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WWP2 and IL6R
Number of citations of the paper that reports this interaction (PubMedID
9169421
)
0
Data Source:
HPRD
(in vitro)
WWP2
IL6R
Description
WW domain containing E3 ubiquitin protein ligase 2
interleukin 6 receptor
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Cytosol
Membrane
Extracellular Exosome
Extracellular Region
Extracellular Space
Plasma Membrane
Interleukin-6 Receptor Complex
External Side Of Plasma Membrane
Membrane
Apical Plasma Membrane
Receptor Complex
Ciliary Neurotrophic Factor Receptor Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Transferase Activity
Potassium Channel Inhibitor Activity
Transmembrane Transporter Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin Protein Ligase Activity
Transcription Regulator Inhibitor Activity
Cytokine Receptor Activity
Ciliary Neurotrophic Factor Receptor Activity
Interleukin-6 Receptor Activity
Interleukin-11 Receptor Activity
Interleukin-6 Receptor Binding
Protein Binding
Enzyme Binding
Interleukin-11 Binding
Interleukin-6 Binding
Protein Homodimerization Activity
Ciliary Neurotrophic Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Extracellular Transport
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Transporter Activity
Regulation Of Monoatomic Ion Transmembrane Transport
Protein Modification Process
Regulation Of Membrane Potential
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Symbiont Entry Into Host Cell
Negative Regulation Of Protein Transport
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Hepatic Immune Response
Neutrophil Mediated Immunity
Monocyte Chemotaxis
Positive Regulation Of Leukocyte Chemotaxis
Acute-phase Response
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Vascular Endothelial Growth Factor Production
Cytokine-mediated Signaling Pathway
Endocrine Pancreas Development
Developmental Process
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Negative Regulation Of Collagen Biosynthetic Process
Response To Cytokine
Interleukin-11-mediated Signaling Pathway
Positive Regulation Of MAPK Cascade
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Smooth Muscle Cell Proliferation
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Interleukin-6-mediated Signaling Pathway
Ciliary Neurotrophic Factor-mediated Signaling Pathway
Positive Regulation Of Glomerular Mesangial Cell Proliferation
T-helper 17 Cell Lineage Commitment
Extrinsic Apoptotic Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Positive Regulation Of Platelet Aggregation
Pathways
Regulation of PTEN stability and activity
RHOQ GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
NOTCH3 Activation and Transmission of Signal to the Nucleus
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Interleukin-4 and Interleukin-13 signaling
Transcriptional regulation of granulopoiesis
Potential therapeutics for SARS
Drugs
Tocilizumab
Sarilumab
Satralizumab
Diseases
GWAS
Appendicular lean mass (
33097823
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Cataracts (
34127677
)
Cataracts (operation) (
31816047
)
Diastolic blood pressure (
30578418
)
Diverticular disease (
30177863
)
Estimated glomerular filtration rate (
31152163
)
FEV1 (
30804560
)
Hand grip strength (
29691431
)
Height (
31562340
28552196
)
IgE levels (
23146381
)
Knee osteoarthritis (
30374069
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Lung function (FVC) (
30804560
)
Lung function in never smokers (low FEV1 vs high FEV1) (
26423011
)
Menarche (age at onset) (
25231870
)
Myocardial infarction (
33532862
)
Plantar fascial disorders (
29534260
)
Platelet count (
32888494
)
Pulse pressure (
30578418
)
Smoking behaviour (cigarette pack-years) (
30679032
)
Smoking initiation (
33082346
)
Triglyceride levels (
31928498
)
Triglycerides (
30275531
)
Waist circumference (
31928498
)
Abdominal aortic aneurysm (
27899403
)
Acute anterior uveitis (with or without ankylosing spondylitis) (
25200001
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Ankylosing spondylitis (
23749187
)
Asthma (
32296059
21907864
)
Atopic dermatitis (
26482879
)
Atrial fibrillation (
29892015
)
Blood protein levels (
30072576
23696881
)
Blood protein levels in cardiovascular risk (
28369058
)
C-reactive protein (
19567438
18439548
)
C-reactive protein levels (
30388399
29878111
29403010
21300955
33339817
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Coronary artery disease (
26343387
32469254
29212778
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Fibrinogen (
20031577
23969696
)
Fibrinogen levels (
28107422
26561523
)
Interleukin-6 levels (
33517400
32473944
)
Interleukin-6 levels in HIV infection (
33095540
)
Iron status biomarkers (iron levels) (
33536631
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Mosquito bite size (
28199695
)
Myocardial infarction (
26343387
33532862
)
Parental longevity (combined parental attained age, Martingale residuals) (
29227965
)
Platelet count (
32888494
)
Protein quantitative trait loci (
18464913
)
Pulmonary function (
17903307
)
Red cell distribution width (
32888494
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Rheumatoid arthritis (
24390342
23143596
30423114
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Serum alkaline phosphatase levels (
33547301
)
Systemic lupus erythematosus (
28714469
)
Type 1 diabetes (
34127860
)
Interacting Genes
115 interacting genes:
ANKRD44
ARRDC3
ATN1
ATOSB
ATXN3
C3orf70
CALCOCO2
CDC34
CFAP36
CFTR
CLCN5
CPSF6
DAG1
DIDO1
DVL2
EFCAB3
EGR2
ENTREP1
EWSR1
FAF1
FAM131B
FAM131C
FBXL18
FUT3
GADD45GIP1
GAS2L2
GGN
GRAP2
HGS
HNRNPUL1
IFIT2
IL2RG
IL6R
IST1
KHDRBS3
LGALS9B
MED25
MED4
MIR19A
MIR19B1
MIR92A1
NDFIP1
NDFIP2
NHERF2
OPTN
PAIP1
PATZ1
PDCD6IP
PDLIM7
PRKAA2
PSMD4
PSMF1
PTEN
RABEP2
RAD23A
RAD23B
RASA1
RASD1
RNF11
RUSC1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEC24D
SF1
SFMBT1
SFTPC
SMAD3
SMAD7
SMR3A
SNRPB
SNRPC
SOX2
SPART
SQSTM1
STAM
TFAP2A
THBS1
TICAM1
TNK2
TOM1
TOM1L2
TP53BP2
TRAF4
TRIP10
UBAC1
UBAP1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2I
UBE2J2
UBE2K
UBE2L3
UBL7
UBQLN1
UBQLN4
UBTD1
USP5
USP7
VASP
VPS37C
WASF2
WBP1
WBP2
WDR5
WIPF1
ZNF688
11 interacting genes:
ADRB2
CNTF
ERAP1
IL6
IL6ST
MAGI1
SGTB
SRC
STAT3
WWP1
WWP2
Entrez ID
11060
3570
HPRD ID
03812
01000
Ensembl ID
ENSG00000198373
ENSG00000160712
Uniprot IDs
B4DHF6
O00308
A0A087WTB5
A0N0L5
P08887
PDB IDs
4Y07
5TJ7
5TJ8
5TJQ
6J1Z
6RSS
8EI5
8EI6
8EI7
8EI8
9EQH
1N26
1P9M
2ARW
5FUC
7DC8
8D82
8IOW
8QY5
8QY6
Enriched GO Terms of Interacting Partners
?
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Proteolysis
WW Domain Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Macromolecule Catabolic Process
Ubiquitin Binding
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Endosome
Catabolic Process
Nucleoplasm
Protein Ubiquitination
Cytosol
Post-translational Protein Modification
Protein K48-linked Ubiquitination
Multivesicular Body Assembly
Multivesicular Body Organization
Protein Metabolic Process
Regulation Of Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Protein Binding
Sensory Perception Of Salty Taste
Regulation Of Proteasomal Protein Catabolic Process
Endosome Organization
Macroautophagy
Regulation Of Proteolysis
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Positive Regulation Of Metabolic Process
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Perinuclear Region Of Cytoplasm
Proteasome Binding
Autophagy
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Ubiquitination
Ubiquitin-protein Transferase Activity
Cellular Response To Aldosterone
Sodium Channel Complex
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Interleukin-6 Receptor Binding
Interleukin-6-mediated Signaling Pathway
T-helper 17 Cell Lineage Commitment
Cell Surface Receptor Signaling Pathway Via JAK-STAT
T-helper Cell Lineage Commitment
Cell Surface Receptor Signaling Pathway Via STAT
CD4-positive, Alpha-beta T Cell Lineage Commitment
Alpha-beta T Cell Lineage Commitment
CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment
Regulation Of Notch Signaling Pathway
Negative Regulation Of Primary MiRNA Processing
T Cell Lineage Commitment
Positive Regulation Of Vascular Endothelial Growth Factor Production
Interleukin-6 Receptor Complex
Cell Differentiation
Ciliary Neurotrophic Factor-mediated Signaling Pathway
Positive Regulation Of Notch Signaling Pathway
Regulation Of Vascular Endothelial Growth Factor Production
Ciliary Neurotrophic Factor Receptor Binding
Interleukin-11-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Negative Regulation Of MiRNA Processing
Cellular Developmental Process
Retinal Rod Cell Differentiation
Positive Regulation Of Extracellular Matrix Disassembly
Intestinal Epithelial Cell Development
Inflammatory Response To Wounding
Positive Regulation Of Platelet Aggregation
Positive Regulation Of Developmental Process
Regulation Of MiRNA Processing
Developmental Process
Camera-type Eye Photoreceptor Cell Differentiation
Negative Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA
Regulation Of Regulatory NcRNA Processing
Protein Tyrosine Kinase Activator Activity
Columnar/cuboidal Epithelial Cell Development
Negative Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Eye Photoreceptor Cell Differentiation
Positive Regulation Of Homotypic Cell-cell Adhesion
Negative Regulation Of Anoikis
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Phosphate Metabolic Process
Photoreceptor Cell Differentiation
Symbiont Entry Into Host Cell
Positive Regulation Of Cell-cell Adhesion
Regulation Of Extracellular Matrix Disassembly
Bone Resorption
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Tagcloud (Intersection)
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