WWP2 and FBXL18

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		WWP2	FBXL18
Gene Name		WW domain containing E3 ubiquitin protein ligase 2	F-box and leucine-rich repeat protein 18
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ligase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways
Drugs
Diseases
GWAS		IgE levels ( 23146381)
Protein-Protein Interactions		53 interactors: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 PAIP1 PDLIM7 POLR2A POU5F1 RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SF1 SFTPC SMAD3 SMAD7 SNRPC SPG20 TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1	21 interactors: CALCOCO2 FHL3 GOLGA2 HNRNPK KRT40 KRTAP10-3 KRTAP4-12 MDFI MID2 MTUS2 NOTCH2NL PLSCR1 PNMA1 PSMA3 PSTPIP1 RBPMS TFCP2 TRAF1 TRAF4 WWP1 WWP2
Entrez ID		11060	80028
HPRD ID		03812	07753
Ensembl ID		ENSG00000198373	ENSG00000155034
Uniprot IDs		B4DHF6 O00308	F5H4Z4 Q96ME1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Excretion Response To Organic Substance DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Sodium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Positive Regulation Of Ossification Regulation Of Ossification RNA Biosynthetic Process Regulation Of Protein Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cellular Protein Metabolic Process Viral Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Catabolic Process RNA Processing Multicellular Organismal Water Homeostasis Programmed Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway	Viral Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Nitrogen Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Binding Proteasomal Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Viral Process Positive Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Defense Response Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Negative Regulation Of Binding Response To Stimulus Interaction With Host Immune System Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of JNK Cascade Positive Regulation Of Protein Modification Process Inflammatory Response Regulation Of Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Apoptotic Process Phosphatidylserine Biosynthetic Process Regulation Of Metabolic Process Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Binding Modification-dependent Protein Catabolic Process Regulation Of Viral Process Cell Death Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Protein Localization To Microtubule Death Regulation Of JNK Cascade Regulation Of Cellular Process Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination
Tagcloud (Difference) ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination
Tagcloud (Intersection) ?