VIM and POLR1C

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		VIM	POLR1C
Description		vimentin	RNA polymerase I and III subunit C
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Peroxisome Microtubule Organizing Center Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Membrane Nuclear Matrix Axon Cell Leading Edge Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Phagocytic Vesicle Extracellular Exosome	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytoplasm Cytosol
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein Domain Specific Binding Identical Protein Binding Molecular Adaptor Activity Scaffold Protein Binding Keratin Filament Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Neuron Projection Development Positive Regulation Of Collagen Biosynthetic Process Regulation Of MRNA Stability Intermediate Filament-based Process Intermediate Filament Organization Bergmann Glial Cell Differentiation Lens Fiber Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide Cellular Response To Type II Interferon	DNA-templated Transcription Transcription By RNA Polymerase I
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Striated Muscle Contraction Interleukin-4 and Interleukin-13 signaling RHOBTB1 GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Developmental Lineage of Mammary Gland Myoepithelial Cells	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases			Treacher Collins syndrome
GWAS		Aspartate aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549)	GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		188 interacting genes: ABLIM1 AKT1 ANKRD35 ANXA7 APIP APLP1 APP ARMC7 ARMCX2 ATN1 BAG4 BFSP1 BHLHE40 BRD1 BYSL CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CATSPERT CBX8 CCDC187 CDH5 CDK1 CDKN1A CEP126 CHD3 COPS6 CRCT1 CREB1 CRMP1 CT55 CWF19L2 DCTN1 DEFB1 DIS3L2 DNM1L DPPA4 DSCAM DSP DUX4 DYNLL1 ENTR1 EPB41L2 ESS2 EXOSC7 FABP4 FAM107A FAM118B FAM161A FUBP1 FXR1 FXR2 GADD45A GEM GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HSPB1 HTRA2 ING5 IP6K1 ITGB4 IVNS1ABP KARS1 KAT7 KIAA0408 KIF15 KIF9 KIFC3 KRT20 LGALS14 LINC01554 LORICRIN LRIF1 MAFG MAN2A2 MCPH1 MEN1 MICAL1 MRPL44 MTDH NEFL NEIL3 NFATC2 NFKBID NIF3L1 NME2 NOC4L NR1H2 NUP85 NXF1 OGT OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PKP2 PLA2G2A PLA2G4A PLEC PLK1 PNMA5 POLR1C PPHLN1 PPL PPP1R18 PRKACA PRPF6 PRPH PSMA1 PSMC5 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM11 RBM22 RBM48 RIBC2 ROCK1 RPA1 SCNM1 SERBP1 SETDB1 SFPQ SH3GL3 SH3YL1 SHANK3 SIRPA SIRT6 SLC25A6 SLC27A6 SMAD3 SMARCB1 SNW1 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCEA2 TCHP TLE5 TNFRSF14 TNNT1 TRIM14 TRIM15 TRIM28 TRIM29 TRIOBP TSC1 TSC22D1 TTR TUBA1C TUBGCP4 TXLNB TXN TXN2 UBC UPP1 UPP2 UROD USP7 UTP14A WBP11 WDR59 WHR1 XRCC4 YAE1 YWHAE YWHAZ ZHX1 ZNF384 ZNF572	118 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A DRC4 EFHC2 EP400 FH FMR1 FOXR2 GMPPB GOLGA6A GOLGA6L9 GPRASP3 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPMIP10 SPMIP2 SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TFIP11 TIAM1 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835
Entrez ID		7431	9533
HPRD ID		01899	09661
Ensembl ID		ENSG00000026025	ENSG00000171453
Uniprot IDs		P08670 V9HWE1	A0A2R8YEZ4 O15160
PDB IDs		1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1 4MCY 4MCZ 4MD0 4MD5 4MDI 4MDJ 4YPC 4YV3 5WHF 6ATF 6ATI 6BIR 6YXK 8RVE 8TRQ 8TRR	7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Cytoplasm Identical Protein Binding Regulation Of Protein Localization To Nucleus Protein Binding Regulation Of Protein Localization Negative Regulation Of Metabolic Process Structural Constituent Of Cytoskeleton Cytoskeleton Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Intermediate Filament Organization RNA Binding Regulation Of RNA Metabolic Process Execution Phase Of Apoptosis Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Organelle Organization Nucleic Acid Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Programmed Cell Death Cytoskeleton Organization Cell Death Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Cytosol Intermediate Filament Apoptotic Process Positive Regulation Of Protein Localization Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Cornified Envelope Regulation Of Protein Export From Nucleus Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation	Protein Binding Nucleus Identical Protein Binding Supramolecular Fiber Organization DNA-directed RNA Polymerase Complex Regulation Of Nucleobase-containing Compound Metabolic Process SMN Complex Actin Filament Organization RNA Polymerase I Complex Regulation Of Actin Nucleation Regulation Of Primary Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?