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C1QA and SGTA
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
C1QA
SGTA
Description
complement C1q A chain
small glutamine rich tetratricopeptide repeat co-chaperone alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Complement Component C1 Complex
Cell Surface
Extracellular Matrix
Synapse
Complement Component C1q Complex
Postsynapse
Extrinsic Component Of Presynaptic Membrane
Extrinsic Component Of Postsynaptic Membrane
Glutamatergic Synapse
Symbiont Cell Surface
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
TRC Complex
Molecular Function
Amyloid-beta Binding
Phosphatidylserine Binding
IgM Binding
Protein Binding
IgG Binding
Protein Binding
Identical Protein Binding
Molecular Adaptor Activity
BAT3 Complex Binding
Biological Process
Microglial Cell Activation
Immune System Process
Complement Activation
Complement Activation, Classical Pathway
Cell-cell Signaling
Neuron Remodeling
Innate Immune Response
Astrocyte Activation
Synapse Organization
Synapse Pruning
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
ERAD Pathway
Tail-anchored Membrane Protein Insertion Into ER Membrane
Negative Regulation Of ERAD Pathway
Positive Regulation Of ERAD Pathway
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Cetuximab
Etanercept
Palivizumab
Daclizumab
Bevacizumab
Diseases
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Interacting Genes
31 interacting genes:
APCS
BAG6
C1QB
C1QBP
C1QC
C1R
C1S
CD93
COL2A1
CR1
CRP
CSPG4
DCN
FN1
GNPNAT1
HIPK3
HMGB1
HRG
HSPB2
NLGN3
PIAS2
PPP1CA
PPP1CC
PTX3
SGTA
SGTB
SLC25A47
TXN
UBQLN1
UBQLN2
USP40
182 interacting genes:
ADAM21
ADIPOQ
ADRM1
AGR2
AGR3
AOC3
BAG6
BCL2L12
BTC
C1QA
C1QL4
C1QTNF1
C1QTNF5
C1QTNF6
C3orf52
C5orf46
CD79B
CD99
CD99L2
CDH15
CDSN
CHRNG
COL1A2
COL8A2
CREB3L3
CSF1
CST1
CTAG1A
CTAG1B
CTSL
CXCL8
CYB5R1
DEFA6
DEFB131A
DKK3
DMKN
EDA2R
EDAR
EFEMP1
EFEMP2
ERP27
ERP29
ETNK1
EVA1B
F11R
FERD3L
FGF21
FIP1L1
FKBP7
FSTL1
FXYD2
FXYD7
FZD7
GABARAPL2
GAL
GALP
GHR
GIP
GPX7
GRN
GUCA2A
GYPA
HSP90AA1
HSP90AB1
HSPA13
HSPA4
IER3
IGFBP6
IGL
IGLC1
IL6ST
IRF3
IRF5
ITPRIPL1
KASH5
KCNA1
KCNA10
KCNE5
KLHL20
KRT6A
KTN1
LAIR2
LAT
LCN2
LDLRAD4
LSMEM2
MRAP2
MS4A3
MSMB
MSTN
MYDGF
MYOC
NAXD
NME3
NPVF
NR3C1
NRSN2
NXF1
PAGE3
PBXIP1
PCDHA4
PCDHGA4
PFN2
PGLYRP2
PGR
PIAS1
PLAAT4
PMEPA1
PODXL
PPIB
PPIC
PPP1R3C
PRAP1
PRB4
PRRG2
PSORS1C2
PTN
PYY
RCN1
RNASE10
RNF144A
RNF144B
RNF170
RPN1
SDC4
SDF2L1
SERPINE1
SERPINI2
SGCA
SGTB
SHISA4
SHISA5
SLPI
SMAGP
SMIM14
SMIM5
SOD3
SPINK9
SPN
SPP1
SPPL2A
SRGN
SRL
STMP1
SUOX
SYT11
SYT4
TFF3
TFRC
TGFA
TIAM1
TMEM154
TMEM174
TMEM230
TMEM31
TMEM98
TMPO
TMPRSS11D
TMUB2
TNFRSF10C
TNFRSF13B
TNFRSF19
TNFRSF1A
TNFRSF21
TNFSF12
TRIM5
TWSG1
TXNDC12
UBL4A
UBQLN2
UPK3A
USP14
USP5
USP9X
VIP
WBP1L
WFDC12
WFDC13
WFDC5
ZBTB8B
ZG16
ZG16B
Entrez ID
712
6449
HPRD ID
00393
04568
Ensembl ID
ENSG00000173372
ENSG00000104969
Uniprot IDs
P02745
O43765
PDB IDs
1PK6
2JG8
2JG9
2WNU
2WNV
5HKJ
5HZF
6FCZ
6Z6V
9C9L
9C9U
2VYI
4CPG
4GOD
4GOE
4GOF
Enriched GO Terms of Interacting Partners
?
