TP53BP2 and BCAS2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TP53BP2	BCAS2
Name		tumor protein p53 binding protein 2	BCAS2 pre-mRNA processing factor
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Centrosome Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding	Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Ovarian Follicle Development MRNA Processing RNA Splicing Protein Catabolic Process Oogenesis Oocyte Development Spindle Assembly
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	mRNA Splicing - Major Pathway
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Triptolide cytotoxicity ( 26121980 )	Autism ( 24189344 ) Chronotype ( 30696823 )
Novel Interactors		2 novel interactors: DISC1 HYOU1	None recorded
Interacting Genes		119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575	82 interacting genes: ACY1 AIMP2 ANKHD1 BLK CCDC120 CCDC17 CNOT4 CPSF7 DMRTB1 DUT ECM1 EIF4ENIF1 EMILIN3 ENKD1 EP300 ESR1 ESR2 FAM86C1P FHIT GOLGA2 HGS HNRNPLL HSF2BP IFI35 IKZF3 KRT20 KRT27 KRT31 KRT34 KRT35 KRT36 KRT37 KRT75 KRTAP19-6 KRTAP8-1 LARP4 LMO1 LMO2 LMO3 LMO4 MBNL1 MED29 MIIP MYOZ3 NIP7 OIP5 PAX5 PCBD2 PFDN5 PGR PLAGL2 PLEKHF2 POT1 PPARG PRRC2B QKI RBM22 RBPMS RPL5 SAXO4 SF1 SLAIN1 SMARCD1 SNRNP200 SNRPC SNW1 SPMIP5 SPMIP6 TCF4 TCHP TFIP11 TP53BP2 TRAF1 TRNAU1AP TXN2 TXNRD2 UBC USHBP1 WDR83 YPEL3 ZMAT5 ZWINT
Entrez ID		7159	10286
HPRD ID		11803	05777
Ensembl ID		ENSG00000143514	ENSG00000116752
Uniprot IDs		Q13625	B2R7W3 O75934
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP	5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
GO Terms Enriched among Interactors		Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression	Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Nucleic Acid Binding MRNA Metabolic Process MRNA Processing Structural Molecule Activity Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Estrogen Response Element Binding RNA Binding RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding RNA Processing Catalytic Step 2 Spliceosome Nucleus Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nuclear Receptor Activity Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Epithelial Cell Differentiation Nuclear Steroid Receptor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Morphogenesis Of An Epithelium MRNA Binding DNA-binding Transcription Factor Binding Regulation Of RNA Splicing Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Protein-containing Complex Organization Steroid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cell Differentiation Supramolecular Fiber Organization Hormone-mediated Signaling Pathway Tissue Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization