WWP2 and THBS1

Number of citations of the paper that reports this interaction (PubMedID 35331737)
83

Data Source:
BioGRID (enzymatic study)

		WWP2	THBS1
Description		WW domain containing E3 ubiquitin protein ligase 2	thrombospondin 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Transferase Activity Potassium Channel Inhibitor Activity Transmembrane Transporter Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity Transcription Regulator Inhibitor Activity	Phosphatidylserine Binding Fibronectin Binding Protease Binding Endopeptidase Inhibitor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Protein Homodimerization Activity Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Fibrinogen Binding Collagen V Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transport Protein Modification Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Angiogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Immune System Process Apoptotic Process Inflammatory Response Immune Response Response To Unfolded Protein Cell Adhesion Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation of PTEN stability and activity RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus	Platelet degranulation Signaling by PDGF Integrin cell surface interactions Syndecan interactions Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 31562340 28552196) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Myocardial infarction ( 33532862) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 33082346) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)	Cortical volume ( 32963231) Liver enzyme levels (alanine transaminase) ( 33972514) Logical memory (immediate recall) in normal cognition ( 29274321) Urate levels ( 31578528)
Interacting Genes		115 interacting genes: ANKRD44 ARRDC3 ATN1 ATOSB ATXN3 C3orf70 CALCOCO2 CDC34 CFAP36 CFTR CLCN5 CPSF6 DAG1 DIDO1 DVL2 EFCAB3 EGR2 ENTREP1 EWSR1 FAF1 FAM131B FAM131C FBXL18 FUT3 GADD45GIP1 GAS2L2 GGN GRAP2 HGS HNRNPUL1 IFIT2 IL2RG IL6R IST1 KHDRBS3 LGALS9B MED25 MED4 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 NHERF2 OPTN PAIP1 PATZ1 PDCD6IP PDLIM7 PRKAA2 PSMD4 PSMF1 PTEN RABEP2 RAD23A RAD23B RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFMBT1 SFTPC SMAD3 SMAD7 SMR3A SNRPB SNRPC SOX2 SPART SQSTM1 STAM TFAP2A THBS1 TICAM1 TNK2 TOM1 TOM1L2 TP53BP2 TRAF4 TRIP10 UBAC1 UBAP1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBL7 UBQLN1 UBQLN4 UBTD1 USP5 USP7 VASP VPS37C WASF2 WBP1 WBP2 WDR5 WIPF1 ZNF688	52 interacting genes: APP BGN CALCR CALR CD36 CD47 CFH COL11A1 COL18A1 COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL7A1 CORO1A CTSG DCN DHFR DYRK1A ELANE F2 FBN2 FGA FGF2 FN1 HRG HSP90AA1 IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 MTDH PDGFB PLG PLSCR1 SCARB2 SPARC TFPI TGFB1 TGM2 TNFAIP6 TNFRSF11B WEE2-AS1 WWP2
Entrez ID		11060	7057
HPRD ID		03812	01765
Ensembl ID		ENSG00000198373	ENSG00000137801
Uniprot IDs		B4DHF6 O00308	P07996
PDB IDs		4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS 8EI5 8EI6 8EI7 8EI8 9EQH	1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B 5FOE 7YYK
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis WW Domain Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Ubiquitin Binding Protein Polyubiquitination Protein Modification By Small Protein Conjugation Endosome Catabolic Process Nucleoplasm Protein Ubiquitination Cytosol Post-translational Protein Modification Protein K48-linked Ubiquitination Multivesicular Body Assembly Multivesicular Body Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Sensory Perception Of Salty Taste Regulation Of Proteasomal Protein Catabolic Process Endosome Organization Macroautophagy Regulation Of Proteolysis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Perinuclear Region Of Cytoplasm Proteasome Binding Autophagy Protein K11-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Aldosterone Sodium Channel Complex Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process	Extracellular Matrix Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Platelet-derived Growth Factor Binding Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Collagen Trimer Regulation Of Signal Transduction Positive Regulation Of Cell Migration Basement Membrane Positive Regulation Of Cell Motility Endodermal Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Locomotion Fibrillar Collagen Trimer Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Heparin Binding Regulation Of Hemostasis Cell Surface Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Coagulation Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Wound Healing Animal Organ Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Coagulation Regulation Of Cell-substrate Adhesion Platelet Activation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Multicellular Organismal Process Hemostasis
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