TP53BP2 and POLR2L

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TP53BP2	POLR2L
Description		tumor protein p53 binding protein 2	RNA polymerase II, I and III subunit L
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol
	Molecular Function	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase I Transcription By RNA Polymerase I Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)	Pulse pressure ( 30578418)
Interacting Genes		119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575	27 interacting genes: AGR2 BANP CCDC85B CCN3 CHEK2 COIL EXOSC5 FAM217B L3MBTL3 NACC1 NFKBIB PHC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2H PSMA6 REL RPAP1 SNX7 SPAG5 THAP1 TP53BP2 TRIP13 ZBTB14
Entrez ID		7159	5441
HPRD ID		11803	01155
Ensembl ID		ENSG00000143514	ENSG00000177700
Uniprot IDs		Q13625	P62875
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP	5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7LBM 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9EHZ 9EI1 9EI3 9EI4 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression	RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-templated Transcription DNA-directed RNA Polymerase Activity Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Nucleoplasm RNA Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA Binding Nucleus Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process 5'-3' RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process RNA Polymerase I Complex RNA Polymerase III Complex Nucleotidyltransferase Activity Positive Regulation Of Organelle Assembly Nucleolus Positive Regulation Of Autophagosome Assembly Positive Regulation Of Vacuole Organization NF-kappaB Binding Identical Protein Binding Purine Ribonucleoside Triphosphate Binding
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