WWP2 and RUSC1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		WWP2	RUSC1
Gene Name		WW domain containing E3 ubiquitin protein ligase 2	RUN and SH3 domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Early Endosome Golgi Apparatus Microtubule Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Cell Junction Cytoplasmic Vesicle Postsynaptic Membrane
	Molecular Function	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ligase Activity	Actin Binding SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Protein Polyubiquitination Positive Regulation Of Signal Transduction
Pathways
Drugs
Diseases
GWAS		IgE levels ( 23146381)
Protein-Protein Interactions		53 interactors: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 PAIP1 PDLIM7 POLR2A POU5F1 RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SF1 SFTPC SMAD3 SMAD7 SNRPC SPG20 TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1	7 interactors: APP FAM9B NTRK1 PNMA1 RBPMS STUB1 WWP2
Entrez ID		11060	23623
HPRD ID		03812	10206
Ensembl ID		ENSG00000198373	ENSG00000160753
Uniprot IDs		B4DHF6 O00308	B3KWM9 B4DQB8 Q5T9V0 Q9BVN2
PDB IDs			4GIW
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Excretion Response To Organic Substance DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Sodium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Positive Regulation Of Ossification Regulation Of Ossification RNA Biosynthetic Process Regulation Of Protein Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cellular Protein Metabolic Process Viral Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Catabolic Process RNA Processing Multicellular Organismal Water Homeostasis Programmed Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway	Protein K63-linked Ubiquitination Protein Autoubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Synaptic Growth At Neuromuscular Junction Regulation Of Protein Binding Regulation Of Cellular Protein Metabolic Process Collateral Sprouting In Absence Of Injury Protein Polyubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axonogenesis Involved In Innervation Axon Choice Point Recognition Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Protein Phosphorylation Proteasomal Protein Catabolic Process Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Learning Or Memory Olfactory Nerve Development Cellular Response To Nicotine Cognition Positive Regulation Of Proteolysis Neuron Remodeling Regulation Of Signal Transduction Response To Hydrostatic Pressure Locomotion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Phosphorylation Regulation Of Glucocorticoid Metabolic Process Nerve Growth Factor Signaling Pathway Regulation Of Signaling Positive Regulation Of SMAD Protein Import Into Nucleus Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Axon Guidance Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Response To Misfolded Protein Cellular Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Catalytic Activity Cellular Copper Ion Homeostasis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Metabolic Process
Tagcloud ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination
Tagcloud (Difference) ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination
Tagcloud (Intersection) ?