TTR
TUBA1C
TUBGCP4
TXLNB
TXN
TXN2
UBC
UPP1
UPP2
UROD
USP7
UTP14A
WBP11
WDR59
WHR1
XRCC4
YAE1
YWHAE
YWHAZ
ZHX1
ZNF384
ZNF572
54 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
CEBPA
DOCK2
DSCR9
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
OGT
PACSIN3
PPM1A
RAC1
RAF1
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
7431
5062
HPRD ID
01899
05428
Ensembl ID
ENSG00000026025
ENSG00000180370
Uniprot IDs
P08670
V9HWE1
A8K5M4
Q13177
PDB IDs
1GK4
1GK6
1GK7
3G1E
3KLT
3S4R
3SSU
3SWK
3TRT
3UF1
4MCY
4MCZ
4MD0
4MD5
4MDI
4MDJ
4YPC
4YV3
5WHF
6ATF
6ATI
6BIR
6YXK
8RVE
8TRQ
8TRR
3PCS
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Cytoplasm
Identical Protein Binding
Regulation Of Protein Localization To Nucleus
Protein Binding
Regulation Of Protein Localization
Negative Regulation Of Metabolic Process
Structural Constituent Of Cytoskeleton
Cytoskeleton
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Centrosome
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Intermediate Filament Organization
RNA Binding
Regulation Of RNA Metabolic Process
Execution Phase Of Apoptosis
Regulation Of Gene Expression
Positive Regulation Of Nucleocytoplasmic Transport
Response To Stress
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Organelle Organization
Nucleic Acid Metabolic Process
Cellular Response To Stress
Macromolecule Metabolic Process
Programmed Cell Death
Cytoskeleton Organization
Cell Death
Negative Regulation Of RNA Metabolic Process
Ubiquitin Protein Ligase Binding
Regulation Of Programmed Cell Death
Cytosol
Intermediate Filament
Apoptotic Process
Positive Regulation Of Protein Localization
Regulation Of Cell Differentiation
Positive Regulation Of Protein Export From Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
Cornified Envelope
Regulation Of Protein Export From Nucleus
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Differentiation
Regulation Of Cellular Component Organization
Cytosol
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Signal Transduction
Regulation Of Vesicle-mediated Transport
Cytoskeleton Organization
Positive Regulation Of Cellular Component Organization
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Cytoplasm
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Enzyme-linked Receptor Protein Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of MAPK Cascade
Focal Adhesion
Protein Phosphorylation
Ephrin Receptor Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Organelle Organization
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Phosphorylation
Positive Regulation Of Cytoskeleton Organization
Signal Transduction
Anchoring Junction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Organelle Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Immune Response-activating Signaling Pathway
Actin Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Endocytosis
Regulation Of Cell Activation
Regulation Of Transport
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Supramolecular Fiber Organization
Regulation Of Endocytosis
Regulation Of T Cell Activation
Ephrin Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Supramolecular Fiber Organization
Actin Filament-based Process
Protein Kinase Activity
Lamellipodium
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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