WWP2 and DIDO1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)

		WWP2	DIDO1
Gene Name		WW domain containing E3 ubiquitin protein ligase 2	death inducer-obliterator 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Spindle
	Molecular Function	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ligase Activity	Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Transcription, DNA-templated Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		IgE levels ( 23146381)
Protein-Protein Interactions		53 interactors: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 PAIP1 PDLIM7 POLR2A POU5F1 RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SF1 SFTPC SMAD3 SMAD7 SNRPC SPG20 TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1	9 interactors: APP ARAF DVL3 HIST3H3 HNRNPK KCNK4 SRSF1 WWP1 WWP2
Entrez ID		11060	11083
HPRD ID		03812	10363
Ensembl ID		ENSG00000198373	ENSG00000101191
Uniprot IDs		B4DHF6 O00308	Q9BTC0
PDB IDs			2M3H 4L7X
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Excretion Response To Organic Substance DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Sodium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Positive Regulation Of Ossification Regulation Of Ossification RNA Biosynthetic Process Regulation Of Protein Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cellular Protein Metabolic Process Viral Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Catabolic Process RNA Processing Multicellular Organismal Water Homeostasis Programmed Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway	Viral Entry Into Host Cell Entry Into Host Cell Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process MRNA 3'-end Processing MRNA Processing Regulation Of Protein Metabolic Process Interaction With Host RNA 3'-end Processing Positive Regulation Of Protein Metabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction MRNA Metabolic Process Viral Process RNA Processing Collateral Sprouting In Absence Of Injury Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Non-canonical Wnt Signaling Pathway Via JNK Cascade MRNA 5'-splice Site Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Viral Life Cycle Axon Choice Point Recognition Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Neuron Remodeling Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Translation Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Regulation Of Metabolic Process Outflow Tract Septum Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Receptor Biosynthetic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Cellular Protein Metabolic Process Cellular Copper Ion Homeostasis RNA Splicing
Tagcloud ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination	20q 20q11 abnormality amplification arm band breakpoints chromosome consistently del deleted distal explain favourable hck hybridization ider interstitial isochromosome material myelodysplastic possibly proximal regions retained tnfrsf6b tumour variable variant
Tagcloud (Difference) ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination	20q 20q11 abnormality amplification arm band breakpoints chromosome consistently del distal explain favourable hck hybridization ider interstitial isochromosome material myelodysplastic possibly proximal regions retained tnfrsf6b tumour variable variant
Tagcloud (Intersection) ?		deleted