C1QA

Name	complement C1q A chain
Structure
Novel Interactors	1 novel interactors: RHOA
Interactors	31 interactors: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HMGB1 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 SGTA SGTB SLC25A47 TXN UBQLN1 UBQLN2 USP40
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface
	Molecular Function	Amyloid-beta Binding Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding
	Biological Process	Microglial Cell Activation Immune System Process Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Neuron Remodeling Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning
Pathways	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs	Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab
Diseases	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS	Inflammatory biomarkers (multivariate analysis) ( 33110245 )
Entrez ID	712
HPRD ID	00393
Ensembl ID	ENSG00000173372
Uniprot IDs	P02745
PDB IDs	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
GO Terms Enriched among Interactors ?	Complement Component C1q Complex Binding Complement Activation, Classical Pathway Complement Component C1 Complex Complement Activation Blood Microparticle Cell Surface Opsonization Immune Effector Process Positive Regulation Of ERAD Pathway Symbiont Cell Surface Defense Response To Symbiont Defense Response To Other Organism Regulation Of ERAD Pathway Innate Immune Response Regulation Of Protein Metabolic Process Extracellular Region Response To Stress Humoral Immune Response Virion Binding Activation Of Immune Response Extracellular Matrix Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To External Biotic Stimulus Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Defense Response Response To Other Organism Negative Regulation By Host Of Viral Glycoprotein Metabolic Process TRC Complex Regulation Of Immune Response Immune Response Extracellular Space Identical Protein Binding Negative Regulation Of Endothelial Cell Migration Complement Component C1q Complex Positive Regulation Of Immune System Process Protein Targeting To ER Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Multicellular Organismal Development Establishment Of Protein Localization To Endoplasmic Reticulum IgM Binding Positive Regulation Of Proteolysis Negative Regulation Of Immune System Process Polyubiquitin Modification-dependent Protein Binding Acute-phase Response Positive Regulation Of Proteasomal Protein Catabolic Process Postsynapse