TP53BP2 and H2BC4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TP53BP2	H2BC4
Description		tumor protein p53 binding protein 2	H2B clustered histone 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome
	Molecular Function	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs			Copper
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)	Skin and soft tissue infections ( 33662382)
Interacting Genes		119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575	6 interacting genes: AP2M1 ESR1 HPF1 PARP1 PARP2 TP53BP2
Entrez ID		7159	8347
HPRD ID		11803	13656
Ensembl ID		ENSG00000143514	ENSG00000180596
Uniprot IDs		Q13625	B2R4S9 P62807
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP	5GT0 5KGF 6ACO 6C0W 6FML 6R0C 6RNY 6SE0 6SE6 6SEE 6SEF 6SEG 6UPK 6UPL 6X59 6X5A 6XJD 7A08 7JO9 7JOA 7PII 7R5R 7TAN 7TRF 7U46 7U47 7U4D 7U50 7U51 7U52 7U53 7UV9 7Y8R 7YWX 7YYH 8ATF 8AV6 8JBX 8OFF 8OO7 8OOA 8OOP 8OOS 8OX0 8OX1 8QZM 8TXV 8TXW 8TXX 8U13 8VWS 8VWT 8VWU 8VWV 8X15 8X19 8X1C 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9EOZ
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression	Protein Localization To Chromatin Protein Localization To Chromosome Protein Poly-ADP-ribosylation DNA Repair-dependent Chromatin Remodeling NAD+-protein-serine ADP-ribosyltransferase Activity DNA ADP-ribosylation Site Of DNA Damage NAD DNA ADP-ribosyltransferase Activity Poly-ADP-D-ribose Binding Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Chromatin Binding NAD+-protein Mono-ADP-ribosyltransferase Activity Decidualization Protein Localization To Organelle Chromatin Remodeling NAD+ Poly-ADP-ribosyltransferase Activity DNA Modification Double-strand Break Repair Nucleosome Binding Positive Regulation Of Cardiac Muscle Hypertrophy Intracellular Protein Localization Nuclear Estrogen Receptor Binding Chromatin Organization Damaged DNA Binding Regulation Of Cardiac Muscle Hypertrophy NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Nucleotidyltransferase Activity DNA Repair Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of ATP Biosynthetic Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Hippocampal Neuron Apoptotic Process Chromosome Regulation Of Base-excision Repair ATP Generation From Poly-ADP-D-ribose Signal Sequence Binding Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Protein ADP-ribosyltransferase-substrate Adaptor Activity DNA Metabolic Process Transcription Pausing By RNA Polymerase II
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