TP53BP2 and OTUB2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TP53BP2	OTUB2
Gene Name		tumor protein p53 binding protein 2	OTU deubiquitinase, ubiquitin aldehyde binding 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding	Ubiquitin-specific Protease Activity
	Biological Process	Cell Cycle Signal Transduction Central Nervous System Development Heart Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Signal Transduction Response To Ionizing Radiation Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Proteolysis Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: APP ATPAF2 ATXN7 BAIAP2 BCL2 BCL2L1 CCDC92 CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 HIST1H2BC HNRNPUL1 KIF5A LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRKAB2 PRPF31 PTN RELA SIAH1 SIAH2 SSX2IP SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26	33 interactors: APP ARRDC3 CPSF6 FAM168A KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 UBC UBE2N USP21 USP28
Entrez ID		7159	78990
HPRD ID		11803	07620
Ensembl ID		ENSG00000143514	ENSG00000089723
Uniprot IDs		Q13625	Q96DC9
PDB IDs		1YCS 2UWQ 4A63	1TFF 4FJV
Enriched GO Terms of Interacting Partners?		Neuron Death Neuron Apoptotic Process Response To Radiation Regulation Of Signal Transduction Regulation Of Signaling Response To External Stimulus Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Apoptotic Signaling Pathway Cell Part Morphogenesis Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Phosphorylation Response To Light Stimulus Protein Modification By Small Protein Conjugation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Cycle Neuron Projection Morphogenesis Regulation Of Mitochondrion Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Projection Morphogenesis Axonogenesis Cellular Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Protein Metabolic Process Response To Gamma Radiation Axon Development Regulation Of Extrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Generation Of Neurons Nervous System Development Cellular Response To Ionizing Radiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Innate Immune Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Neuron Projection Development Neurogenesis Anatomical Structure Morphogenesis	Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Viral Release From Host Cell Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Negative Regulation Of Viral Entry Into Host Cell Regulation Of Signal Transduction Protein Polyubiquitination Regulation Of Viral Entry Into Host Cell Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Cellular Protein Modification Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Cytokine Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Immune Response Defense Response Regulation Of Viral Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Locomotion Immune System Process I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interferon-gamma Signal Transduction Regulation Of Locomotion Response To Interferon-gamma Negative Regulation Of Viral Transcription Protein Metabolic Process Signaling Regulation Of Cellular Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Tagcloud ?		adenovirus angiotensin apoptosis array at2r bag3 bmp6 bmp7 bnipi cytokine downregulation du145 gadd45a hrk il6 il8 mapk microrna next numerous p44 pc r2 silence sirnas tnfsf10 trail transduced utilized	antiviral attenuation coimmunoprecipitations deubiquitinating deubiquitination e3 emerged enzymes ifn ifnb1 induction interacted interferon irf3 knockdown ligases negatively opposite otub1 regulate regulators regulatory traf3 traf6 translational triggered ubiquitin ubiquitination virus
Tagcloud (Difference) ?		adenovirus angiotensin apoptosis array at2r bag3 bmp6 bmp7 bnipi cytokine downregulation du145 gadd45a hrk il6 il8 mapk microrna next numerous p44 pc r2 silence sirnas tnfsf10 trail transduced utilized	antiviral attenuation coimmunoprecipitations deubiquitinating deubiquitination e3 emerged enzymes ifn ifnb1 induction interacted interferon irf3 knockdown ligases negatively opposite otub1 regulate regulators regulatory traf3 traf6 translational triggered ubiquitin ubiquitination virus
Tagcloud (Intersection) ?