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TP53BP2 and PPP1CA
Number of citations of the paper that reports this interaction (PubMedID
15231748
)
54
Data Source:
HPRD
(two hybrid)
TP53BP2
PPP1CA
Description
tumor protein p53 binding protein 2
protein phosphatase 1 catalytic subunit alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Protein Phosphatase Type 1 Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Glycogen Granule
Neuronal Cell Body
Dendritic Spine
Perikaryon
Extracellular Exosome
PTW/PP1 Phosphatase Complex
Presynapse
Postsynapse
Glutamatergic Synapse
Molecular Function
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
NF-kappaB Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Iron Ion Binding
Protein Binding
Protein Phosphatase 1 Binding
Hydrolase Activity
Phosphatase Activity
Ribonucleoprotein Complex Binding
Protein-containing Complex Binding
Metal Ion Binding
Transition Metal Ion Binding
Cadherin Binding Involved In Cell-cell Adhesion
RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
Biological Process
Apoptotic Process
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Telomere Maintenance
RNA Polymerase II Promoter Clearance
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Protein Dephosphorylation
Response To Lead Ion
Dephosphorylation
Lung Development
Circadian Regulation Of Gene Expression
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Telomere Maintenance In Response To DNA Damage
Regulation Of Translational Initiation In Response To Stress
Positive Regulation Of Glycogen Biosynthetic Process
Branching Morphogenesis Of An Epithelial Tube
Protein Stabilization
Cell Division
Regulation Of Canonical Wnt Signaling Pathway
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Cell-cell Adhesion
Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Triglyceride catabolism
DARPP-32 events
Downregulation of TGF-beta receptor signaling
Maturation of hRSV A proteins
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Triptolide cytotoxicity (
26121980
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
28552196
)
Interacting Genes
119 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC92
CDC5L
CEP55
CEP95
CGN
CREBBP
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBC
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
173 interacting genes:
AATK
AHCTF1
AKAP1
AKAP11
AKAP9
AKT1
APAF1
ASPM
AURKA
BAD
BAX
BCL2
BCL2L1
BCL2L2
BRCA1
BTBD10
C1QA
CAD
CAV1
CCDC181
CDC5L
CDCA2
CDH1
CEP126
CEP170
CEP192
CKB
CLCN2
CLOCK
CNP
CNST
CNTN1
CREB1
CRK
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CUL1
CXXC1
DCTN1
DCX
DEAF1
DELEC1
DYNLT4
EED
EIF2AK2
ESR1
FRMPD4
FXYD1
GLIPR1L2
GPKOW
H2AX
H3-3A
H3C1
HEYL
HSPA4
IBTK
ID2
ITGB8
JPH3
KANK1
KCNQ1
KCTD20
KIF13A
KIF18A
KNL1
LMTK2
LPIN2
MAFG
MAL2
MAP4K4
MAPK1
MAPK3
MAPT
MECOM
MIIP
MKI67
MPHOSPH10
MST1R
MYO16
NCAM1
NDP
NEDD8
NEK2
NOC2L
NOM1
NONO
NOP53
PAK1
PBK
PCDH7
PCNA
PHACTR1
PHACTR3
PHACTR4
PHB2
PHC1
PIAS1
PIAS3
PLCL2
POLR2A
PPP1R10
PPP1R11
PPP1R13B
PPP1R13L
PPP1R15A
PPP1R15B
PPP1R16A
PPP1R18
PPP1R1B
PPP1R2
PPP1R26
PPP1R27
PPP1R2B
PPP1R2C
PPP1R37
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R3E
PPP1R3G
PPP1R8
PPP1R9A
PPP1R9B
PPP2CA
PPP2R5C
PPP2R5E
PREX1
PRKCB
PRKCD
PRR16
PTEN
PTPN7
PYGM
RANBP9
RB1
RORC
RPRD2
RRP1B
SAXO4
SEH1L
SFI1
SFRP1
SH3RF2
SKP1
SLC45A1
SORL1
SPRED1
STAM
STAU1
SYTL2
TOE1
TOR1AIP1
TOX4
TP53
TP53BP2
TPRN
TRIM21
TSC2
TUSC3
UBC
UBE2Z
UBR5
ULK1
VDR
WBP11
WDR82
YLPM1
ZBTB11
ZFYVE16
ZFYVE9
ZNF827
Entrez ID
7159
5499
HPRD ID
11803
15942
Ensembl ID
ENSG00000143514
ENSG00000172531
Uniprot IDs
Q13625
A0A140VJS9
P62136
PDB IDs
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
3E7A
3E7B
3EGG
3EGH
3HVQ
3N5U
3V4Y
4G9J
4MOV
4MOY
4MP0
4XPN
5IOH
6ALZ
6CZO
6DCX
6DNO
6G0I
6G0J
6GHM
6OBN
6OBP
6OBQ
6OBR
6OBS
6OBU
6ZEE
6ZEF
6ZEG
6ZEH
6ZEI
6ZEJ
6ZK6
7QFB
7QM2
7T0Y
7TVF
7TXH
7UPI
8DWK
8DWL
8SW5
8SW6
8U5G
Enriched GO Terms of Interacting Partners
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Protein Binding
Cytosol
Cytoplasm
Regulation Of Protein Metabolic Process
Nucleus
Regulation Of Signal Transduction
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Protein Kinase Binding
Positive Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Signal Transduction
Regulation Of Signaling
Postsynaptic Cytosol
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Response To Radiation
Cytoskeleton
Regulation Of Protein Modification Process
Centrosome
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Nucleoplasm
Protein Modification Process
Protein Modification By Small Protein Conjugation
Regulation Of JNK Cascade
Plasma Membrane Bounded Cell Projection Organization
Identical Protein Binding
PTW/PP1 Phosphatase Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Entrainment Of Circadian Clock By Photoperiod
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Cell Projection Organization
Regulation Of Primary Metabolic Process
Protein Domain Specific Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Photoperiodism
Entrainment Of Circadian Clock
Channel Inhibitor Activity
NF-kappaB P50/p65 Complex
Regulation Of Neurogenesis
Regulation Of Post-translational Protein Modification
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Protein Phosphatase 1 Binding
Protein Phosphatase Inhibitor Activity
Phosphatase Binding
Intracellular Signal Transduction
Protein Phosphatase Regulator Activity
Protein Phosphatase Type 1 Complex
Negative Regulation Of Intracellular Signal Transduction
Apoptotic Process
Programmed Cell Death
Cell Death
Regulation Of Cell Cycle
Enzyme Binding
Regulation Of Intracellular Signal Transduction
Nucleoplasm
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Intrinsic Apoptotic Signaling Pathway
Nucleus
Glycogen Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Glycogen Binding
Regulation Of Cell Cycle Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Cytoplasm
Positive Regulation Of Metabolic Process
Polysaccharide Metabolic Process
Energy Reserve Metabolic Process
Cell Population Proliferation
Release Of Cytochrome C From Mitochondria
Chromosome
Response To Radiation
Apoptotic Signaling Pathway
Negative Regulation Of Metabolic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Programmed Cell Death
Response To Starvation
Regulation Of Glycogen Biosynthetic Process
Protein Localization To Organelle
Negative Regulation Of Apoptotic Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Protein Metabolic Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Response To Light Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Bcl-2 Family Protein Complex
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Tagcloud (Difference)
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Tagcloud (Intersection)
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