TP53BP2 and YOD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TP53BP2	YOD1
Description		tumor protein p53 binding protein 2	YOD1 deubiquitinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol
	Molecular Function	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis	Proteolysis Response To Unfolded Protein Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination ERAD Pathway Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)	Systolic blood pressure ( 28234671)
Interacting Genes		119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575	30 interacting genes: ATG14 BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 ZFP57
Entrez ID		7159	55432
HPRD ID		11803	10312
Ensembl ID		ENSG00000143514	ENSG00000180667
Uniprot IDs		Q13625	Q5VVQ6
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP	4BOQ 4BOS 4BOZ
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein-containing Complex Protein K48-linked Ubiquitination Zinc Ion Binding Cytoplasm Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coactivator Activity Identical Protein Binding Proteolysis Proteolysis Involved In Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Positive Regulation Of Signal Transduction Nucleus Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Nuclear Body Positive Regulation Of Protein Modification Process Regulation Of Defense Response Transferase Activity Negative Regulation Of Necroptotic Process Response To Other Organism Regulation Of RIG-I Signaling Pathway Negative Regulation Of Programmed Necrotic Cell Death Protein Catabolic Process Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process
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