TP53BP2 and PLK1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TP53BP2	PLK1
Description		tumor protein p53 binding protein 2	polo like kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Chromatin Synaptonemal Complex Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Spindle Microtubule Microtubule Cytoskeleton Midbody Centriolar Satellite Spindle Midzone Mitotic Spindle Pole
	Molecular Function	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Mitotic Cytokinesis Double-strand Break Repair Via Homologous Recombination Microtubule Bundle Formation Double-strand Break Repair Protein Phosphorylation Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Chromosome Condensation Mitotic Nuclear Membrane Disassembly Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Female Meiosis Chromosome Segregation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Protein Localization To Organelle Negative Regulation Of Apoptotic Process Homologous Chromosome Segregation Establishment Of Protein Localization Positive Regulation Of Proteolysis Golgi Inheritance Nuclear Membrane Disassembly Centrosome Separation Cell Division Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Synaptonemal Complex Disassembly Protein Localization To Chromatin Protein Localization To Centrosome Protein Localization To Nuclear Envelope Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Localization To Cell Cortex Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase Mitotic Metaphase/Anaphase Transition Mitotic Telophase/Cytokinesis Cyclin A/B1/B2 associated events during G2/M transition The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs			3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea Wortmannin Fostamatinib Volasertib
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)	Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575	147 interacting genes: - ACTL6B AKAP12 APP ASPM BAG6 BCL2L1 BIRC6 BRCA2 BUB1 C6orf136 CBL CCNB1 CDC14A CDC25C CDC6 CEBPA CENPQ CENPU CEP55 CHEK2 CSN1S1 CSN2 CTNNB1 CUL4B DNAJB9 DNHD1 ECT2 EIF6 ERCC6L EYA1 EYA4 FBXL5 FBXW7 GET4 GLB1 GORASP1 HNRNPU IDH1 IDH2 IKBKB INTS11 ITSN1 KIF23 KIF2C KLF4 KLHL22 KRABD3 LMO4 LRP5L LRRK1 LRRK2 MAD2L1BP MAGED1 MCM2 MCM3 MCM7 MDM2 MISP MPP2 MYC MYT1 NCAPD3 NCAPG2 NCAPH2 NEDD1 NEDD4 NHSL2 NINL NPM1 NUDC PARP10 PHC2 PIN1 PITPNM1 PKMYT1 PON1 PPID PPIL2 PPP1R12A PPP6R2 PRC1 PRKN PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSRC1 PTEN PTPRD RAB1A RABAC1 RACGAP1 RAD51 RAP1GAP RECQL5 RELA REST RGCC RICTOR RNF126 RNF2 RSF1 RXRA SEPTIN9 SHCBP1 SIMC1 SNCA SNCB SPOUT1 SREBF1 STAG2 STUB1 SUGT1 TIMELESS TNFSF11 TOP2A TP53 TP53BP2 TP73 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 UBE2I UHRF1 USP16 USP7 VIM VMA22 VRK2 VRK3 WAC WEE1 ZNF71
Entrez ID		7159	5347
HPRD ID		11803	03652
Ensembl ID		ENSG00000143514	ENSG00000166851
Uniprot IDs		Q13625	P53350
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP	1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53 4LKL 4LKM 4O56 4O6W 4O9W 4RCP 4WHH 4WHK 4WHL 4X9R 4X9V 4X9W 5J19 5NEI 5NFU 5NJE 5NMM 5NN1 5NN2 5TA6 5TA8 6AX4 6GY2 7MSO 7MX1 8BJT 8CRC 8JOQ 8JOY 8S30 8S31 8WFP 8X72 8XB9
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression	Proteasome Core Complex Cell Division Cytoplasm Regulation Of Cell Cycle Nucleoplasm Regulation Of Cell Cycle Process Nucleus Cytosol Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteasome Complex Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Macromolecule Catabolic Process Positive Regulation Of Cell Cycle Proteasome Core Complex, Beta-subunit Complex Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Spindle Regulation Of Cell Cycle Phase Transition Proteasome Core Complex, Alpha-subunit Complex Regulation Of Cellular Response To Stress Microtubule-based Process Organelle Organization Centrosome Cytoskeleton Microtubule Cytoskeleton Organization Midbody Proteolysis Regulation Of Intracellular Signal Transduction Cellular Response To Radiation DNA Repair Chromosome Segregation Regulation Of Chromosome Organization Regulation Of Cytokinesis Macromolecule Metabolic Process Response To Xenobiotic Stimulus Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Chromosome Segregation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Cycle Positive Regulation Of Programmed Cell Death Protein Kinase Binding Chromosome Regulation Of Chromosome Segregation
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