WWP2 and SCAMP3

Number of citations of the paper that reports this interaction (PMID 19158374)
15

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WWP2	SCAMP3
Gene Name		WW domain containing E3 ubiquitin protein ligase 2	secretory carrier membrane protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Membrane Extracellular Vesicular Exosome	Golgi Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ligase Activity	Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Post-Golgi Vesicle-mediated Transport Protein Transport Response To Retinoic Acid
Pathways
Drugs
Diseases
GWAS		IgE levels ( 23146381)	Crohn's disease ( 21102463)
Protein-Protein Interactions		53 interactors: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 PAIP1 PDLIM7 POLR2A POU5F1 RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SF1 SFTPC SMAD3 SMAD7 SNRPC SPG20 TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1	8 interactors: APP EGFR HGS NEDD4 NEDD4L TSG101 WWP2 YAP1
Entrez ID		11060	10067
HPRD ID		03812	06074
Ensembl ID		ENSG00000198373	ENSG00000116521
Uniprot IDs		B4DHF6 O00308	O14828
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Excretion Response To Organic Substance DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Sodium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Positive Regulation Of Ossification Regulation Of Ossification RNA Biosynthetic Process Regulation Of Protein Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cellular Protein Metabolic Process Viral Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Catabolic Process RNA Processing Multicellular Organismal Water Homeostasis Programmed Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Gene Expression Regulation Of Protein Catabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Sodium Ion Transport Regulation Of Transcription From RNA Polymerase II Promoter Protein Targeting To Lysosome Regulation Of Cellular Localization Response To Radiation Protein Localization To Lysosome Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transmembrane Transporter Activity Negative Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Signaling Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Polyubiquitination Cellular Protein Catabolic Process Protein Targeting To Vacuole Viral Life Cycle Negative Regulation Of Biosynthetic Process Protein Catabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Transcription, DNA-templated Skin Development Protein K63-linked Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Epidermis Development Negative Regulation Of Transporter Activity Protein Monoubiquitination Regulation Of Membrane Potential Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination	associate associates carrier compartments coordinately depletions endosomal endosomes escrt escrts hect immunoelectron ligases localizes lysines motifs multimonoubiquitylated multivesicular mvbs prelysosomal psap py recycling sorting sustain tsg101 ubiquitylatable ubiquitylation unless
Tagcloud (Difference) ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination	associate associates carrier compartments coordinately depletions endosomal endosomes escrt escrts hect immunoelectron localizes lysines motifs multimonoubiquitylated multivesicular mvbs prelysosomal psap py recycling sorting sustain tsg101 ubiquitylatable ubiquitylation unless
Tagcloud (Intersection) ?		ligases