TP53BP2 and RGMA

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TP53BP2	RGMA
Name		tumor protein p53 binding protein 2	repulsive guidance molecule BMP co-receptor a
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding	Signaling Receptor Binding Protein Binding Coreceptor Activity Transferrin Receptor Binding
	Biological Process	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis	Neural Tube Closure Membrane Protein Ectodomain Proteolysis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Neuron Projection Development Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Primary Metabolic Process
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Netrin-1 signaling
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Triptolide cytotoxicity ( 26121980 )	Blood protein levels ( 30072576 ) Copper levels ( 26025379 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Heel bone mineral density ( 30598549 ) Metabolite levels ( 23823483 ) Opioid dependence ( 29478698 ) Overweight status ( 25133637 ) Periodontitis (CDC/AAP) ( 24024966 ) Refractive error ( 32231278 ) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498 ) Type 1 diabetes nephropathy ( 23028342 ) Type 2 diabetes ( 32499647 )
Interacting Genes		119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575	4 interacting genes: PPP1R16A SGSM2 TERF2IP TP53BP2
Entrez ID		7159	56963
HPRD ID		11803	09560
Ensembl ID		ENSG00000143514	ENSG00000182175
Uniprot IDs		Q13625	A0A0A0MTQ4 Q96B86
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP	4UHY 6Z3G
GO Terms Enriched among Interactors		Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression	None