Complement Component C1q Complex Binding
Complement Activation, Classical Pathway
Complement Component C1 Complex
Complement Activation
Blood Microparticle
Cell Surface
Opsonization
Immune Effector Process
Positive Regulation Of ERAD Pathway
Symbiont Cell Surface
Defense Response To Symbiont
Defense Response To Other Organism
Regulation Of ERAD Pathway
Innate Immune Response
Regulation Of Protein Metabolic Process
Extracellular Region
Response To Stress
Humoral Immune Response
Virion Binding
Activation Of Immune Response
Extracellular Matrix
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Response To External Biotic Stimulus
Regulation Of Immune System Process
Immune System Process
Positive Regulation Of Immune Response
Defense Response
Response To Other Organism
Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
TRC Complex
Regulation Of Immune Response
Immune Response
Extracellular Space
Identical Protein Binding
Negative Regulation Of Endothelial Cell Migration
Complement Component C1q Complex
Positive Regulation Of Immune System Process
Protein Targeting To ER
Regulation Of Response To Endoplasmic Reticulum Stress
ERAD Pathway
Regulation Of Multicellular Organismal Development
Establishment Of Protein Localization To Endoplasmic Reticulum
IgM Binding
Positive Regulation Of Proteolysis
Negative Regulation Of Immune System Process
Polyubiquitin Modification-dependent Protein Binding
Acute-phase Response
Positive Regulation Of Proteasomal Protein Catabolic Process
Postsynapse
Extracellular Region
Extracellular Space
Protein Binding
Endoplasmic Reticulum Lumen
Response To Bacterium
Defense Response To Bacterium
Collagen Trimer
Response To Stress
Membrane
Response To Other Organism
Antimicrobial Humoral Response
Endoplasmic Reticulum
Immune System Process
Regulation Of Immune System Process
Humoral Immune Response
Peptidase Inhibitor Activity
Negative Regulation Of Cell Activation
Positive Regulation Of Leukocyte Migration
Serine-type Endopeptidase Inhibitor Activity
Defense Response
Extracellular Exosome
Defense Response To Symbiont
Negative Regulation Of Proteasomal Protein Catabolic Process
Antibacterial Humoral Response
Plasma Membrane
Immune Response
Defense Response To Other Organism
Negative Regulation Of Leukocyte Activation
Identical Protein Binding
Negative Regulation Of Cell Adhesion
Positive Regulation Of MAPK Cascade
Response To External Biotic Stimulus
Tumor Necrosis Factor Receptor Activity
Negative Regulation Of Proteolysis
Positive Regulation Of Intracellular Signal Transduction
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Positive Regulation Of Immune System Process
Hormone Activity
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Glucocorticoid Metabolic Process
Growth Factor Activity
Fibronectin Binding
Macrophage Apoptotic Process
BAT3 Complex
Regulation Of Cell Adhesion
Protein Folding
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Lymphocyte Proliferation
Epidermal Growth Factor Receptor Binding
Negative Regulation Of Mononuclear Cell Proliferation
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Tagcloud (Intersection)
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