TP53BP2 and PPHLN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TP53BP2	PPHLN1
Description		tumor protein p53 binding protein 2	periphilin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding	RNA Binding Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis	Keratinization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Protein Localization To Heterochromatin Constitutive Heterochromatin Formation
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)	Body size at age 10 ( 32376654) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575	27 interacting genes: APP BCL2L1 CASP5 CCDC57 CDC37 CDK6 CLK1 FBXO7 FXR1 ITGB1BP2 MTUS2 NAGK OGT PAXIP1 PPL SEPTIN8 SHANK3 SNCAIP SQSTM1 SRPK2 TGM2 TOMM20 TOPBP1 TP53BP2 TSGA10 UFD1 VIM
Entrez ID		7159	51535
HPRD ID		11803	10488
Ensembl ID		ENSG00000143514	ENSG00000134283
Uniprot IDs		Q13625	F8W6A0 Q8NEY8
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP	6SWG
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression	Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cytoplasm Regulation Of Cell Cycle Regulation Of Neuron Apoptotic Process Intracellular Membraneless Organelle Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Cytosol Glial Cell Development Scaffold Protein Binding Autophagy Of Mitochondrion Regulation Of Defense Response Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Programmed Cell Death Cytoskeleton Protein Targeting Apoptotic Process Cellular Response To Catecholamine Stimulus Astrocyte Development Presynapse Programmed Cell Death Response To Catecholamine Synapse Response To Muramyl Dipeptide Regulation Of Innate Immune Response Positive Regulation Of Mitophagy SH3 Domain Binding Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Synaptic Transmission Protein Binding Developmental Process Regulation Of Mitotic Cell Cycle Organelle Organization
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