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TP53BP2 and WWP2
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
TP53BP2
WWP2
Description
tumor protein p53 binding protein 2
WW domain containing E3 ubiquitin protein ligase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Cytosol
Membrane
Extracellular Exosome
Molecular Function
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
NF-kappaB Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Transferase Activity
Potassium Channel Inhibitor Activity
Transmembrane Transporter Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin Protein Ligase Activity
Transcription Regulator Inhibitor Activity
Biological Process
Apoptotic Process
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Extracellular Transport
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Transporter Activity
Regulation Of Monoatomic Ion Transmembrane Transport
Protein Modification Process
Regulation Of Membrane Potential
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Symbiont Entry Into Host Cell
Negative Regulation Of Protein Transport
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Regulation of PTEN stability and activity
RHOQ GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Triptolide cytotoxicity (
26121980
)
Appendicular lean mass (
33097823
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Cataracts (
34127677
)
Cataracts (operation) (
31816047
)
Diastolic blood pressure (
30578418
)
Diverticular disease (
30177863
)
Estimated glomerular filtration rate (
31152163
)
FEV1 (
30804560
)
Hand grip strength (
29691431
)
Height (
31562340
28552196
)
IgE levels (
23146381
)
Knee osteoarthritis (
30374069
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Lung function (FVC) (
30804560
)
Lung function in never smokers (low FEV1 vs high FEV1) (
26423011
)
Menarche (age at onset) (
25231870
)
Myocardial infarction (
33532862
)
Plantar fascial disorders (
29534260
)
Platelet count (
32888494
)
Pulse pressure (
30578418
)
Smoking behaviour (cigarette pack-years) (
30679032
)
Smoking initiation (
33082346
)
Triglyceride levels (
31928498
)
Triglycerides (
30275531
)
Waist circumference (
31928498
)
Interacting Genes
119 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC92
CDC5L
CEP55
CEP95
CGN
CREBBP
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBC
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
115 interacting genes:
ANKRD44
ARRDC3
ATN1
ATOSB
ATXN3
C3orf70
CALCOCO2
CDC34
CFAP36
CFTR
CLCN5
CPSF6
DAG1
DIDO1
DVL2
EFCAB3
EGR2
ENTREP1
EWSR1
FAF1
FAM131B
FAM131C
FBXL18
FUT3
GADD45GIP1
GAS2L2
GGN
GRAP2
HGS
HNRNPUL1
IFIT2
IL2RG
IL6R
IST1
KHDRBS3
LGALS9B
MED25
MED4
MIR19A
MIR19B1
MIR92A1
NDFIP1
NDFIP2
NHERF2
OPTN
PAIP1
PATZ1
PDCD6IP
PDLIM7
PRKAA2
PSMD4
PSMF1
PTEN
RABEP2
RAD23A
RAD23B
RASA1
RASD1
RNF11
RUSC1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEC24D
SF1
SFMBT1
SFTPC
SMAD3
SMAD7
SMR3A
SNRPB
SNRPC
SOX2
SPART
SQSTM1
STAM
TFAP2A
THBS1
TICAM1
TNK2
TOM1
TOM1L2
TP53BP2
TRAF4
TRIP10
UBAC1
UBAP1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2I
UBE2J2
UBE2K
UBE2L3
UBL7
UBQLN1
UBQLN4
UBTD1
USP5
USP7
VASP
VPS37C
WASF2
WBP1
WBP2
WDR5
WIPF1
ZNF688
Entrez ID
7159
11060
HPRD ID
11803
03812
Ensembl ID
ENSG00000143514
ENSG00000198373
Uniprot IDs
Q13625
B4DHF6
O00308
PDB IDs
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
4Y07
5TJ7
5TJ8
5TJQ
6J1Z
6RSS
8EI5
8EI6
8EI7
8EI8
9EQH
Enriched GO Terms of Interacting Partners
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Protein Binding
Cytosol
Cytoplasm
Regulation Of Protein Metabolic Process
Nucleus
Regulation Of Signal Transduction
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Protein Kinase Binding
Positive Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Signal Transduction
Regulation Of Signaling
Postsynaptic Cytosol
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Response To Radiation
Cytoskeleton
Regulation Of Protein Modification Process
Centrosome
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Nucleoplasm
Protein Modification Process
Protein Modification By Small Protein Conjugation
Regulation Of JNK Cascade
Plasma Membrane Bounded Cell Projection Organization
Identical Protein Binding
PTW/PP1 Phosphatase Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Entrainment Of Circadian Clock By Photoperiod
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Cell Projection Organization
Regulation Of Primary Metabolic Process
Protein Domain Specific Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Photoperiodism
Entrainment Of Circadian Clock
Channel Inhibitor Activity
NF-kappaB P50/p65 Complex
Regulation Of Neurogenesis
Regulation Of Post-translational Protein Modification
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Proteolysis
WW Domain Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Macromolecule Catabolic Process
Ubiquitin Binding
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Endosome
Catabolic Process
Nucleoplasm
Protein Ubiquitination
Cytosol
Post-translational Protein Modification
Protein K48-linked Ubiquitination
Multivesicular Body Assembly
Multivesicular Body Organization
Protein Metabolic Process
Regulation Of Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Protein Binding
Sensory Perception Of Salty Taste
Regulation Of Proteasomal Protein Catabolic Process
Endosome Organization
Macroautophagy
Regulation Of Proteolysis
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Positive Regulation Of Metabolic Process
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Perinuclear Region Of Cytoplasm
Proteasome Binding
Autophagy
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Ubiquitination
Ubiquitin-protein Transferase Activity
Cellular Response To Aldosterone
Sodium Channel Complex
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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