WWP2 and MIR19B1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		WWP2	MIR19B1
Description		WW domain containing E3 ubiquitin protein ligase 2	microRNA 19b-1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Extracellular Space RISC Complex Perinuclear Region Of Cytoplasm Blood Microparticle Extracellular Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Transferase Activity Potassium Channel Inhibitor Activity Transmembrane Transporter Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity Transcription Regulator Inhibitor Activity	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transport Protein Modification Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Fibroblast Migration Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Cholesterol Homeostasis Negative Regulation Of Coagulation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Fate Commitment Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Bacterial Lipopeptide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cholesterol Efflux Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Reverse Cholesterol Transport Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Apoptotic Process Involved In Development Negative Regulation Of Apolipoprotein A-I-mediated Signaling Pathway
Pathways		Regulation of PTEN stability and activity RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 31562340 28552196) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Myocardial infarction ( 33532862) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 33082346) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)
Interacting Genes		115 interacting genes: ANKRD44 ARRDC3 ATN1 ATOSB ATXN3 C3orf70 CALCOCO2 CDC34 CFAP36 CFTR CLCN5 CPSF6 DAG1 DIDO1 DVL2 EFCAB3 EGR2 ENTREP1 EWSR1 FAF1 FAM131B FAM131C FBXL18 FUT3 GADD45GIP1 GAS2L2 GGN GRAP2 HGS HNRNPUL1 IFIT2 IL2RG IL6R IST1 KHDRBS3 LGALS9B MED25 MED4 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 NHERF2 OPTN PAIP1 PATZ1 PDCD6IP PDLIM7 PRKAA2 PSMD4 PSMF1 PTEN RABEP2 RAD23A RAD23B RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFMBT1 SFTPC SMAD3 SMAD7 SMR3A SNRPB SNRPC SOX2 SPART SQSTM1 STAM TFAP2A THBS1 TICAM1 TNK2 TOM1 TOM1L2 TP53BP2 TRAF4 TRIP10 UBAC1 UBAP1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBL7 UBQLN1 UBQLN4 UBTD1 USP5 USP7 VASP VPS37C WASF2 WBP1 WBP2 WDR5 WIPF1 ZNF688	103 interacting genes: AIMP1 AIMP2 APOBEC3B AQR C1QBP CELF1 CELF2 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 P3H1 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBBP6 RBFOX2 RBM12B RBM14 RBM4 RBMS2 RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 WDR33 WWP1 WWP2 YBX1 YBX2 YBX3 ZNF346 ZNF385A
Entrez ID		11060	406980
HPRD ID		03812
Ensembl ID		ENSG00000198373	ENSG00000284375
Uniprot IDs		B4DHF6 O00308
PDB IDs		4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS 8EI5 8EI6 8EI7 8EI8 9EQH
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis WW Domain Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Ubiquitin Binding Protein Polyubiquitination Protein Modification By Small Protein Conjugation Endosome Catabolic Process Nucleoplasm Protein Ubiquitination Cytosol Post-translational Protein Modification Protein K48-linked Ubiquitination Multivesicular Body Assembly Multivesicular Body Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Sensory Perception Of Salty Taste Regulation Of Proteasomal Protein Catabolic Process Endosome Organization Macroautophagy Regulation Of Proteolysis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Perinuclear Region Of Cytoplasm Proteasome Binding Autophagy Protein K11-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Aldosterone Sodium Channel Complex Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleus Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Post-transcriptional Regulation Of Gene Expression MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA 3'-UTR Binding Spliceosomal Complex Regulation Of MRNA Processing Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation Cytoplasmic Stress Granule MiRNA Binding Negative Regulation Of MRNA Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity RNA 3'-end Processing TRNA Aminoacylation Negative Regulation Of Translation Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Metabolic Process Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of RNA Stability Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process Regulation Of MRNA Stability MRNA Stabilization Negative Regulation Of Macromolecule Metabolic Process Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation
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