WWP2 and SCN5A

Number of citations of the paper that reports this interaction (PMID 15548568)
20

Data Source:
BioGRID (pull down)

		WWP2	SCN5A
Gene Name		WW domain containing E3 ubiquitin protein ligase 2	sodium channel, voltage gated, type V alpha subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Membrane Extracellular Vesicular Exosome	Voltage-gated Sodium Channel Complex Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Integral Component Of Membrane Lateral Plasma Membrane T-tubule Sarcolemma
	Molecular Function	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ligase Activity	Voltage-gated Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Ion Channel Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Regulation Of Heart Rate Cardiac Ventricle Development Brainstem Development Sodium Ion Transport Axon Guidance Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Neuronal Action Potential Telencephalon Development Cerebellum Development Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Bundle Of His Cell To Purkinje Myocyte Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transport
Pathways			Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs			Indecainide Ranolazine Phenytoin Disopyramide Lidocaine Mexiletine Hexylcaine Dibucaine Mephenytoin Carbamazepine Verapamil Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine
Diseases
GWAS		IgE levels ( 23146381)	Electrocardiographic conduction measures ( 23463857 19389651) Electrocardiographic traits ( 20062063) PR interval ( 20062060 23139255 21347284) QT interval ( 19305408 19305409) Ventricular conduction ( 21076409)
Protein-Protein Interactions		53 interactors: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 PAIP1 PDLIM7 POLR2A POU5F1 RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SF1 SFTPC SMAD3 SMAD7 SNRPC SPG20 TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1	17 interactors: CALM1 CBL CDK2 DLG1 DLG2 DLG3 DLG4 INADL NEDD4 NEDD4L RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 WWP2
Entrez ID		11060	6331
HPRD ID		03812	02543
Ensembl ID		ENSG00000198373	ENSG00000183873
Uniprot IDs		B4DHF6 O00308	E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90
PDB IDs			2KBI 2L53 4DCK 4DJC
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Excretion Response To Organic Substance DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Sodium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Positive Regulation Of Ossification Regulation Of Ossification RNA Biosynthetic Process Regulation Of Protein Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cellular Protein Metabolic Process Viral Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Catabolic Process RNA Processing Multicellular Organismal Water Homeostasis Programmed Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway	Receptor Localization To Synapse Protein Localization To Synapse Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Receptor Clustering Nucleotide Phosphorylation Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Muscle System Process Regulation Of Potassium Ion Transmembrane Transporter Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Sodium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Regulation Of Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Muscle Contraction Negative Regulation Of Sodium Ion Transport Synaptic Transmission Regulation Of Protein Metabolic Process Negative Regulation Of Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Catalytic Activity Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Signaling Protein Localization To Membrane Regulation Of Dephosphorylation Positive Regulation Of Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Membrane Repolarization Cortical Actin Cytoskeleton Organization Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Signal Transduction Cortical Cytoskeleton Organization Membrane Organization Protein Polyubiquitination Synapse Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein K63-linked Ubiquitination
Tagcloud ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination	abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge
Tagcloud (Difference) ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination	abbreviated abbreviating apd90 arrhythmogenesis arterially atx bifurcated dispersion endocardial epicardial extrastimuli herg lqt2 lqt3 lqts mexiletine pacing pointes prolongation purkinje qt repolarization sotalol steeper tdr torsade totally transmural wedge
Tagcloud (Intersection) ?