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TP53BP2 and CEP55
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
TP53BP2
CEP55
Description
tumor protein p53 binding protein 2
centrosomal protein 55
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Cytoplasm
Centrosome
Centriole
Cytoskeleton
Membrane
Midbody
Cleavage Furrow
Intercellular Bridge
Flemming Body
Molecular Function
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
NF-kappaB Binding
Protein Binding
Identical Protein Binding
Biological Process
Apoptotic Process
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Mitotic Cytokinesis
Nucleus Organization
Mitotic Metaphase Chromosome Alignment
Establishment Of Protein Localization
Cell Division
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Midbody Abscission
Cranial Skeletal System Development
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Triptolide cytotoxicity (
26121980
)
High density lipoprotein cholesterol levels (
30498476
)
Metabolite levels (
23823483
)
Interacting Genes
119 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC92
CDC5L
CEP55
CEP95
CGN
CREBBP
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBC
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
94 interacting genes:
AIRIM
AKAP9
ANXA11
ARHGEF15
BAG4
C1orf216
CBY2
CCBE1
CCDC120
CCHCR1
CDC37
CDC45
CDK1
CDSN
CEP57L1
CFTR
COL8A1
CPSF7
DTNB
ECSIT
EIF1AD
ENKD1
ESS2
EXOSC5
FAM161B
FAM90A1
FBF1
FXR2
GOLGA2
GOLGA8DP
HAUS1
HGS
HNRNPA0
HSF2BP
KANK2
KIFC3
KRT31
LENG1
LGALS4
LRRC23
MAPK1
MAPK1IP1L
MFAP1
MIA3
MORF4L2
NDEL1
NEDD4L
NOS3
NTAQ1
NXF1
OGT
PCNT
PDCD6IP
PEF1
PIN1
PLEKHG6
PLK1
POLM
POM121
PPP1R16B
PRPF6
PSEN2
PSMC2
PTPN23
PWWP3A
RAB3D
RBM14
RBM17
RBM22
RBM42
RBPMS
RCOR3
RNF32
SDCBP
SF1
SFPQ
SNRPB
SNRPN
SNW1
SS18L1
SUPT5H
TCL1A
TEAD4
TEX11
TFG
TFIP11
TP53BP2
TSG101
UBC
VPS37C
VPS37D
WASHC1
WASHC3
ZNF48
Entrez ID
7159
55165
HPRD ID
11803
12569
Ensembl ID
ENSG00000143514
ENSG00000138180
Uniprot IDs
Q13625
Q53EZ4
PDB IDs
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
3E1R
3WUT
3WUU
3WUV
Enriched GO Terms of Interacting Partners
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Protein Binding
Cytosol
Cytoplasm
Regulation Of Protein Metabolic Process
Nucleus
Regulation Of Signal Transduction
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Protein Kinase Binding
Positive Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Signal Transduction
Regulation Of Signaling
Postsynaptic Cytosol
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Response To Radiation
Cytoskeleton
Regulation Of Protein Modification Process
Centrosome
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Nucleoplasm
Protein Modification Process
Protein Modification By Small Protein Conjugation
Regulation Of JNK Cascade
Plasma Membrane Bounded Cell Projection Organization
Identical Protein Binding
PTW/PP1 Phosphatase Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Entrainment Of Circadian Clock By Photoperiod
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Cell Projection Organization
Regulation Of Primary Metabolic Process
Protein Domain Specific Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Photoperiodism
Entrainment Of Circadian Clock
Channel Inhibitor Activity
NF-kappaB P50/p65 Complex
Regulation Of Neurogenesis
Regulation Of Post-translational Protein Modification
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Protein Binding
Spliceosomal Complex
Centrosome
MRNA Processing
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
RNA Splicing
Nucleoplasm
MRNA Metabolic Process
Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Catalytic Step 2 Spliceosome
Cytoskeleton
Multivesicular Body Assembly
Multivesicular Body Organization
Positive Regulation Of Exosomal Secretion
Late Endosome To Vacuole Transport
Organelle Organization
Regulation Of Exosomal Secretion
Regulation Of Extracellular Exosome Assembly
Endosome Transport Via Multivesicular Body Sorting Pathway
RNA Processing
Calcium-dependent Protein Binding
RNA Binding
Viral Budding Via Host ESCRT Complex
Multivesicular Body Sorting Pathway
Positive Regulation Of Exocytosis
Viral Budding
MRNA Binding
Protein Localization To Vacuole
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Cellular Component Assembly
Nucleic Acid Metabolic Process
Microtubule Nucleation
Cytosol
Establishment Of Protein Localization To Vacuole
ESCRT I Complex
Centriole
Cytoplasm
Spindle
Nucleic Acid Binding
U4/U6 X U5 Tri-snRNP Complex
Microtubule Cytoskeleton Organization Involved In Mitosis
MRNA Cis Splicing, Via Spliceosome
SnRNP Binding
Endosome Organization
Microtubule Organizing Center Organization
Membrane Fission
Microtubule-based Process
Organelle Assembly
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Tagcloud (Difference)
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Tagcloud (Intersection)
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