WWP2 and NDFIP2

Number of citations of the paper that reports this interaction (PMID 15252135)
19

Data Source:
HPRD (in vitro)

		WWP2	NDFIP2
Gene Name		WW domain containing E3 ubiquitin protein ligase 2	Nedd4 family interacting protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Membrane Extracellular Vesicular Exosome	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ligase Activity	Signal Transducer Activity Protein Binding WW Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Transport
Pathways
Drugs
Diseases
GWAS		IgE levels ( 23146381)	Major depressive disorder ( 23377640) Pancreatic cancer ( 20686608)
Protein-Protein Interactions		53 interactors: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 PAIP1 PDLIM7 POLR2A POU5F1 RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SF1 SFTPC SMAD3 SMAD7 SNRPC SPG20 TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1	6 interactors: ITCH LYN NEDD4 NEDD4L SMURF1 WWP2
Entrez ID		11060	54602
HPRD ID		03812	17629
Ensembl ID		ENSG00000198373	ENSG00000102471
Uniprot IDs		B4DHF6 O00308	B4DGY6 Q9NV92
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Excretion Response To Organic Substance DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Sodium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Positive Regulation Of Ossification Regulation Of Ossification RNA Biosynthetic Process Regulation Of Protein Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cellular Protein Metabolic Process Viral Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Catabolic Process RNA Processing Multicellular Organismal Water Homeostasis Programmed Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Cellular Macromolecule Catabolic Process Negative Regulation Of Signal Transduction Interaction With Host Negative Regulation Of Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Sodium Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Proteolysis Cellular Protein Modification Process Regulation Of Ion Transport Regulation Of Cellular Response To Growth Factor Stimulus Receptor Catabolic Process Viral Life Cycle Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Catabolic Process Positive Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Membrane Potential Negative Regulation Of Cellular Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Transporter Activity Cellular Protein Metabolic Process Protein Monoubiquitination Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transport Positive Regulation Of Protein Metabolic Process Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Locomotion Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination	believe colocalized demonstrating exploits expresses herpes hsv interacted interactins itch ligase lysosome modifies motifs nedd4 py similarity simplex striking subcellular tegument ubiquitin ul56 virions vp16 vp5 warrant
Tagcloud (Difference) ?		accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligases malignancies member neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination	believe colocalized demonstrating exploits expresses herpes hsv interacted interactins itch lysosome modifies motifs py similarity simplex striking subcellular tegument ubiquitin ul56 virions vp16 vp5 warrant
Tagcloud (Intersection) ?		ligase nedd4