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WWP2 and SCNN1B
Number of citations of the paper that reports this interaction (PubMedID
12167593
)
0
Data Source:
HPRD
(in vitro, in vivo)
WWP2
SCNN1B
Description
WW domain containing E3 ubiquitin protein ligase 2
sodium channel epithelial 1 subunit beta
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Cytosol
Membrane
Extracellular Exosome
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Sodium Channel Complex
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Transferase Activity
Potassium Channel Inhibitor Activity
Transmembrane Transporter Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin Protein Ligase Activity
Transcription Regulator Inhibitor Activity
Sodium Channel Activity
Protein Binding
Ligand-gated Sodium Channel Activity
WW Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Extracellular Transport
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Transporter Activity
Regulation Of Monoatomic Ion Transmembrane Transport
Protein Modification Process
Regulation Of Membrane Potential
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Symbiont Entry Into Host Cell
Negative Regulation Of Protein Transport
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Leukocyte Activation Involved In Inflammatory Response
Neutrophil Activation Involved In Immune Response
Renal System Process
Monoatomic Ion Transport
Sodium Ion Transport
Intracellular Sodium Ion Homeostasis
Regulation Of Blood Pressure
Response To Xenobiotic Stimulus
Gene Expression
Artery Smooth Muscle Contraction
Response To Food
Aldosterone Metabolic Process
Erythrocyte Homeostasis
Monoatomic Ion Transmembrane Transport
Multicellular Organism Growth
Sodium Ion Transmembrane Transport
Epithelial Fluid Transport
Multicellular Organismal-level Water Homeostasis
Sensory Perception Of Salty Taste
Sensory Perception Of Sour Taste
Potassium Ion Homeostasis
Sodium Ion Homeostasis
Mucus Secretion
Neutrophil-mediated Killing Of Bacterium
Cellular Response To Acidic PH
Sodium Ion Import Across Plasma Membrane
Cellular Response To Aldosterone
Cellular Response To Vasopressin
Pathways
Regulation of PTEN stability and activity
RHOQ GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
NOTCH3 Activation and Transmission of Signal to the Nucleus
Stimuli-sensing channels
Sensory perception of salty taste
Drugs
Triamterene
Amiloride
Diseases
Liddle syndrome
Bronchiectasis with or without elevated sweat chloride
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Appendicular lean mass (
33097823
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Cataracts (
34127677
)
Cataracts (operation) (
31816047
)
Diastolic blood pressure (
30578418
)
Diverticular disease (
30177863
)
Estimated glomerular filtration rate (
31152163
)
FEV1 (
30804560
)
Hand grip strength (
29691431
)
Height (
31562340
28552196
)
IgE levels (
23146381
)
Knee osteoarthritis (
30374069
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Lung function (FVC) (
30804560
)
Lung function in never smokers (low FEV1 vs high FEV1) (
26423011
)
Menarche (age at onset) (
25231870
)
Myocardial infarction (
33532862
)
Plantar fascial disorders (
29534260
)
Platelet count (
32888494
)
Pulse pressure (
30578418
)
Smoking behaviour (cigarette pack-years) (
30679032
)
Smoking initiation (
33082346
)
Triglyceride levels (
31928498
)
Triglycerides (
30275531
)
Waist circumference (
31928498
)
Kidney stones (
31729369
)
Interacting Genes
115 interacting genes:
ANKRD44
ARRDC3
ATN1
ATOSB
ATXN3
C3orf70
CALCOCO2
CDC34
CFAP36
CFTR
CLCN5
CPSF6
DAG1
DIDO1
DVL2
EFCAB3
EGR2
ENTREP1
EWSR1
FAF1
FAM131B
FAM131C
FBXL18
FUT3
GADD45GIP1
GAS2L2
GGN
GRAP2
HGS
HNRNPUL1
IFIT2
IL2RG
IL6R
IST1
KHDRBS3
LGALS9B
MED25
MED4
MIR19A
MIR19B1
MIR92A1
NDFIP1
NDFIP2
NHERF2
OPTN
PAIP1
PATZ1
PDCD6IP
PDLIM7
PRKAA2
PSMD4
PSMF1
PTEN
RABEP2
RAD23A
RAD23B
RASA1
RASD1
RNF11
RUSC1
SCAMP3
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEC24D
SF1
SFMBT1
SFTPC
SMAD3
SMAD7
SMR3A
SNRPB
SNRPC
SOX2
SPART
SQSTM1
STAM
TFAP2A
THBS1
TICAM1
TNK2
TOM1
TOM1L2
TP53BP2
TRAF4
TRIP10
UBAC1
UBAP1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2I
UBE2J2
UBE2K
UBE2L3
UBL7
UBQLN1
UBQLN4
UBTD1
USP5
USP7
VASP
VPS37C
WASF2
WBP1
WBP2
WDR5
WIPF1
ZNF688
14 interacting genes:
ANK3
CNTN1
COMMD10
EPN1
HECW1
ITCH
NEDD4
NEDD4L
NFASC
SCNN1A
SCNN1D
SCNN1G
STX1A
WWP2
Entrez ID
11060
6338
HPRD ID
03812
02861
Ensembl ID
ENSG00000198373
ENSG00000168447
Uniprot IDs
B4DHF6
O00308
B2R812
H3BQ95
P51168
PDB IDs
4Y07
5TJ7
5TJ8
5TJQ
6J1Z
6RSS
8EI5
8EI6
8EI7
8EI8
9EQH
6BQN
6WTH
9BLR
9BTG
9BTU
Enriched GO Terms of Interacting Partners
?
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Proteolysis
WW Domain Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Macromolecule Catabolic Process
Ubiquitin Binding
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Endosome
Catabolic Process
Nucleoplasm
Protein Ubiquitination
Cytosol
Post-translational Protein Modification
Protein K48-linked Ubiquitination
Multivesicular Body Assembly
Multivesicular Body Organization
Protein Metabolic Process
Regulation Of Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Protein Binding
Sensory Perception Of Salty Taste
Regulation Of Proteasomal Protein Catabolic Process
Endosome Organization
Macroautophagy
Regulation Of Proteolysis
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Positive Regulation Of Metabolic Process
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Perinuclear Region Of Cytoplasm
Proteasome Binding
Autophagy
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Ubiquitination
Ubiquitin-protein Transferase Activity
Cellular Response To Aldosterone
Sodium Channel Complex
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Negative Regulation Of Potassium Ion Transmembrane Transport
Sodium Ion Import Across Plasma Membrane
Sensory Perception Of Salty Taste
Negative Regulation Of Potassium Ion Transport
Import Into Cell
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Cellular Response To Aldosterone
Sodium Channel Complex
Sensory Perception Of Sour Taste
Cellular Response To Vasopressin
Potassium Channel Inhibitor Activity
Transmembrane Transporter Binding
Regulation Of Potassium Ion Export Across Plasma Membrane
Cellular Response To Mineralocorticoid Stimulus
Ligand-gated Sodium Channel Activity
Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Sodium Ion Transport
Sodium Ion Transport
Negative Regulation Of Cation Transmembrane Transport
Response To Aldosterone
Negative Regulation Of Monoatomic Ion Transmembrane Transport
Cellular Response To Acidic PH
Regulation Of Potassium Ion Transport
Intracellular Sodium Ion Homeostasis
Inorganic Cation Import Across Plasma Membrane
Negative Regulation Of Monoatomic Ion Transport
Response To Acidic PH
Ubiquitin-protein Transferase Activity
Cellular Response To PH
Negative Regulation Of Transmembrane Transport
Sensory Perception Of Taste
Sodium Channel Activity
Sodium Ion Homeostasis
Neuromuscular Junction Development
Response To Mineralocorticoid
Sodium Ion Transmembrane Transport
Response To PH
Import Across Plasma Membrane
Regulation Of Metal Ion Transport
Ubiquitin Protein Ligase Activity
Protein Modification By Small Protein Conjugation
Protein Monoubiquitination
Regulation Of Monoatomic Ion Transport
Regulation Of Membrane Potential
Sodium Channel Inhibitor Activity
Regulation Of Dendrite Morphogenesis
Endocytosis
Cellular Response To Corticosteroid Stimulus
Receptor Internalization
Protein K63-linked Ubiquitination
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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